{"id":"https://openalex.org/W10844420","doi":null,"title":"p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.","display_name":"p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W10844420","mag":"10844420","pmid":"https://pubmed.ncbi.nlm.nih.gov/8641358"},"language":"en","primary_location":{"id":"pmid:8641358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8641358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003826371","display_name":"Ravi Salgia","orcid":"https://orcid.org/0000-0001-9643-7626","observed_orcids":["https://orcid.org/0000-0001-9643-7626"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Salgia","raw_affiliation_strings":["Division of Hematologic Malignacies, Dana-Farber Cancer Institute, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematologic Malignacies, Dana-Farber Cancer Institute, Boston, MA 02115","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034151974","display_name":"Martin Sattler","orcid":"https://orcid.org/0000-0001-5053-4199","observed_orcids":["https://orcid.org/0000-0001-5053-4199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sattler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076492419","display_name":"Evan P. Pisick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Pisick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026548190","display_name":"Jian\u2010Liang Li","orcid":"https://orcid.org/0000-0002-6487-081X","observed_orcids":["https://orcid.org/0000-0002-6487-081X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039503690","display_name":"James D. Griffin","orcid":"https://orcid.org/0000-0003-1823-7930","observed_orcids":["https://orcid.org/0000-0003-1823-7930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J D Griffin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3698,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.94774951,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"2","first_page":"310","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p210-bcr-abl","display_name":"p210 BCR-ABL","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/paxillin","display_name":"paxillin","score":0.7720000147819519},{"id":"https://openalex.org/keywords/talin","display_name":"talin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/focal-adhesion-proteins","display_name":"focal adhesion proteins","score":0.9390000104904175},{"id":"https://openalex.org/keywords/protein-complex-assembly","display_name":"protein complex formation","score":0.753000020980835},{"id":"https://openalex.org/keywords/tyrosine-kinase-oncogenes","display_name":"tyrosine kinase oncogenes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/p125fak","display_name":"p125FAK","score":0.753000020980835},{"id":"https://openalex.org/keywords/adhesive-defects","display_name":"adhesive defects","score":0.628000020980835},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C116581196","wikidata":"https://www.wikidata.org/wiki/Q14906591","display_name":"Paxillin","level":4,"score":0.9180829524993896},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.8444591760635376},{"id":"https://openalex.org/C108391706","wikidata":"https://www.wikidata.org/wiki/Q15333532","display_name":"PTK2","level":5,"score":0.7204819917678833},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6697129607200623},{"id":"https://openalex.org/C2777979848","wikidata":"https://www.wikidata.org/wiki/Q424042","display_name":"Vinculin","level":4,"score":0.656058132648468},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.5946983695030212},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4911591708660126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42897191643714905},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.423475980758667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40176689624786377},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34738510847091675},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23493832349777222},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.21641525626182556},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.15978479385375977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10970309376716614},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.07649710774421692},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016608","descriptor_name":"Talin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050721","descriptor_name":"Proto-Oncogene Proteins c-cbl","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051419","descriptor_name":"Paxillin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8641358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8641358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"mag:10844420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8641358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7241699332","display_name":"PAXILLIN--AN ONCOGENE ACTIVATED PROTEIN","funder_award_id":"K08CA060821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1568716429","https://openalex.org/W2293685045","https://openalex.org/W2118030635","https://openalex.org/W203527467","https://openalex.org/W2046548078","https://openalex.org/W2086253117","https://openalex.org/W2053356200","https://openalex.org/W1999819978","https://openalex.org/W125816829","https://openalex.org/W2411406092"],"abstract_inverted_index":{"Chronic":[0],"myelogenous":[1],"leukemia":[2],"(CML)":[3],"is":[4,25,42,108],"a":[5,16,55],"myeloproliferative":[6],"disorder":[7],"caused":[8],"by":[9,40],"the":[10,28,33,43,131,139],"t(9;22)":[11],"translocation.":[12],"This":[13],"translocation":[14],"creates":[15],"unique":[17],"tyrosine":[18,35],"kinase":[19],"oncogene,":[20],"bcr/abl,":[21],"whose":[22],"product,":[23],"p210BCR/ABL,":[24],"localized":[26],"to":[27,91,93,130,138],"actin":[29],"cytoskeleton.":[30],"One":[31],"of":[32,54,58,79,104,128,143],"major":[34],"phosphoproteins":[36],"in":[37,88,95,123],"cells":[38],"transformed":[39],"p210BCR/ABL":[41,51,66],"protooncoprotein":[44],"p120c-Cbl.":[45],"We":[46],"have":[47,98],"previously":[48],"shown":[49],"that":[50,71],"induces":[52],"formation":[53],"multimeric":[56],"complex":[57,97],"proteins":[59,75],"which":[60],"include":[61],"p120c-Cbl,":[62],"phosphotidylinositol-3'":[63],"kinase,":[64],"and":[65,84,119],"itself.":[67],"Here":[68],"we":[69],"show":[70],"certain":[72],"focal":[73,112,132],"adhesion":[74,113,133],"are":[76,121],"also":[77],"part":[78],"this":[80,96,124],"complex,":[81],"including":[82],"paxillin":[83,89,107,135],"talin.":[85],"The":[86,102,126],"sites":[87],"required":[90],"bind":[92],"p120c-Cbl":[94,129],"been":[99],"partially":[100],"mapped.":[101],"interaction":[103],"pl20c-Cbl":[105],"with":[106],"specific,":[109],"since":[110],"other":[111],"proteins,":[114],"such":[115],"as":[116],"p125FAK,":[117],"vinculin,":[118],"alpha-actinin,":[120],"not":[122],"complex.":[125],"binding":[127],"protein":[134],"could":[136],"contribute":[137],"known":[140],"adhesive":[141],"defects":[142],"CML":[144],"cells.":[145]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}