{"id":"https://openalex.org/W10774823","doi":null,"title":"Differential Regulation of host cellular gene expression by HIV-1 Viral protein R (Vpr): Implications for host cell function","display_name":"Differential Regulation of host cellular gene expression by HIV-1 Viral protein R (Vpr): Implications for host cell function","publication_year":2006,"publication_date":"2006-02-16","ids":{"openalex":"https://openalex.org/W10774823","mag":"10774823"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10250","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10250/1/JanketML_etd2005.pdf","pdf_url":"http://d-scholarship.pitt.edu/10250/1/JanketML_etd2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/10250/1/JanketML_etd2005.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001577330","display_name":"Michelle L. Janket","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michelle L. Janket","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001577330"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0004635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-vpr","display_name":"HIV-1 Vpr","score":0.8989999890327454},{"id":"https://openalex.org/keywords/host-gene-expression-regulation","display_name":"host gene expression regulation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/nhe1","display_name":"NHE1","score":0.7609999775886536},{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.8349999785423279},{"id":"https://openalex.org/keywords/akt-kinase","display_name":"Akt kinase","score":0.6800000071525574},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/bystander-cell-death","display_name":"bystander cell death","score":0.9620000123977661},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8980000019073486},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.7160000205039978},{"id":"https://openalex.org/keywords/tnf-alpha-promoter-polymorphism","display_name":"TNF-alpha promoter polymorphism","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hiv-pathogenesis","display_name":"HIV pathogenesis","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7024604678153992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5852907299995422},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.570790708065033},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5307528972625732},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5279159545898438},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4719128906726837},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.44410938024520874},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4335474371910095},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4228728115558624},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3770022690296173},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20219293236732483}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:10250","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10250/1/JanketML_etd2005.pdf","pdf_url":"http://d-scholarship.pitt.edu/10250/1/JanketML_etd2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:10774823","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/10250/1/JanketML_etd2005.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10250","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10250/1/JanketML_etd2005.pdf","pdf_url":"http://d-scholarship.pitt.edu/10250/1/JanketML_etd2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3366330198","display_name":null,"funder_award_id":"ES 00202","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W10774823.pdf","grobid_xml":"https://content.openalex.org/works/W10774823.grobid-xml"},"referenced_works_count":304,"referenced_works":["https://openalex.org/W4850913","https://openalex.org/W99900737","https://openalex.org/W129952482","https://openalex.org/W1480160846","https://openalex.org/W1480448067","https://openalex.org/W1487143054","https://openalex.org/W1498574963","https://openalex.org/W1508115229","https://openalex.org/W1524302630","https://openalex.org/W1524602398","https://openalex.org/W1525739154","https://openalex.org/W1526363252","https://openalex.org/W1527094712","https://openalex.org/W1528266646","https://openalex.org/W1551750271","https://openalex.org/W1552146516","https://openalex.org/W1559159023","https://openalex.org/W1571744798","https://openalex.org/W1573886646","https://openalex.org/W1576999979","https://openalex.org/W1578935297","https://openalex.org/W1588560093","https://openalex.org/W1602191622","https://openalex.org/W1606519969","https://openalex.org/W1623326129","https://openalex.org/W1657655805","https://openalex.org/W1683590180","https://openalex.org/W1770932653","https://openalex.org/W1771551752","https://openalex.org/W1785639469","https://openalex.org/W1806998329","https://openalex.org/W1807747199","https://openalex.org/W1811023533","https://openalex.org/W1841847537","https://openalex.org/W1848911348","https://openalex.org/W1911317520","https://openalex.org/W1925504181","https://openalex.org/W1954751611","https://openalex.org/W1963705823","https://openalex.org/W1964065999","https://openalex.org/W1964686065","https://openalex.org/W1965130034","https://openalex.org/W1965131361","https://openalex.org/W1967169657","https://openalex.org/W1967254323","https://openalex.org/W1967737680","https://openalex.org/W1969070574","https://openalex.org/W1969140805","https://openalex.org/W1971886669","https://openalex.org/W1973208298","https://openalex.org/W1973782438","https://openalex.org/W1974393084","https://openalex.org/W1976035792","https://openalex.org/W1976310915","https://openalex.org/W1976392964","https://openalex.org/W1977055673","https://openalex.org/W1977282539","https://openalex.org/W1977705956","https://openalex.org/W1978086671","https://openalex.org/W1979816305","https://openalex.org/W1980209394","https://openalex.org/W1980213362","https://openalex.org/W1980214977","https://openalex.org/W1980962192","https://openalex.org/W1981440980","https://openalex.org/W1982060052","https://openalex.org/W1983163687","https://openalex.org/W1983747887","https://openalex.org/W1985922024","https://openalex.org/W1986232807","https://openalex.org/W1986415814","https://openalex.org/W1987064455","https://openalex.org/W1987416684","https://openalex.org/W1989560607","https://openalex.org/W1989670405","https://openalex.org/W1989819854","https://openalex.org/W1990069685","https://openalex.org/W1991069890","https://openalex.org/W1991345502","https://openalex.org/W1991670386","https://openalex.org/W1992036920","https://openalex.org/W1992095999","https://openalex.org/W1992142989","https://openalex.org/W1992679195","https://openalex.org/W1992984336","https://openalex.org/W1994473067","https://openalex.org/W1995303015","https://openalex.org/W1995304304","https://openalex.org/W1995754186","https://openalex.org/W1997578300","https://openalex.org/W2000362582","https://openalex.org/W2001046375","https://openalex.org/W2001243226","https://openalex.org/W2001375348","https://openalex.org/W2001669885","https://openalex.org/W2001675486","https://openalex.org/W2001789973","https://openalex.org/W2002056641","https://openalex.org/W2002739495","https://openalex.org/W2005298510","https://openalex.org/W2007150582","https://openalex.org/W2007984616","https://openalex.org/W2008954911","https://openalex.org/W2009104414","https://openalex.org/W2009659265","https://openalex.org/W2009905886","https://openalex.org/W2010081774","https://openalex.org/W2010840723","https://openalex.org/W2011104403","https://openalex.org/W2013203169","https://openalex.org/W2014818809","https://openalex.org/W2015937408","https://openalex.org/W2016681270","https://openalex.org/W2016723478","https://openalex.org/W2016932468","https://openalex.org/W2017447440","https://openalex.org/W2018832587","https://openalex.org/W2019126794","https://openalex.org/W2023335145","https://openalex.org/W2023991533","https://openalex.org/W2024351189","https://openalex.org/W2024569169","https://openalex.org/W2024664208","https://openalex.org/W2025761825","https://openalex.org/W2026057161","https://openalex.org/W2026961149","https://openalex.org/W2027214164","https://openalex.org/W2027459341","https://openalex.org/W2028509264","https://openalex.org/W2029299482","https://openalex.org/W2030467317","https://openalex.org/W2031178654","https://openalex.org/W2033872291","https://openalex.org/W2034660792","https://openalex.org/W2035722382","https://openalex.org/W2036565444","https://openalex.org/W2039380803","https://openalex.org/W2040313539","https://openalex.org/W2040706842","https://openalex.org/W2041192584","https://openalex.org/W2041367110","https://openalex.org/W2041446234","https://openalex.org/W2042358762","https://openalex.org/W2043760057","https://openalex.org/W2043852388","https://openalex.org/W2044360533","https://openalex.org/W2044686508","https://openalex.org/W2045070830","https://openalex.org/W2047951231","https://openalex.org/W2048656467","https://openalex.org/W2049314466","https://openalex.org/W2049958866","https://openalex.org/W2052022412","https://openalex.org/W2052060811","https://openalex.org/W2052119995","https://openalex.org/W2052139158","https://openalex.org/W2052659154","https://openalex.org/W2052938761","https://openalex.org/W2053294769","https://openalex.org/W2053332066","https://openalex.org/W2054007006","https://openalex.org/W2054298180","https://openalex.org/W2055078115","https://openalex.org/W2055157443","https://openalex.org/W2057567758","https://openalex.org/W2057782528","https://openalex.org/W2058097057","https://openalex.org/W2059524588","https://openalex.org/W2060952336","https://openalex.org/W2061910719","https://openalex.org/W2062356412","https://openalex.org/W2064495999","https://openalex.org/W2064557078","https://openalex.org/W2066037401","https://openalex.org/W2066280128","https://openalex.org/W2069521922","https://openalex.org/W2071692640","https://openalex.org/W2073140901","https://openalex.org/W2074541621","https://openalex.org/W2074634235","https://openalex.org/W2075517790","https://openalex.org/W2076634735","https://openalex.org/W2078441282","https://openalex.org/W2079704545","https://openalex.org/W2079845661","https://openalex.org/W2080117718","https://openalex.org/W2080774901","https://openalex.org/W2081494228","https://openalex.org/W2082737563","https://openalex.org/W2084700723","https://openalex.org/W2085546756","https://openalex.org/W2085992210","https://openalex.org/W2086725873","https://openalex.org/W2087480936","https://openalex.org/W2087809591","https://openalex.org/W2088598615","https://openalex.org/W2088773368","https://openalex.org/W2089135460","https://openalex.org/W2089395108","https://openalex.org/W2090407774","https://openalex.org/W2091621138","https://openalex.org/W2091660627","https://openalex.org/W2092658269","https://openalex.org/W2094023425","https://openalex.org/W2094347764","https://openalex.org/W2095679834","https://openalex.org/W2096550955","https://openalex.org/W2097074610","https://openalex.org/W2097080670","https://openalex.org/W2097213667","https://openalex.org/W2097744772","https://openalex.org/W2097797047","https://openalex.org/W2097799740","https://openalex.org/W2098625990","https://openalex.org/W2099277378","https://openalex.org/W2100445170","https://openalex.org/W2101157641","https://openalex.org/W2101296785","https://openalex.org/W2103156261","https://openalex.org/W2104679205","https://openalex.org/W2104730528","https://openalex.org/W2105369844","https://openalex.org/W2105893126","https://openalex.org/W2105935286","https://openalex.org/W2106527981","https://openalex.org/W2107599574","https://openalex.org/W2107911156","https://openalex.org/W2107952852","https://openalex.org/W2108498026","https://openalex.org/W2108857688","https://openalex.org/W2109324904","https://openalex.org/W2109928526","https://openalex.org/W2109941804","https://openalex.org/W2111194763","https://openalex.org/W2112745816","https://openalex.org/W2112771109","https://openalex.org/W2114021619","https://openalex.org/W2114170740","https://openalex.org/W2115979107","https://openalex.org/W2116242441","https://openalex.org/W2118682821","https://openalex.org/W2119717842","https://openalex.org/W2122266844","https://openalex.org/W2122310985","https://openalex.org/W2123750058","https://openalex.org/W2124262038","https://openalex.org/W2124585743","https://openalex.org/W2127815795","https://openalex.org/W2127930176","https://openalex.org/W2130200446","https://openalex.org/W2131222990","https://openalex.org/W2131830910","https://openalex.org/W2132877537","https://openalex.org/W2133140574","https://openalex.org/W2134229904","https://openalex.org/W2136308095","https://openalex.org/W2138112338","https://openalex.org/W2138567519","https://openalex.org/W2141705346","https://openalex.org/W2141972266","https://openalex.org/W2142918729","https://openalex.org/W2143250875","https://openalex.org/W2144150070","https://openalex.org/W2146084524","https://openalex.org/W2146187278","https://openalex.org/W2147114673","https://openalex.org/W2147140511","https://openalex.org/W2149138273","https://openalex.org/W2149224197","https://openalex.org/W2149643442","https://openalex.org/W2149951876","https://openalex.org/W2151897888","https://openalex.org/W2153097311","https://openalex.org/W2160030189","https://openalex.org/W2162531088","https://openalex.org/W2163644060","https://openalex.org/W2163757819","https://openalex.org/W2164718599","https://openalex.org/W2165868393","https://openalex.org/W2168677900","https://openalex.org/W2169963834","https://openalex.org/W2170854597","https://openalex.org/W2170984138","https://openalex.org/W2171268838","https://openalex.org/W2171662092","https://openalex.org/W2171956461","https://openalex.org/W2181516856","https://openalex.org/W2181940400","https://openalex.org/W2258524519","https://openalex.org/W2276617466","https://openalex.org/W2283006953","https://openalex.org/W2285037931","https://openalex.org/W2314491483","https://openalex.org/W2321171642","https://openalex.org/W2322219245","https://openalex.org/W2324473093","https://openalex.org/W2397091981","https://openalex.org/W2400771978","https://openalex.org/W2410713675","https://openalex.org/W2414075451","https://openalex.org/W2463530587","https://openalex.org/W2580620619","https://openalex.org/W2735667336","https://openalex.org/W4299506417"],"related_works":["https://openalex.org/W2061910719","https://openalex.org/W4391480034","https://openalex.org/W1777570062","https://openalex.org/W2155829745","https://openalex.org/W2016638041","https://openalex.org/W2166676812","https://openalex.org/W1574829782","https://openalex.org/W2361779502","https://openalex.org/W2120357014","https://openalex.org/W7098019516"],"abstract_inverted_index":{"The":[0,15,170,188],"HIV/AIDS":[1],"epidemic":[2],"is":[3,178],"one":[4],"of":[5,17,35,44,47,49,64,99,106,142,165,172,176,186,230,237,277,300,306,331],"the":[6,28,45,50,65,88,134,140,162,166,183,255,272,280,298,304,317,329],"most":[7],"important":[8],"public":[9],"health":[10],"problems":[11],"facing":[12],"this":[13,307],"generation.":[14],"failure":[16],"recent":[18],"vaccine":[19],"trials":[20],"and":[21,75,113,136,261,274,296,323],"growing":[22],"resistance":[23],"to":[24,86,180,182,215],"anti-retroviral":[25,332],"drugs":[26],"underscores":[27],"need":[29],"for":[30,119,313,328],"novel":[31],"therapeutic":[32],"strategies.":[33],"Design":[34],"such":[36],"therapies":[37],"will":[38],"depend":[39],"on":[40,90,279],"a":[41,61,149,159,196,266,310],"detailed":[42,62],"understanding":[43],"mechanism":[46],"action":[48],"HIV-1":[51,66,321,335],"gene":[52,93,110],"products.":[53],"To":[54],"further":[55,117],"that":[56,287],"goal,":[57],"we":[58],"have":[59],"undertaken":[60],"investigation":[63],"viral":[67],"protein":[68,135],"R":[69],"(Vpr).":[70],"We":[71],"employed":[72],"cDNA":[73],"microarray":[74],"antibody":[76],"array":[77],"analyses":[78],"using":[79],"isogenic":[80,223],"virus":[81,205,224],"with":[82,148,203,222,235],"or":[83],"without":[84],"Vpr":[85,95,226,247,278,322],"determine":[87],"effect":[89,276],"host":[91,288,318],"cellular":[92,101],"expression.":[94,227],"induced":[96,315],"differential":[97],"regulation":[98,245],"109":[100],"genes":[102],"representing":[103],"diverse":[104],"families":[105],"signaling":[107],"molecules.":[108],"Two":[109,252],"products,":[111],"NHE1":[112,126,145,177],"TNF":[114,191,211,231,243,256,281],"alpha,":[115],"were":[116,263],"studied":[118],"their":[120,219],"potential":[121,326],"roles":[122],"in":[123,139,153,161,198,213,239,248,254,269,316],"Vpr-mediated":[124,144,199],"apoptosis.":[125,200],"expression":[127],"was":[128],"decreased":[129],"by":[130,246,320],"50%":[131],"at":[132,265],"both":[133],"mRNA":[137],"levels":[138],"presence":[141],"Vpr.":[143,187,336],"downregulation":[146],"correlated":[147,234],"dose":[150],"dependent":[151],"decrease":[152,160],"intracellular":[154],"pH":[155],"as":[156,158],"well":[157],"active":[163],"form":[164],"pro-survival":[167],"kinase":[168],"Akt.":[169],"loss":[171],"these":[173],"anti-apoptotic":[174],"functions":[175],"proposed":[179],"contribute":[181],"apoptotic":[184],"role":[185],"pro-inflammatory":[189],"cytokine":[190],"alpha":[192,212,232,244,257,282],"may":[193,291],"also":[194],"play":[195],"part":[197],"Macrophages":[201],"infected":[202,221],"vpr-expressing":[204],"secreted":[206],"1.1-8.5":[207],"fold":[208],"more":[209],"soluble":[210],"response":[214],"LPS":[216],"stimulation":[217],"than":[218],"counterparts":[220],"lacking":[225],"Fold":[228],"upregulation":[229],"directly":[233],"induction":[236],"apoptosis":[238],"uninfected":[240],"lymphocytes,":[241],"implicating":[242],"bystander":[249,293],"cell":[250,294,319],"death.":[251],"polymorphisms":[253],"promoter,":[258],"positions":[259],"-238":[260],"-963,":[262],"found":[264],"higher":[267],"prevalence":[268],"donors":[270],"showing":[271],"lowest":[273],"highest":[275],"response.":[283],"These":[284],"results":[285,305],"suggest":[286],"genetic":[289],"determinants":[290],"affect":[292],"death":[295],"thus":[297],"course":[299],"HIV":[301],"pathogenesis.":[302],"Together,":[303],"study":[308],"present":[309],"molecular":[311],"basis":[312],"changes":[314],"elucidate":[324],"two":[325],"pathways":[327],"design":[330],"therapeutics":[333],"targeting":[334]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
