{"id":"https://openalex.org/W1088632","doi":null,"title":"In vitro synergy of tigecycline against Burkholderia cepacia complex and other multi-resistant, nonfermentative, Gram negative bacteria from cystic fibrosis patients","display_name":"In vitro synergy of tigecycline against Burkholderia cepacia complex and other multi-resistant, nonfermentative, Gram negative bacteria from cystic fibrosis patients","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1088632","mag":"1088632"},"language":"en","primary_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:30626","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/30626","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/30626","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/30626","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038338023","display_name":"John Kenning","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John Kenning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038338023"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tigecycline","display_name":"tigecycline","score":1.0},{"id":"https://openalex.org/keywords/burkholderia-cepacia-complex","display_name":"Burkholderia cepacia complex","score":0.9950000047683716},{"id":"https://openalex.org/keywords/burkholderia-multivorans","display_name":"Burkholderia multivorans","score":0.984000027179718},{"id":"https://openalex.org/keywords/burkholderia-cenocepacia","display_name":"Burkholderia cenocepacia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stenotrophomonas-maltophilia","display_name":"Stenotrophomonas maltophilia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/achromobacter-xylosoxidans","display_name":"Achromobacter xylosoxidans","score":0.996999979019165},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/multidrug-resistant-gram-negative-bacteria","display_name":"multidrug-resistant Gram-negative bacteria","score":0.8619999885559082},{"id":"https://openalex.org/keywords/synergistic-antimicrobial-activity","display_name":"antimicrobial synergy","score":0.871999979019165},{"id":"https://openalex.org/keywords/minocycline","display_name":"minocycline","score":0.8320000171661377},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.7680000066757202},{"id":"https://openalex.org/keywords/non-fermenting-gram-negative-bacilli","display_name":"non-fermenting Gram-negative bacilli","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C2777027569","wikidata":"https://www.wikidata.org/wiki/Q420595","display_name":"Tigecycline","level":3,"score":0.9748433232307434},{"id":"https://openalex.org/C2777979451","wikidata":"https://www.wikidata.org/wiki/Q4810500","display_name":"Burkholderia cenocepacia","level":4,"score":0.875754714012146},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.788760244846344},{"id":"https://openalex.org/C2780855054","wikidata":"https://www.wikidata.org/wiki/Q135239","display_name":"Burkholderia","level":3,"score":0.7100062370300293},{"id":"https://openalex.org/C2777756538","wikidata":"https://www.wikidata.org/wiki/Q21401468","display_name":"Burkholderia cepacia complex","level":4,"score":0.6094526648521423},{"id":"https://openalex.org/C2776352461","wikidata":"https://www.wikidata.org/wiki/Q142705","display_name":"Stenotrophomonas maltophilia","level":4,"score":0.6063578128814697},{"id":"https://openalex.org/C2776870249","wikidata":"https://www.wikidata.org/wiki/Q149128","display_name":"Bacilli","level":3,"score":0.5485825538635254},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.5479738712310791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.537812352180481},{"id":"https://openalex.org/C2778275353","wikidata":"https://www.wikidata.org/wiki/Q415336","display_name":"Minocycline","level":3,"score":0.5264304876327515},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5048680901527405},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.44525817036628723},{"id":"https://openalex.org/C2777287306","wikidata":"https://www.wikidata.org/wiki/Q2707476","display_name":"Stenotrophomonas","level":4,"score":0.4416337311267853},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.33536338806152344},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2360631227493286},{"id":"https://openalex.org/C2781463711","wikidata":"https://www.wikidata.org/wiki/Q131143","display_name":"Pseudomonas","level":3,"score":0.15709024667739868},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:uilis.unsyiah.ac.id:30626","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/30626","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/30626","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/996622","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/996622","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:1088632","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:30626","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/30626","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/30626","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1088632.pdf","grobid_xml":"https://content.openalex.org/works/W1088632.grobid-xml"},"referenced_works_count":139,"referenced_works":["https://openalex.org/W74856719","https://openalex.org/W88723141","https://openalex.org/W321794343","https://openalex.org/W646067358","https://openalex.org/W1482476186","https://openalex.org/W1483646930","https://openalex.org/W1553141390","https://openalex.org/W1869062106","https://openalex.org/W1932040433","https://openalex.org/W1955222196","https://openalex.org/W1955612312","https://openalex.org/W1964593670","https://openalex.org/W1966949405","https://openalex.org/W1968014038","https://openalex.org/W1968167870","https://openalex.org/W1970082145","https://openalex.org/W1974522161","https://openalex.org/W1977633114","https://openalex.org/W1978226795","https://openalex.org/W1983723791","https://openalex.org/W1983789991","https://openalex.org/W1984503995","https://openalex.org/W1986131458","https://openalex.org/W1986326641","https://openalex.org/W1987135462","https://openalex.org/W1989349116","https://openalex.org/W1993867929","https://openalex.org/W1995343697","https://openalex.org/W1999101262","https://openalex.org/W1999156712","https://openalex.org/W2006894520","https://openalex.org/W2008798861","https://openalex.org/W2009671723","https://openalex.org/W2010217164","https://openalex.org/W2010844072","https://openalex.org/W2014356810","https://openalex.org/W2021092246","https://openalex.org/W2022634662","https://openalex.org/W2022840839","https://openalex.org/W2022941489","https://openalex.org/W2028164857","https://openalex.org/W2029672119","https://openalex.org/W2031005159","https://openalex.org/W2034152882","https://openalex.org/W2045286729","https://openalex.org/W2045873707","https://openalex.org/W2048045671","https://openalex.org/W2048924258","https://openalex.org/W2049587945","https://openalex.org/W2050424409","https://openalex.org/W2054028122","https://openalex.org/W2057843953","https://openalex.org/W2067757858","https://openalex.org/W2068781163","https://openalex.org/W2072957254","https://openalex.org/W2082389567","https://openalex.org/W2082781920","https://openalex.org/W2093861722","https://openalex.org/W2096002246","https://openalex.org/W2096641887","https://openalex.org/W2096779618","https://openalex.org/W2097098774","https://openalex.org/W2097236051","https://openalex.org/W2098935712","https://openalex.org/W2100619015","https://openalex.org/W2102144745","https://openalex.org/W2103176803","https://openalex.org/W2103193749","https://openalex.org/W2103884572","https://openalex.org/W2104048715","https://openalex.org/W2104654234","https://openalex.org/W2106470680","https://openalex.org/W2106673689","https://openalex.org/W2106916051","https://openalex.org/W2106952837","https://openalex.org/W2107347870","https://openalex.org/W2108016865","https://openalex.org/W2109638827","https://openalex.org/W2110219060","https://openalex.org/W2110249406","https://openalex.org/W2111712277","https://openalex.org/W2111914946","https://openalex.org/W2115886814","https://openalex.org/W2116817824","https://openalex.org/W2117992352","https://openalex.org/W2119142507","https://openalex.org/W2119514123","https://openalex.org/W2121890764","https://openalex.org/W2122229497","https://openalex.org/W2123686675","https://openalex.org/W2123796047","https://openalex.org/W2125737690","https://openalex.org/W2126192952","https://openalex.org/W2126610596","https://openalex.org/W2128476735","https://openalex.org/W2129148967","https://openalex.org/W2129149214","https://openalex.org/W2130805489","https://openalex.org/W2132787897","https://openalex.org/W2137949505","https://openalex.org/W2138609440","https://openalex.org/W2138763823","https://openalex.org/W2139186193","https://openalex.org/W2141963202","https://openalex.org/W2143530682","https://openalex.org/W2143584019","https://openalex.org/W2146125284","https://openalex.org/W2146749909","https://openalex.org/W2146799440","https://openalex.org/W2147497898","https://openalex.org/W2147640303","https://openalex.org/W2149341297","https://openalex.org/W2149687177","https://openalex.org/W2150232178","https://openalex.org/W2151906718","https://openalex.org/W2153258657","https://openalex.org/W2153822440","https://openalex.org/W2155069031","https://openalex.org/W2155246554","https://openalex.org/W2155737151","https://openalex.org/W2156288458","https://openalex.org/W2157515985","https://openalex.org/W2159005358","https://openalex.org/W2161523238","https://openalex.org/W2163771433","https://openalex.org/W2165268944","https://openalex.org/W2166716399","https://openalex.org/W2167671671","https://openalex.org/W2168465173","https://openalex.org/W2169140164","https://openalex.org/W2169405011","https://openalex.org/W2169545551","https://openalex.org/W2170206890","https://openalex.org/W2171326155","https://openalex.org/W2313952066","https://openalex.org/W2335663066","https://openalex.org/W2415450197","https://openalex.org/W2889200856","https://openalex.org/W3106798016"],"related_works":["https://openalex.org/W7043859244","https://openalex.org/W2083715131","https://openalex.org/W2153340558","https://openalex.org/W2897201777","https://openalex.org/W2425481925","https://openalex.org/W2082389567","https://openalex.org/W2731847799","https://openalex.org/W7154492777","https://openalex.org/W2809153467","https://openalex.org/W2184265554"],"abstract_inverted_index":{"Options":[0],"for":[1,87,236],"treating":[2],"Burkholderia":[3,51,54,61],"cepacia":[4],"complex":[5],"(Bcc)":[6],"and":[7,29,69,83,97,133,158,163,178,191,196,225,232,245,257],"other":[8,31,57,71,85,101,141,207],"multi-resistant":[9],"Gram":[10,47,74],"negative":[11,48,75],"bacilli":[12,49],"isolated":[13],"from":[14],"people":[15],"with":[16,155,176,194,206],"cystic":[17],"fibrosis":[18],"(CF)":[19],"are":[20,251,267],"limited.":[21],"We":[22],"assessed":[23],"the":[24,60,117,137,153,214,223,233,240],"in-vitro":[25,147,215],"activity":[26,148,172,187,216],"of":[27,37,45,59,81,99,113,131,139,152,160,180,198,217,229,254],"tigecycline":[28,82,96,218],"eleven":[30,84],"antimicrobial":[32],"agents":[33,208],"against":[34,173,188],"a":[35,129,252],"collection":[36,41],"these":[38,174],"organisms.":[39],"The":[40,110],"comprised":[42],"128":[43],"isolates":[44,181,199],"CF-associated":[46,73],"(31":[50],"multivorans,":[52],"16":[53],"cenocepacia,":[55],"4":[56],"members":[58,151],"species,":[62,175],"47":[63],"Stenotrophomonas":[64],"maltophilia,":[65],"20":[66],"Achromobacter":[67],"xylosoxidans,":[68],"10":[70],"miscellaneous":[72],"bacilli).":[76],"Minimum":[77],"inhibitory":[78],"concentrations":[79],"(MIC)":[80],"antimicrobials":[86,102],"each":[88,98],"isolate":[89],"were":[90],"determined":[91,104],"using":[92,105],"E-test.":[93],"Synergy":[94],"between":[95,242],"eight":[100],"was":[103],"an":[106],"E-test":[107],"overlay":[108],"method.":[109],"epidemiological":[111],"spread":[112],"organisms":[114],"indicated":[115],"that":[116,259],"Leeds":[118],"Teaching":[119],"Hospitals":[120],"NHS":[121],"Trust":[122],"(LTHT)":[123],"infection":[124],"control":[125],"policies":[126],"have":[127],"had":[128],"measure":[130],"success":[132,247],"our":[134],"work":[135],"followed":[136],"pattern":[138],"many":[140],"CF":[142],"units.":[143],"Tigecycline":[144,184,203],"showed":[145,170,185],"poor":[146],"versus":[149],"all":[150],"Bcc,":[154],"only":[156],"13%":[157],"3%":[159],"B.":[161,164],"cenocepacia":[162],"multivorans":[165],"susceptible,":[166,201],"respectively.":[167,202],"Conversely":[168],"minocycline":[169],"good":[171,186],"94%":[177],"91%":[179],"being":[182,200],"susceptible.":[183],"A.":[189],"xyloxidans":[190],"S.":[192],"maltophilia":[193],"85%":[195],"77%":[197],"in":[204,211],"combination":[205],"mostly":[209],"resulted":[210],"indifference.":[212],"Although":[213],"is":[219],"variable,":[220],"we":[221],"reviewed":[222],"potential":[224],"future":[226],"clinical":[227,246],"impact":[228],"this":[230,262],"study":[231],"likely":[234],"issues":[235],"further":[237,265],"study.":[238],"Whilst":[239],"relationship":[241],"synergy/MIC":[243],"testing":[244],"remains":[248],"unclear,":[249],"there":[250],"number":[253],"promising":[255],"developments":[256],"ideas":[258],"may":[260],"clarify":[261],"situation":[263],"\u2013":[264],"studies":[266],"warranted.":[268]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}