{"id":"https://openalex.org/W108456747","doi":null,"title":"From mild cognitive impairment to Alzheimer's disease - influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up.","display_name":"From mild cognitive impairment to Alzheimer's disease - influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up.","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W108456747","mag":"108456747","pmid":"https://pubmed.ncbi.nlm.nih.gov/19742390"},"language":"en","primary_location":{"id":"pmid:19742390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19742390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia i neurochirurgia polska","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059374033","display_name":"Joanna S. Siuda","orcid":"https://orcid.org/0000-0002-0340-660X","observed_orcids":["https://orcid.org/0000-0002-0340-660X"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Siuda","raw_affiliation_strings":["Katedra i Klinika Neurologii, SP Centralny Szpital Kliniczny SUM im. prof. K. Gibi\u0144skiego, ul.Medyk\u00f3w 14, 40-752 Katowice. siuda_j@poczta.onet.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Katedra i Klinika Neurologii, SP Centralny Szpital Kliniczny SUM im. prof. K. Gibi\u0144skiego, ul.Medyk\u00f3w 14, 40-752 Katowice. siuda_j@poczta.onet.pl","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035313480","display_name":"Agnieszka Gorzkowska","orcid":"https://orcid.org/0000-0001-5081-8343","observed_orcids":["https://orcid.org/0000-0001-5081-8343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnieszka Gorzkowska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068588668","display_name":"Maja Patalong\u2010Ogiewa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maja Patalong-Ogiewa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007788836","display_name":"Ewa Krzystanek","orcid":"https://orcid.org/0000-0003-4441-3088","observed_orcids":["https://orcid.org/0000-0003-4441-3088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewa Krzystanek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077869303","display_name":"Ewa Katarzyna Czech","orcid":"https://orcid.org/0000-0001-5421-4053","observed_orcids":["https://orcid.org/0000-0001-5421-4053"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewa Czech","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042763652","display_name":"Barbara E Wiechu\u0142a","orcid":"https://orcid.org/0000-0003-2859-3138","observed_orcids":["https://orcid.org/0000-0003-2859-3138"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Wiechu\u0142a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023935879","display_name":"Wojciech Garczorz","orcid":"https://orcid.org/0000-0002-5343-1205","observed_orcids":["https://orcid.org/0000-0002-5343-1205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wojciech Garczorz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089058489","display_name":"Alojzy Danch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alojzy Danch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016429635","display_name":"Barbara Jasi\u0144ska\u2010Myga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Jasi\u0144ska-Myga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109858833","display_name":"Grzegorz Opala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grzegorz Opala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5946,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.81329599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"4","first_page":"321","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dementia-progression","display_name":"dementia progression","score":0.8740000128746033},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.9049999713897705},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vascular-risk-factors","display_name":"vascular risk factors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mthfr-polymorphisms","display_name":"MTHFR polymorphisms","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.875166654586792},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.743962824344635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6029208302497864},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.5657132863998413},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.534921407699585},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.5340978503227234},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.475339412689209},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42750734090805054},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.41878488659858704},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4170273244380951},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.37012821435928345},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3524385690689087},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011044","descriptor_name":"Poland","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014806","descriptor_name":"Vitamin B 12 Deficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020138","descriptor_name":"Hyperhomocysteinemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19742390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19742390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia i neurochirurgia polska","raw_type":"Journal Article"},{"id":"mag:108456747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19742390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W135422390","https://openalex.org/W142575532","https://openalex.org/W1523783122","https://openalex.org/W1601475451","https://openalex.org/W1954961492","https://openalex.org/W1970201456","https://openalex.org/W1982215232","https://openalex.org/W1985850018","https://openalex.org/W1988318122","https://openalex.org/W1990561240","https://openalex.org/W1999530134","https://openalex.org/W2010307509","https://openalex.org/W2028289093","https://openalex.org/W2040048921","https://openalex.org/W2055566595","https://openalex.org/W2066349930","https://openalex.org/W2072691846","https://openalex.org/W2077781059","https://openalex.org/W2090268945","https://openalex.org/W2098300695","https://openalex.org/W2099614709","https://openalex.org/W2104020340","https://openalex.org/W2113478294","https://openalex.org/W2116950438","https://openalex.org/W2117673398","https://openalex.org/W2125256631","https://openalex.org/W2131045843","https://openalex.org/W2149614271","https://openalex.org/W2153415741","https://openalex.org/W2153631628","https://openalex.org/W2154170073","https://openalex.org/W2156220037","https://openalex.org/W2159122349","https://openalex.org/W2167487379"],"related_works":["https://openalex.org/W2116950438","https://openalex.org/W2092346376","https://openalex.org/W2154845450","https://openalex.org/W1968476606","https://openalex.org/W2167811769","https://openalex.org/W2100924464","https://openalex.org/W1211423668","https://openalex.org/W2056140370","https://openalex.org/W7096392820","https://openalex.org/W4297263076"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,78],"PURPOSE:":[2],"People":[3],"with":[4,133,221],"mild":[5],"cognitive":[6,105,222],"impairment":[7,106,223],"(MCI)":[8],"have":[9,198,227],"higher":[10],"risk":[11,21,40,63,122,140,154,217],"of":[12,49,58,212],"developing":[13],"dementia":[14,24,68,204,234],"than":[15],"the":[16,44,56,162,206,236],"general":[17],"population.":[18],"Currently":[19],"known":[20],"factors":[22,41,64,123,141,155,195,218],"for":[23,97],"include":[25],"older":[26],"age,":[27,98],"low":[28],"education":[29,101],"level,":[30],"gait":[31],"disorders,":[32],"hippocampal":[33],"atrophy,":[34],"and":[35,61,85,88,93,100,136,145,178,191],"apolipoprotein":[36],"E":[37],"allele.":[38],"Vascular":[39,153,216],"may":[42,197],"modify":[43],"neurodegenerative":[45],"process.":[46],"The":[47],"aim":[48],"this":[50],"study":[51],"was":[52,107,118],"therefore":[53],"to":[54,67,110,203,233],"assess":[55],"influence":[57,200,230],"vascular":[59,121],"(genetic":[60],"environmental)":[62],"on":[65,201,231],"progression":[66,202,232],"in":[69,161,205,235],"an":[70,199],"MCI":[71,81,163,207,237],"group":[72,164,208],"during":[73],"a":[74,228],"one-year":[75],"period.":[76],"MATERIAL":[77],"METHODS:":[79],"Fifty-five":[80],"patients":[82],"(30":[83],"men":[84,92],"25":[86],"women)":[87,95],"44":[89],"controls":[90],"(25":[91],"19":[94],"matched":[96],"gender":[99],"were":[102,149,156],"studied.":[103],"Mild":[104],"diagnosed":[108],"according":[109],"Petersen":[111],"criteria":[112],"(Mayo":[113],"Clinic":[114],"Group).":[115],"Neuropsychological":[116],"evaluation":[117],"made.":[119],"Assessed":[120],"included":[124],"hypertension,":[125],"cardiovascular":[126],"disease,":[127],"diabetes,":[128],"cigarette":[129],"smoking,":[130],"hyperlipidaemia,":[131],"hyperhomocysteinaemia":[132,174],"vitamin":[134],"B12":[135],"folate":[137,179],"deficiency.":[138],"Genetic":[139],"(APOE":[142],"polymorphism,":[143],"C677T":[144],"A1298C":[146],"MTHFR":[147],"polymorphisms)":[148],"also":[150],"assessed.":[151],"RESULTS:":[152],"found":[157],"significantly":[158],"more":[159],"often":[160],"(p":[165,171,175,181],"=":[166,172,176,182],"0.041),":[167],"including":[168],"APOE4":[169],"allele":[170],"0.018),":[173],"0.012)":[177],"deficiency":[180],"0.023).":[183],"Discriminant":[184],"function":[185],"analysis":[186],"showed":[187],"that":[188],"only":[189],"age":[190],"hypertension":[192],"are":[193,219],"potential":[194],"which":[196],"within":[209],"one":[210],"year":[211],"prospective":[213],"observation.":[214],"CONCLUSION:":[215],"associated":[220],"but":[224],"do":[225],"not":[226],"significant":[229],"group.":[238]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
