{"id":"https://openalex.org/W108040955","doi":null,"title":"Partial peripheral neuropathy and denervation induced adrenoceptor supersensitivity. Functional studies in an experimental model.","display_name":"Partial peripheral neuropathy and denervation induced adrenoceptor supersensitivity. Functional studies in an experimental model.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W108040955","mag":"108040955","pmid":"https://pubmed.ncbi.nlm.nih.gov/9586253"},"language":"en","primary_location":{"id":"pmid:9586253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9586253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta orthopaedica Belgica","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110255232","display_name":"H. A. J. M. Kurvers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H Kurvers","raw_affiliation_strings":["Department of Surgery, University Hospital Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University Hospital Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103578874","display_name":"Marc A. R. C. Daemen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Daemen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072671255","display_name":"Dick W. Slaaf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Slaaf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087773614","display_name":"Frank R. M. Stassen","orcid":"https://orcid.org/0000-0001-8450-9506","observed_orcids":["https://orcid.org/0000-0001-8450-9506"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Stassen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111749128","display_name":"Frans A.J.M. van den Wildenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F van den Wildenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110107094","display_name":"Peter J.E.H.M. Kitslaar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Kitslaar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049359215","display_name":"Jo G. R. De Mey","orcid":"https://orcid.org/0000-0001-6274-8071","observed_orcids":["https://orcid.org/0000-0001-6274-8071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J de Mey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0971,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.72861221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"64","issue":"1","first_page":"64","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.1826000064611435,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.843999981880188},{"id":"https://openalex.org/keywords/sciatic-nerve-ligation","display_name":"sciatic nerve ligation","score":0.925000011920929},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.7429999709129333},{"id":"https://openalex.org/keywords/complex-regional-pain-syndrome","display_name":"complex regional pain syndrome","score":0.9580000042915344},{"id":"https://openalex.org/keywords/denervation","display_name":"denervation","score":0.753000020980835},{"id":"https://openalex.org/keywords/sympathetic-dysfunction","display_name":"sympathetic dysfunction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/adrenergic-nerve-stimulation","display_name":"adrenergic nerve stimulation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.7540000081062317},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9271713495254517},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.607552170753479},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5637783408164978},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.5516571998596191},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.5200828909873962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5056886672973633},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.5044513940811157},{"id":"https://openalex.org/C2779941686","wikidata":"https://www.wikidata.org/wiki/Q6947930","display_name":"Myograph","level":3,"score":0.48883670568466187},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44860485196113586},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.4213051199913025},{"id":"https://openalex.org/C2776512019","wikidata":"https://www.wikidata.org/wiki/Q1816418","display_name":"Efferent","level":3,"score":0.4101486802101135},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36956900358200073},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18065273761749268},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.15654876828193665},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000316","descriptor_name":"Adrenergic alpha-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000320","descriptor_name":"Adrenergic Fibers","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000320","descriptor_name":"Adrenergic Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003714","descriptor_name":"Denervation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009476","descriptor_name":"Neurons, Efferent","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009476","descriptor_name":"Neurons, Efferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012019","descriptor_name":"Reflex Sympathetic Dystrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012019","descriptor_name":"Reflex Sympathetic Dystrophy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018340","descriptor_name":"Receptors, Adrenergic, alpha-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018340","descriptor_name":"Receptors, Adrenergic, alpha-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9586253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9586253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta orthopaedica Belgica","raw_type":"Comparative Study"},{"id":"pmid:9922532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9922532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta orthopaedica Belgica","raw_type":"Journal Article"},{"id":"mag:108040955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9586253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096202044","https://openalex.org/W1988713166","https://openalex.org/W2000332033","https://openalex.org/W2163369407","https://openalex.org/W2915921677","https://openalex.org/W1994935518","https://openalex.org/W1510869445","https://openalex.org/W2039167467","https://openalex.org/W2056164497","https://openalex.org/W1983037932"],"abstract_inverted_index":{"Sciatic":[0],"nerve":[1,163],"ligation":[2],"in":[3,35,38,45,58,141,160],"rats":[4,68],"(chronic":[5],"constriction":[6],"injury":[7],"(CCI))":[8],"induces":[9],"clinical":[10],"signs":[11],"and":[12,82],"symptoms":[13],"that":[14,138],"mimic":[15],"human":[16],"conditions":[17],"of":[18,55,67,79,87,145,149,156],"neuropathic":[19,146],"origin,":[20],"such":[21],"as":[22,42,44,116],"reflex":[23],"sympathetic":[24,36,56,139,162],"dystrophy":[25],"(RSD).":[26],"Denervation-induced":[27],"supersensitivity":[28,151],"to":[29,75,98,111,118,131,152],"(circulating)":[30],"catecholamines":[31,153],"has":[32],"been":[33],"implicated":[34],"dysfunction":[37,140],"the":[39,48,64,99,105,119,125],"CCI":[40],"model":[41,144],"well":[43],"RSD.":[46],"In":[47],"present":[49],"paper":[50],"we":[51],"studied":[52,92],"functional":[53],"properties":[54],"innervation":[57],"subcutaneous":[59,102,122],"resistance":[60],"arteries,":[61],"isolated":[62],"from":[63,104,124],"hind":[65],"paw":[66],"3":[69],"weeks":[70],"after":[71],"ligation.":[72],"Contractile":[73],"responses":[74],"electric":[76],"field":[77,113],"stimulation":[78],"adrenergic":[80,89],"nerves":[81],"exogenously":[83],"administered":[84],"cumulative":[85],"doses":[86],"various":[88],"agonists":[90],"were":[91,108],"using":[93],"a":[94],"myograph.":[95],"As":[96],"compared":[97,117],"contralateral":[100,120],"side,":[101,121],"arteries":[103,123],"ligated":[106,126],"side":[107,127],"less":[109],"responsive":[110],"electrical":[112],"stimulation.":[114,134],"Besides,":[115],"showed":[128],"increased":[129],"sensitivity":[130],"alpha":[132],"1-adrenoceptor":[133],"This":[135],"study":[136],"demonstrates":[137],"an":[142,157],"experimental":[143],"pain":[147],"consists":[148],"denervation-induced":[150],"rather":[154],"than":[155],"afferently-induced":[158],"increase":[159],"efferent":[161],"impulses.":[164]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
