{"id":"https://openalex.org/W108514548","doi":null,"title":"Longitudinal assessment of heart function of ZSF1 rats by echocardiography","display_name":"Longitudinal assessment of heart function of ZSF1 rats by echocardiography","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W108514548","mag":"108514548"},"language":"fr","primary_location":{"id":"pmh:oai:HAL:hal-01272754v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01272754","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental and Applied Animal Sciences, 2013, 1 (1), pp.125--139","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047013805","display_name":"William Riboulet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"William Riboulet","raw_affiliation_strings":["F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011141433","display_name":"Emmanuelle Hainaut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emmanuelle Hainaut","raw_affiliation_strings":["F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042803406","display_name":"Philippe Verry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philippe Verry","raw_affiliation_strings":["F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069505910","display_name":"Julie Lambotte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Julie Lambotte","raw_affiliation_strings":["F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083315704","display_name":"B.A. Jacobsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"B.A. Jacobsen","raw_affiliation_strings":["F.Hoffmann-La-Roche (Basel, Switzerland), Non-Clinical Safety group;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F.Hoffmann-La-Roche (Basel, Switzerland), Non-Clinical Safety group;","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043370976","display_name":"Isabelle Lartaud","orcid":"https://orcid.org/0000-0001-9257-6311","observed_orcids":["https://orcid.org/0000-0001-9257-6311"]},"institutions":[{"id":"https://openalex.org/I4387156376","display_name":"Cibles th\u00e9rapeutiques, formulation et expertise pr\u00e9clinique du m\u00e9dicament","ror":"https://ror.org/05adajg67","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4387156376","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Lartaud","raw_affiliation_strings":["Universit\u00e9 de Lorraine, EA3452 CITHEFOR (Nancy, France), Drug targets, formulation and preclinical assessment"],"raw_orcid":"https://orcid.org/0000-0001-9257-6311","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, EA3452 CITHEFOR (Nancy, France), Drug targets, formulation and preclinical assessment","institution_ids":["https://openalex.org/I4387156376","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024707341","display_name":"Agnes M. Benardeau","orcid":"https://orcid.org/0000-0002-7075-6263","observed_orcids":["https://orcid.org/0000-0002-7075-6263"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Agn\u00e8s B\u00e9nardeau","raw_affiliation_strings":["F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division"],"raw_orcid":"https://orcid.org/0000-0002-7075-6263","affiliations":[{"raw_affiliation_string":"F.Hoffmann-La Roche (Basel, Switzerland), pRED Cardiovascular and Metabolism division","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037285842","display_name":"Karin Conde\u2010Knape","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140598","display_name":"Johnson & Johnson (United Kingdom)","ror":"https://ror.org/03qwpn290","country_code":"GB","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4210140598"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karin Conde-Knape","raw_affiliation_strings":["Johnson and Johnson Medical (London, UK), Cardiovascular and Metabolism division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson and Johnson Medical (London, UK), Cardiovascular and Metabolism division","institution_ids":["https://openalex.org/I4210140598"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2181,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59158158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"1","issue":"1","first_page":"125","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zsf1-rats","display_name":"ZSF1 rats","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.6819999814033508},{"id":"https://openalex.org/keywords/echocardiography","display_name":"echocardiography","score":0.8790000081062317},{"id":"https://openalex.org/keywords/longitudinal-assessment","display_name":"longitudinal assessment","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.4830000102519989},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C23036609","wikidata":"https://www.wikidata.org/wiki/Q7136027","display_name":"Parasternal line","level":2,"score":0.8628526329994202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7788828015327454},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7343186736106873},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6863823533058167},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6853013038635254},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5331883430480957},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.5250881910324097},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4806350767612457},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.4551926851272583},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.38639822602272034},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3562049865722656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32108503580093384}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:HAL:hal-01272754v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01272754","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental and Applied Animal Sciences, 2013, 1 (1), pp.125--139","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:108514548","doi":null,"is_oa":false,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-01272754","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W69551504","https://openalex.org/W1561443084","https://openalex.org/W1837827574","https://openalex.org/W1987944434","https://openalex.org/W2019514289","https://openalex.org/W2023606650","https://openalex.org/W2024385957","https://openalex.org/W2027378077","https://openalex.org/W2030328885","https://openalex.org/W2038613364","https://openalex.org/W2063071175","https://openalex.org/W2077708145","https://openalex.org/W2080010624","https://openalex.org/W2092100861","https://openalex.org/W2092644531","https://openalex.org/W2097674872","https://openalex.org/W2103209368","https://openalex.org/W2121395579","https://openalex.org/W2123055432","https://openalex.org/W2128099976","https://openalex.org/W2129347273","https://openalex.org/W2132825764","https://openalex.org/W2136952813","https://openalex.org/W2137199359","https://openalex.org/W2148303421","https://openalex.org/W2149926390","https://openalex.org/W2153454097","https://openalex.org/W2324030005","https://openalex.org/W2460081148","https://openalex.org/W2975364463"],"related_works":["https://openalex.org/W2978728608","https://openalex.org/W2050027556","https://openalex.org/W2101324161","https://openalex.org/W2802760591","https://openalex.org/W63883919","https://openalex.org/W4403818748","https://openalex.org/W2249714948","https://openalex.org/W2048157068","https://openalex.org/W2292473313","https://openalex.org/W2068578734"],"abstract_inverted_index":{"Development":[0],"of":[1,19,44,56,169,214,233,243],"Type":[2],"2":[3],"Diabetes":[4],"(T2D)":[5],"is":[6],"associated":[7],"with":[8],"cardiac":[9,108,211,236],"comorbidities":[10],"linked":[11],"to":[12,23,60,81,114,146,191,222],"micro-":[13],"and":[14,79,86,91,112,124,161,173,175,201,216,219],"macro-vasculature":[15],"defects.":[16],"The":[17],"aim":[18],"this":[20],"work":[21],"was":[22,104,144,179],"evaluate":[24],"age-dependent":[25],"changes":[26],"in":[27,32,58,74,96,240],"heart":[28,38,202],"function":[29,237],"by":[30,72,106,110,116,152,181,238],"echocardiography":[31,73,239],"ZSF1":[33,48,64,123,125,130,156,194,208,224],"rats":[34,49,126,131,157,165,195,209,225],"(Zucker":[35],"fatty/Spontaneously":[36],"hypertensive":[37],"failure":[39],"F1":[40],"hybrid),":[41],"a":[42,227],"model":[43,229],"metabolic":[45,244],"syndrome.":[46,245],"Male":[47],"were":[50,70,94,132,188],"studied":[51],"at":[52,138,148,154,183],"12-18-24-45-57":[53],"weeks":[54],"(W)":[55],"age":[57,168],"comparison":[59],"age-matched":[61],"male":[62],"lean":[63,122,147,164],"rats.":[65],"Left":[66],"ventricular":[67,142],"(LV)":[68],"dimensions":[69],"measured":[71,95],"parasternal":[75,97],"short":[76],"axis":[77],"view":[78,99],"M-mode":[80],"calculate":[82],"Ejection":[83],"Fraction":[84],"(EF)":[85],"Fractional":[87],"Shortening":[88],"(FS).":[89],"E":[90],"A":[92],"waves":[93],"four-chamber":[98],"(B-mode).":[100],"Blood":[101],"pressure":[102],"(BP)":[103],"monitored":[105],"tail-cuff,":[107],"structures":[109],"histology":[111],"sensitivity":[113],"ischemia":[115],"Langendorff":[117],"method.":[118],"At":[119],"all":[120],"ages,":[121],"displayed":[127],"moderate":[128],"hypertension.":[129],"heavier":[133],"(+47.4%":[134],"body":[135],"weight":[136],"(BW)":[137],"45W);":[139],"their":[140,186],"left":[141],"mass":[143],"similar":[145],"12W":[149],"but":[150],"increased":[151,220],"+46.4%":[153],"45W.":[155,184],"had":[158],"lower":[159],"EF":[160],"FS":[162],"than":[163],"from":[166],"the":[167,241],"24W":[170],"(respectively":[171],"-5%":[172],"-10%),":[174],"E/A":[176],"wave":[177],"ratio":[178],"lowered":[180],"24%":[182],"Moreover,":[185],"hearts":[187],"more":[189],"sensitive":[190],"ischemia.":[192,223],"Additionally":[193],"exhibited":[196],"deterioration":[197,213],"mainly":[198],"on":[199,235],"kidney":[200],"structure":[203],"along":[204],"aging.":[205],"With":[206],"age,":[207],"exhibit":[210],"hypertrophy,":[212],"diastolic":[215],"systolic":[217],"functions,":[218],"sensivity":[221],"are":[226],"promising":[228],"for":[230],"evaluating":[231],"effects":[232],"drugs":[234],"context":[242]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}