{"id":"https://openalex.org/W109210309","doi":null,"title":"Exploring motor neuron degeneration in ALS - prevention by glycoursodeoxycholic acid and signaling to microglia","display_name":"Exploring motor neuron degeneration in ALS - prevention by glycoursodeoxycholic acid and signaling to microglia","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W109210309","mag":"109210309"},"language":"de","primary_location":{"id":"pmh:oai:run.unl.pt:10362/12438","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/12438","pdf_url":"https://run.unl.pt/bitstreams/52ec0b57-e01e-449d-84c0-31ab62fd3093/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://run.unl.pt/bitstreams/52ec0b57-e01e-449d-84c0-31ab62fd3093/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019862373","display_name":"Joana Carolina Marinho Cunha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joana Carolina Marinho Cunha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019862373"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/motor-neuron-degeneration","display_name":"motor neuron degeneration","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glycoursodeoxycholic-acid","display_name":"glycoursodeoxycholic acid","score":0.9670000076293945},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.75},{"id":"https://openalex.org/keywords/sod1-g93a-mutation","display_name":"SOD1 G93A mutation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8360000252723694},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9629999995231628},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/microglial-phagocytosis","display_name":"microglial phagocytosis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8223814964294434},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6293448805809021},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.6047374606132507},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.5698035359382629},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.48997917771339417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32324323058128357},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26901739835739136},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.12654253840446472},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11640685796737671},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09172642230987549},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:run.unl.pt:10362/12438","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/12438","pdf_url":"https://run.unl.pt/bitstreams/52ec0b57-e01e-449d-84c0-31ab62fd3093/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:109210309","doi":null,"is_oa":false,"landing_page_url":"https://run.unl.pt/bitstream/10362/12438/1/Cunha_2012.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:run.unl.pt:10362/12438","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/12438","pdf_url":"https://run.unl.pt/bitstreams/52ec0b57-e01e-449d-84c0-31ab62fd3093/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4593245108","display_name":"SER\u00c1 A MICROGLIA UM NOVO ALVO FARMACOL\u00d3GICO COM POTENCIAL INTERESSE NA ESCLEROSE LATERAL AMIOTR\u00d3FICA (ELA)?","funder_award_id":"PTDC/SAU-FAR/118787/2010","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W109210309.pdf","grobid_xml":"https://content.openalex.org/works/W109210309.grobid-xml"},"referenced_works_count":213,"referenced_works":["https://openalex.org/W1482841897","https://openalex.org/W1512339474","https://openalex.org/W1514992074","https://openalex.org/W1530199299","https://openalex.org/W1545372895","https://openalex.org/W1552106782","https://openalex.org/W1571163061","https://openalex.org/W1685302421","https://openalex.org/W1898891273","https://openalex.org/W1947298690","https://openalex.org/W1967062507","https://openalex.org/W1967086577","https://openalex.org/W1971692139","https://openalex.org/W1974114814","https://openalex.org/W1976277934","https://openalex.org/W1977040584","https://openalex.org/W1977604451","https://openalex.org/W1978328220","https://openalex.org/W1978571886","https://openalex.org/W1978793403","https://openalex.org/W1979358478","https://openalex.org/W1980394496","https://openalex.org/W1981093402","https://openalex.org/W1981988940","https://openalex.org/W1984139957","https://openalex.org/W1984761110","https://openalex.org/W1984997174","https://openalex.org/W1986841892","https://openalex.org/W1987138690","https://openalex.org/W1988726352","https://openalex.org/W1988931872","https://openalex.org/W1989464571","https://openalex.org/W1989633016","https://openalex.org/W1991014773","https://openalex.org/W1991805788","https://openalex.org/W1992390260","https://openalex.org/W1992507257","https://openalex.org/W1994768568","https://openalex.org/W1995776351","https://openalex.org/W1996576454","https://openalex.org/W1996788873","https://openalex.org/W1996962549","https://openalex.org/W1997112145","https://openalex.org/W1997311117","https://openalex.org/W1998289889","https://openalex.org/W1998672948","https://openalex.org/W1999410619","https://openalex.org/W2000112012","https://openalex.org/W2000397914","https://openalex.org/W2002104055","https://openalex.org/W2002771508","https://openalex.org/W2002777840","https://openalex.org/W2003674452","https://openalex.org/W2004414770","https://openalex.org/W2004941342","https://openalex.org/W2007088989","https://openalex.org/W2010037905","https://openalex.org/W2010233410","https://openalex.org/W2010608772","https://openalex.org/W2011007124","https://openalex.org/W2012851706","https://openalex.org/W2012992792","https://openalex.org/W2013323313","https://openalex.org/W2014100516","https://openalex.org/W2014953425","https://openalex.org/W2015266340","https://openalex.org/W2016420746","https://openalex.org/W2017081112","https://openalex.org/W2017678299","https://openalex.org/W2017756051","https://openalex.org/W2017850724","https://openalex.org/W2019155443","https://openalex.org/W2020074935","https://openalex.org/W2020174051","https://openalex.org/W2021460711","https://openalex.org/W2022367303","https://openalex.org/W2022723847","https://openalex.org/W2022933182","https://openalex.org/W2024846866","https://openalex.org/W2025413109","https://openalex.org/W2025628979","https://openalex.org/W2026141598","https://openalex.org/W2028902268","https://openalex.org/W2031226474","https://openalex.org/W2032572133","https://openalex.org/W2033158384","https://openalex.org/W2033966441","https://openalex.org/W2037054844","https://openalex.org/W2038697027","https://openalex.org/W2038797418","https://openalex.org/W2039620761","https://openalex.org/W2040533389","https://openalex.org/W2040678584","https://openalex.org/W2041740325","https://openalex.org/W2043258904","https://openalex.org/W2043340127","https://openalex.org/W2043363924","https://openalex.org/W2044222280","https://openalex.org/W2046919544","https://openalex.org/W2047462308","https://openalex.org/W2047895583","https://openalex.org/W2049135473","https://openalex.org/W2050300724","https://openalex.org/W2052332287","https://openalex.org/W2053137713","https://openalex.org/W2053830427","https://openalex.org/W2053848550","https://openalex.org/W2055061396","https://openalex.org/W2057247682","https://openalex.org/W2057378071","https://openalex.org/W2058020888","https://openalex.org/W2058327129","https://openalex.org/W2058742494","https://openalex.org/W2059248106","https://openalex.org/W2059355164","https://openalex.org/W2061072369","https://openalex.org/W2061681761","https://openalex.org/W2062279793","https://openalex.org/W2063056677","https://openalex.org/W2063249182","https://openalex.org/W2063827358","https://openalex.org/W2064017800","https://openalex.org/W2064863416","https://openalex.org/W2066874059","https://openalex.org/W2067847915","https://openalex.org/W2068147651","https://openalex.org/W2068872768","https://openalex.org/W2069814345","https://openalex.org/W2070010667","https://openalex.org/W2071832924","https://openalex.org/W2072074272","https://openalex.org/W2072127908","https://openalex.org/W2074364583","https://openalex.org/W2074753416","https://openalex.org/W2076186429","https://openalex.org/W2076535829","https://openalex.org/W2076636473","https://openalex.org/W2078040811","https://openalex.org/W2078541372","https://openalex.org/W2079246504","https://openalex.org/W2079756902","https://openalex.org/W2081879241","https://openalex.org/W2084765115","https://openalex.org/W2085204538","https://openalex.org/W2085662515","https://openalex.org/W2086692195","https://openalex.org/W2087031741","https://openalex.org/W2087247709","https://openalex.org/W2091142824","https://openalex.org/W2091915417","https://openalex.org/W2094660330","https://openalex.org/W2095444837","https://openalex.org/W2096386031","https://openalex.org/W2099707218","https://openalex.org/W2099846110","https://openalex.org/W2101898118","https://openalex.org/W2101927164","https://openalex.org/W2103369019","https://openalex.org/W2107132663","https://openalex.org/W2107768418","https://openalex.org/W2109759840","https://openalex.org/W2110184140","https://openalex.org/W2110284480","https://openalex.org/W2110310280","https://openalex.org/W2110646502","https://openalex.org/W2112880160","https://openalex.org/W2113107925","https://openalex.org/W2116041320","https://openalex.org/W2117427878","https://openalex.org/W2117890656","https://openalex.org/W2121396070","https://openalex.org/W2122131544","https://openalex.org/W2122430360","https://openalex.org/W2122828560","https://openalex.org/W2123413118","https://openalex.org/W2123779560","https://openalex.org/W2123848058","https://openalex.org/W2124629702","https://openalex.org/W2124667416","https://openalex.org/W2125501179","https://openalex.org/W2126556819","https://openalex.org/W2128635872","https://openalex.org/W2128815118","https://openalex.org/W2130435783","https://openalex.org/W2131899505","https://openalex.org/W2132852509","https://openalex.org/W2135118981","https://openalex.org/W2135522980","https://openalex.org/W2137389383","https://openalex.org/W2144099695","https://openalex.org/W2144507462","https://openalex.org/W2145172575","https://openalex.org/W2145992691","https://openalex.org/W2146061835","https://openalex.org/W2146546145","https://openalex.org/W2147220169","https://openalex.org/W2148726772","https://openalex.org/W2148898943","https://openalex.org/W2149239016","https://openalex.org/W2149318226","https://openalex.org/W2151927746","https://openalex.org/W2154107855","https://openalex.org/W2159744102","https://openalex.org/W2160059242","https://openalex.org/W2161737261","https://openalex.org/W2161768939","https://openalex.org/W2165863447","https://openalex.org/W2166155593","https://openalex.org/W2166291746","https://openalex.org/W2167912995","https://openalex.org/W2171789386","https://openalex.org/W2323608496","https://openalex.org/W2417841328"],"related_works":["https://openalex.org/W98436654","https://openalex.org/W2267866885","https://openalex.org/W7098629980","https://openalex.org/W2966405595","https://openalex.org/W2895578831","https://openalex.org/W317123096","https://openalex.org/W7063895967","https://openalex.org/W3032351495","https://openalex.org/W7219244300","https://openalex.org/W3173975078"],"abstract_inverted_index":{"Amyotrophic":[0],"lateral":[1],"sclerosis":[2],"(ALS)":[3],"is":[4,24,35],"a":[5,59,69,199,216],"fatal":[6],"neurodegenerative":[7,105],"disease":[8],"that":[9],"affects":[10],"mainly":[11],"motor":[12,32,66],"neurons.":[13,33],"Neuronal":[14],"pathology":[15],"involves":[16],"glial":[17],"cells,":[18],"in":[19,46,101,125,147,155],"particular":[20],"microglia.":[21],"However":[22],"it":[23],"not":[25],"known":[26],"how":[27],"these":[28],"cells":[29,112,149,197],"interact":[30],"with":[31,114,144],"This":[34],"particularly":[36],"important":[37],"because":[38],"till":[39],"now":[40],"no":[41],"therapy":[42],"has":[43,97],"shown":[44,98],"efficacy":[45,90],"ALS":[47,201,220],"treatment.":[48],"Here,":[49],"we":[50,109,162],"aim":[51],"(i)":[52],"to":[53,74,80,87,157,172,211],"evaluate":[54],"the":[55,76,81,89,128,175],"suitability":[56],"of":[57,63,71,78,91,153,219],"NSC-34,":[58],"hybrid":[60],"cell":[61,131],"line":[62],"neuroblastoma":[64],"and":[65,85,104,127,141,168,187,209],"neurons,":[67],"as":[68,165,198,205,215],"model":[70],"ALS,":[72],"(ii)":[73],"explore":[75],"reactivity":[77],"microglia":[79,185,212],"neuronal":[82,181],"released":[83,180],"factors":[84,182],"(iii)":[86],"assess":[88],"glycoursodeoxycholic":[92],"acid":[93],"(GUDCA),":[94],"which":[95],"already":[96],"beneficial":[99,207],"effects":[100,208],"several":[102],"neurodevelopmental":[103],"diseases.":[106],"For":[107],"that,":[108],"used":[110],"NSC-34":[111],"transfected":[113],"human":[115],"superoxide":[116],"dismutase":[117],"1":[118],"(hSOD1),":[119],"either":[120],"wild":[121],"type":[122],"or":[123],"mutated":[124],"G93A":[126],"microglial":[129],"N9":[130,184],"line.":[132],"We":[133],"observed":[134],"mitochondrial":[135],"dysfunction,":[136],"energy":[137],"impairment,":[138],"NO":[139],"production":[140],"metalloproteinase-9":[142],"activation,":[143],"consequent":[145],"apoptosis":[146,186],"NSC-34/hSOD1G93A":[148,196],"after":[150],"4":[151],"days":[152],"differentiation,":[154],"comparison":[156],"NSC-34/hSOD1wt":[158],"cells.":[159],"In":[160],"addition,":[161],"established":[163],"GUDCA":[164,204],"an":[166],"anti-apoptotic":[167],"anti-inflammatory":[169],"agent,":[170],"able":[171],"prevent":[173],"all":[174],"above":[176],"mentioned":[177],"features.":[178],"Finally,":[179],"induced":[183],"decreased":[188],"their":[189],"phagocytic":[190],"ability.":[191],"Overall,":[192],"our":[193],"results":[194],"emphasize":[195],"good":[200],"model,":[202],"highlight":[203],"having":[206],"point":[210],"neuroprotective":[213],"failure":[214],"determinant":[217],"mechanism":[218],"pathogenesis.":[221]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
