{"id":"https://openalex.org/W107789808","doi":null,"title":"Chemoradiotherapy for advanced inoperable head and neck cancer: A phase II study.","display_name":"Chemoradiotherapy for advanced inoperable head and neck cancer: A phase II study.","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W107789808","mag":"107789808","pmid":"https://pubmed.ncbi.nlm.nih.gov/10210541"},"language":"en","primary_location":{"id":"pmid:10210541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10210541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in radiation oncology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064995670","display_name":"Prakash B. Chougule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P B Chougule","raw_affiliation_strings":["Brown University Oncology Group, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University Oncology Group, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107864482","display_name":"Muhammad Sohail Akhtar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S Akhtar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016686763","display_name":"Wallace Akerley","orcid":"https://orcid.org/0000-0002-3090-4778","observed_orcids":["https://orcid.org/0000-0002-3090-4778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Akerley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079438136","display_name":"Neal Ready","orcid":"https://orcid.org/0000-0003-4414-9432","observed_orcids":["https://orcid.org/0000-0003-4414-9432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Ready","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013039829","display_name":"Howard P. Safran","orcid":"https://orcid.org/0000-0002-6221-7147","observed_orcids":["https://orcid.org/0000-0002-6221-7147"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Safran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110236497","display_name":"Robert McRae","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R McRae","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016246518","display_name":"Peter T. Nigri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Nigri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078354849","display_name":"Joseph P. Bellino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Bellino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085552557","display_name":"James Koness","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Koness","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109985758","display_name":"Kathy Radie-Keane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Radie-Keane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109561731","display_name":"Harold J. Wanebo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Wanebo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1005,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.96113074,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"9","issue":"2 Suppl 1","first_page":"58","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9190000295639038},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":1.0},{"id":"https://openalex.org/keywords/unresectable-tumors","display_name":"unresectable tumors","score":0.7049999833106995},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/locoregional-control","display_name":"locoregional control","score":0.8299999833106995},{"id":"https://openalex.org/keywords/mucositis","display_name":"mucositis","score":0.6430000066757202},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.7820000052452087},{"id":"https://openalex.org/keywords/neck-dissection","display_name":"neck dissection","score":0.7260000109672546},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9784218072891235},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.8947751522064209},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.8369624614715576},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.6800302863121033},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.610069215297699},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5686490535736084},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5623527765274048},{"id":"https://openalex.org/C2778474501","wikidata":"https://www.wikidata.org/wiki/Q355817","display_name":"Neck dissection","level":3,"score":0.47463592886924744},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42957425117492676},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.42792823910713196},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4225611686706543},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3548728823661804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3288126587867737},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.14860087633132935},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10210541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10210541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in radiation oncology","raw_type":"Clinical Trial"},{"id":"mag:107789808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10210541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2414994681","https://openalex.org/W1998325429","https://openalex.org/W2418190568","https://openalex.org/W2258655328","https://openalex.org/W2167287546","https://openalex.org/W2119126342","https://openalex.org/W2004895076","https://openalex.org/W2242885600","https://openalex.org/W2017626564","https://openalex.org/W2143359989"],"abstract_inverted_index":{"The":[0,166,313],"beneficial":[1],"effects":[2],"of":[3,17,30,77,101,112,151,193,197,214,247],"chemotherapy":[4],"in":[5,15,24,72,139,177,185,245],"patients":[6,127,136,155,179,200,217],"with":[7,52,114,130,147,218,270],"advanced":[8],"head":[9],"and":[10,28,39,50,59,75,144,181,209,265,281,296,302,310],"neck":[11,123,221,226],"cancer":[12],"remain":[13],"controversial":[14],"terms":[16],"survival,":[18,40],"but":[19,291],"have":[20,61,201],"shown":[21,63],"some":[22],"promise":[23],"improving":[25],"locoregional":[26,37],"control":[27,38],"quality":[29],"life.":[31],"In":[32],"an":[33,189],"effort":[34],"to":[35,92],"improve":[36],"a":[41,148],"prospective":[42],"phase":[43,74],"II":[44],"study":[45,314],"was":[46,120,170,234],"initiated":[47],"using":[48],"paclitaxel":[49,103],"carboplatin":[51,60,106],"concurrent":[53],"conventional":[54,115],"fractionated":[55],"external-beam":[56,297],"radiotherapy.":[57],"Paclitaxel":[58],"both":[62],"excellent":[64,300],"radiosensitization":[65],"through":[66],"two":[67],"discrete":[68],"mechanisms,":[69],"cell":[70],"blockage":[71],"G2/M":[73],"inhibition":[76],"DNA":[78],"repair,":[79],"respectively.":[80],"Patients":[81],"were":[82,137,211],"stratified":[83],"as":[84],"either":[85],"operable":[86],"or":[87,241,255],"inoperable.":[88],"This":[89],"report":[90],"pertains":[91],"the":[93,109,205,215,235,248,307],"inoperable":[94],"patient":[95,269],"group,":[96],"who":[97,128,273],"received":[98],"eight":[99],"cycles":[100],"weekly":[102],"(60":[104],"mg/m2),":[105],"(area":[107],"under":[108],"concentration-time":[110],"curve":[111],"1)":[113],"radiotherapy":[116,298],"(72":[117],"Gy).":[118],"Chemoradiotherapy":[119],"followed":[121],"by":[122],"dissection":[124],"for":[125,188,317],"those":[126],"presented":[129],"clinically":[131,219],"palpable":[132,220],"lymph":[133],"nodes.":[134,232],"Thirty-three":[135],"enrolled":[138],"this":[140],"group":[141],"(23":[142],"men":[143],"10":[145,186],"women":[146],"median":[149,167],"age":[150],"56":[152],"years).":[153],"Eleven":[154],"(33%)":[156],"had":[157,230,274],"stage":[158,163],"III":[159],"disease;":[160],"22":[161],"(67%),":[162],"IV":[164],"disease.":[165],"follow-up":[168],"period":[169],"14":[171],"months.":[172],"Clinical":[173],"complete":[174,276],"response":[175,183,191,277],"occurred":[176,184,244],"20":[178],"(60%)":[180],"partial":[182],"(30%),":[187],"overall":[190],"rate":[192],"90%.":[194],"Following":[195],"completion":[196],"therapy,":[198],"18":[199],"undergone":[202],"biopsy":[203],"at":[204,223],"primary":[206],"tumor":[207],"site":[208],"17":[210],"negative.":[212],"Eight":[213],"16":[216],"nodes":[222],"presentation":[224],"underwent":[225],"dissection;":[227],"five":[228],"(63%)":[229],"negative":[231],"Mucositis":[233,305],"most":[236,308],"common":[237,309],"toxicity.":[238],"Grade":[239],"3":[240,254],"4":[242,256],"mucositis":[243],"30":[246],"33":[249],"(90%)":[250],"patients.":[251],"Other":[252],"grade":[253],"toxicities":[257],"included":[258],"skin":[259],"(22%),":[260],"candidiasis":[261],"(19%),":[262],"neutropenia":[263],"(9%),":[264],"dehydration":[266],"(6%).":[267],"One":[268],"laryngeal":[271],"carcinoma":[272],"pathologic":[275,303],"developed":[278],"cartilage":[279],"necrosis":[280],"is":[282],"undergoing":[283],"hyperbaric":[284],"oxygen":[285],"therapy.":[286],"Survival":[287],"data":[288],"are":[289],"early":[290],"encouraging.":[292],"Concurrent":[293],"paclitaxel,":[294],"carboplatin,":[295],"yielded":[299],"clinical":[301],"responses.":[304],"remains":[306],"significant":[311],"morbidity.":[312],"will":[315],"continue":[316],"necessary":[318],"accrual.":[319]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}