{"id":"https://openalex.org/W108600652","doi":null,"title":"Neuroinflammation in Multiple System Atrophy is Influenced by Pathological Alpha-synuclein Aggregates","display_name":"Neuroinflammation in Multiple System Atrophy is Influenced by Pathological Alpha-synuclein Aggregates","publication_year":2014,"publication_date":"2014-11-10","ids":{"openalex":"https://openalex.org/W108600652","mag":"108600652"},"language":"en","primary_location":{"id":"pmh:oai:research-repository.griffith.edu.au:10072/64498","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10072/64498","pdf_url":"http://hdl.handle.net/10072/64498","source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference output"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10072/64498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007307080","display_name":"Rowan A. W. Radford","orcid":"https://orcid.org/0000-0002-7906-6795","observed_orcids":["https://orcid.org/0000-0002-7906-6795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rowan A. W. Radford","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7906-6795","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089732655","display_name":"Alexandre Nay Rcom-H'cheo-Gauthier","orcid":"https://orcid.org/0000-0003-0835-5992","observed_orcids":["https://orcid.org/0000-0003-0835-5992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandre Nay Rcom-H'cheo-Gauthier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Matthew J. Wong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew J. Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103571309","display_name":"Emma D. Eaton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma D. Eaton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113469500","display_name":"M. Quilty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Quilty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030829136","display_name":"Adrian Cuda Banda Meedeniya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrian Cuda Banda Meedeniya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028848778","display_name":"James Clement Vickers","orcid":"https://orcid.org/0000-0001-5671-4879","observed_orcids":["https://orcid.org/0000-0001-5671-4879"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James C. Vickers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5671-4879","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012969008","display_name":"Wei Gai","orcid":"https://orcid.org/0000-0002-6005-1059","observed_orcids":["https://orcid.org/0000-0002-6005-1059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Gai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6005-1059","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075562396","display_name":"Gilles J. Guillemin","orcid":"https://orcid.org/0000-0001-8105-4470","observed_orcids":["https://orcid.org/0000-0001-8105-4470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilles J. Guillemin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8105-4470","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043168275","display_name":"Anwar Norazit","orcid":"https://orcid.org/0000-0003-2724-7591","observed_orcids":["https://orcid.org/0000-0003-2724-7591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anwar Norazit","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2724-7591","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111968402","display_name":"AK West","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AK West","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090647382","display_name":"Tracey C. Dickson","orcid":"https://orcid.org/0000-0002-9196-1661","observed_orcids":["https://orcid.org/0000-0002-9196-1661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tracey C. Dickson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9196-1661","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017039332","display_name":"Roger S. Chung","orcid":"https://orcid.org/0000-0002-9286-947X","observed_orcids":["https://orcid.org/0000-0002-9286-947X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger S. Chung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010893750","display_name":"Dean L. Pountney","orcid":"https://orcid.org/0000-0002-0653-7832","observed_orcids":["https://orcid.org/0000-0002-0653-7832"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dean L. Pountney","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0653-7832","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01244813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.972000002861023},{"id":"https://openalex.org/keywords/glial-cytoplasmic-inclusions","display_name":"glial cytoplasmic inclusions","score":0.9850000143051147},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.9470000267028809},{"id":"https://openalex.org/keywords/astrocyte-morphology","display_name":"astrocyte morphology","score":0.8740000128746033},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8230000138282776},{"id":"https://openalex.org/keywords/medial-forebrain-bundle","display_name":"medial forebrain bundle","score":0.6919999718666077},{"id":"https://openalex.org/keywords/extracellular-alpha-synuclein","display_name":"extracellular alpha-synuclein","score":0.75},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.8325260877609253},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7642921805381775},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5924715995788574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5691203474998474},{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.5664802193641663},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.556991696357727},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5124940872192383},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4849965274333954},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.43012282252311707},{"id":"https://openalex.org/C2908656565","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrocytosis","level":3,"score":0.41535037755966187},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.41487014293670654},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2756296694278717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20579096674919128},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.13306552171707153},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09097996354103088}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:research-repository.griffith.edu.au:10072/64498","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10072/64498","pdf_url":"http://hdl.handle.net/10072/64498","source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference output"},{"id":"mag:108600652","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.griffith.edu.au/handle/10072/64498","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:research-repository.griffith.edu.au:10072/64498","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10072/64498","pdf_url":"http://hdl.handle.net/10072/64498","source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference output"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W108600652.pdf","grobid_xml":"https://content.openalex.org/works/W108600652.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2153259779","https://openalex.org/W2518374770","https://openalex.org/W2174469825","https://openalex.org/W2901746027","https://openalex.org/W7099950090","https://openalex.org/W7037524986","https://openalex.org/W6889808855","https://openalex.org/W77872309","https://openalex.org/W4224937242","https://openalex.org/W2360825148"],"abstract_inverted_index":{"Introduction:":[0],"Multiple":[1],"system":[2],"atrophy":[3],"(MSA)":[4],"closely":[5],"resembles":[6],"Parkinson\u2019s":[7],"disease":[8],"(PD)":[9],"clinically,":[10],"but":[11,221],"with":[12,112,141],"a":[13,142,196],"range":[14],"of":[15,33,77,172,204,234],"autonomic":[16],"signs.":[17],"However,":[18],"unlike":[19],"PD":[20],"that":[21,230],"displays":[22],"primarily":[23],"neuronal":[24],"pathology,":[25],"MSA":[26,60,81,205,242],"exhibits":[27],"widespread":[28,216],"astrogliosis":[29],"and":[30,50,62,65,82,91,97,99,114,131,153,175,240],"the":[31,45,93,157,209,219],"occurrence":[32],"\u03b1-synuclein":[34],"(\u03b1-syn)":[35],"glial":[36],"cytoplasmic":[37],"inclusions":[38,49,178],"(GCIs)":[39],"in":[40,52,80,107,179,189,195,215,218],"mature":[41,180],"oligodendrocytes.":[42,183],"To":[43],"investigate":[44],"relationship":[46],"between":[47,149],"\u03b1-syn":[48,167,177,193,207,235],"neuroinflammation":[51,217],"MSA,":[53],"we":[54,72],"conducted":[55],"quantitative":[56],"morphometric":[57],"analysis":[58],"on":[59],"cases,":[61],"cell":[63,164],"culture":[64,165],"animal":[66],"model":[67],"studies.Methods:":[68],"Using":[69],"Imaris":[70],"software,":[71],"obtained":[73],"\u201cskinned\u201d":[74],"three-dimensional":[75],"models":[76],"GFAP-positive":[78],"astrocytes":[79,136,174,185],"normal":[83],"tissue":[84],"(n":[85],"=":[86],"75)":[87],"from":[88],"confocal":[89],"z-stacks":[90],"measured":[92],"astrocyte":[94,110,239],"process":[95,151],"length":[96,152],"thickness":[98],"radial":[100,154],"distance":[101,155],"to":[102,119,156,192],"GCI.Results:":[103],"Astrocyte":[104],"activation":[105,171],"results":[106],"highly":[108],"ramified":[109],"morphology":[111],"extended":[113],"thickened":[115],"processes.":[116],"Astrocytes":[117],"proximal":[118],"GCI-containing":[120],"oligodendrocytes":[121],"(r":[122,137],"<":[123],"25":[124,139],"\u00b5m)":[125],"had":[126],"significantly":[127],"(p,":[128],"0.05)":[129],"longer":[130],"thicker":[132],"processes":[133],"than":[134],"distal":[135],">":[138],"\u00b5m),":[140],"reciprocal":[143],"linear":[144],"correlation":[145],"(m,":[146],"90":[147],"\u00b5m2)":[148],"mean":[150],"nearest":[158],"GCI":[159],"(R2,":[160],"0.7).":[161],"In":[162],"primary":[163],"studies,":[166],"addition":[168],"caused":[169],"ERK-dependent":[170],"rat":[173,182],"perinuclear":[176],"(MOSP-positive)":[181],"Activated":[184],"were":[186],"also":[187],"observed":[188],"close":[190],"proximity":[191],"deposits":[194],"unilateral":[197,202],"rotenone-lesion":[198],"mouse":[199,210],"model.":[200],"Moreover,":[201],"injection":[203],"tissue-derived":[206],"into":[208],"medial":[211],"forebrain":[212],"bundle":[213],"resulted":[214],"\u03b1-syn-injected,":[220],"not":[222],"sham-injected":[223],"hemisphere.Conclusion:":[224],"Taken":[225],"together,":[226],"our":[227],"data":[228],"suggests":[229],"localized":[231],"extracellular":[232],"concentrations":[233],"may":[236],"underlie":[237],"both":[238],"oligodendrocyte":[241],"pathological":[243],"features.":[244]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
