{"id":"https://openalex.org/W1075423","doi":"https://doi.org/10.1042/bj1500413","title":"Effect of protein-synthesis inhibitors on testosterone production in rat testis interstitial tissue and Leydig-cell preparations","display_name":"Effect of protein-synthesis inhibitors on testosterone production in rat testis interstitial tissue and Leydig-cell preparations","publication_year":1975,"publication_date":"1975-09-01","ids":{"openalex":"https://openalex.org/W1075423","doi":"https://doi.org/10.1042/bj1500413","mag":"1075423","pmid":"https://pubmed.ncbi.nlm.nih.gov/174545","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1165756"},"language":"en","primary_location":{"id":"doi:10.1042/bj1500413","doi":"https://doi.org/10.1042/bj1500413","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1500413","pdf_url":"https://portlandpress.com/biochemj/article-pdf/150/3/413/565792/bj1500413.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/150/3/413/565792/bj1500413.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109918783","display_name":"BRIAN A. COOKE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"B A Cooke","raw_affiliation_strings":["Department of Biochemistry (Division of Chemical Endocrinology), Medical Faculty, Erasmus University Rotterdam, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry (Division of Chemical Endocrinology), Medical Faculty, Erasmus University Rotterdam, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017072016","display_name":"Felix H. A. Janszen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F H Janszen","raw_affiliation_strings":["Department of Biochemistry (Division of Chemical Endocrinology), Medical Faculty, Erasmus University Rotterdam, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry (Division of Chemical Endocrinology), Medical Faculty, Erasmus University Rotterdam, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086937911","display_name":"W.F. Clotscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W F Clotscher","raw_affiliation_strings":["Department of Biochemistry (Division of Chemical Endocrinology), Medical Faculty, Erasmus University Rotterdam, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry (Division of Chemical Endocrinology), Medical Faculty, Erasmus University Rotterdam, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012764347","display_name":"Henk J. van der Molen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H J van der Molen","raw_affiliation_strings":["Department of Biochemistry (Division of Chemical Endocrinology), Medical Faculty, Erasmus University Rotterdam, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry (Division of Chemical Endocrinology), Medical Faculty, Erasmus University Rotterdam, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I913958620"],"apc_list":null,"apc_paid":null,"fwci":5.7058,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.95494302,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"150","issue":"3","first_page":"413","last_page":"418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testosterone-production","display_name":"testosterone production","score":0.8610000014305115},{"id":"https://openalex.org/keywords/protein-synthesis-inhibitors","display_name":"protein synthesis inhibitors","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.9359999895095825},{"id":"https://openalex.org/keywords/puromycin","display_name":"puromycin","score":1.0},{"id":"https://openalex.org/keywords/chloramphenicol","display_name":"chloramphenicol","score":0.9909999966621399},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/testicular-interstitial-tissue","display_name":"testicular interstitial tissue","score":0.9169999957084656},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.8970000147819519},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8119999766349792},{"id":"https://openalex.org/keywords/first-order-kinetics","display_name":"first-order kinetics","score":0.6439999938011169},{"id":"https://openalex.org/keywords/rat-testis","display_name":"rat testis","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.7814128994941711},{"id":"https://openalex.org/C2777534427","wikidata":"https://www.wikidata.org/wiki/Q6057165","display_name":"Interstitial cell","level":2,"score":0.6999294757843018},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.676384449005127},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5273438692092896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5088505744934082},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.5016274452209473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49245938658714294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3836022913455963},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33379775285720825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30085331201553345},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.20240315794944763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11328718066215515},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.08261197805404663}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002701","descriptor_name":"Chloramphenicol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011691","descriptor_name":"Puromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj1500413","doi":"https://doi.org/10.1042/bj1500413","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1500413","pdf_url":"https://portlandpress.com/biochemj/article-pdf/150/3/413/565792/bj1500413.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1165756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1165756","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:174545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/174545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj1500413","doi":"https://doi.org/10.1042/bj1500413","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1500413","pdf_url":"https://portlandpress.com/biochemj/article-pdf/150/3/413/565792/bj1500413.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1075423.pdf","grobid_xml":"https://content.openalex.org/works/W1075423.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W25047711","https://openalex.org/W30517551","https://openalex.org/W1521882551","https://openalex.org/W1532140047","https://openalex.org/W1583788306","https://openalex.org/W1588180482","https://openalex.org/W1775749144","https://openalex.org/W1963598422","https://openalex.org/W1964423926","https://openalex.org/W1967799268","https://openalex.org/W1982425063","https://openalex.org/W2004994757","https://openalex.org/W2021461380","https://openalex.org/W2039803215","https://openalex.org/W2040028421","https://openalex.org/W2041903250","https://openalex.org/W2046728975","https://openalex.org/W2076384435","https://openalex.org/W2081487791","https://openalex.org/W2086463293","https://openalex.org/W2088025053","https://openalex.org/W2103684647","https://openalex.org/W2132966886","https://openalex.org/W6835264232"],"related_works":["https://openalex.org/W191933770","https://openalex.org/W2067127228","https://openalex.org/W2032117221","https://openalex.org/W2399578487","https://openalex.org/W1521882551","https://openalex.org/W2189257188","https://openalex.org/W2026692348","https://openalex.org/W1963966042","https://openalex.org/W1964686931","https://openalex.org/W2092759687"],"abstract_inverted_index":{"Luteinizing-hormone-stimulated":[0],"testosterone":[1,98,135,162,179],"biosynthesis":[2],"was":[3,108,171],"inhibited":[4],"by":[5,18,29,39,69,100],"cycloheximide":[6,21,55,89],"during":[7,22,103],"incubation":[8,23],"of":[9,24,54,72,80,86,88,97,105,117,156,167,178,182],"rat":[10,49],"testis":[11],"intersitial":[12],"tissue":[13,107],"in":[14,45,47,134,164],"vitro":[15],"and":[16,20,56,75,83,113,120],"also":[17],"puromycin":[19,57,158],"Leydig-cell":[25],"preparations,":[26],"but":[27],"not":[28],"chloramphenicol.":[30],"These":[31],"results":[32],"suggest":[33],"that":[34,146,174],"a":[35,115,131,151],"protein":[36,41,59,73,148,183],"regualtor(s)":[37],"formed":[38],"cytoplasmic":[40],"synthesis":[42,60,74,136],"is":[43,67,180],"involved":[44],"steroidogenesis":[46,76],"the":[48,70,81,84,147,165,175],"testis.":[50],"The":[51],"specific":[52],"effect":[53,87,155],"on":[58,63,90,161],"rather":[61],"than":[62],"other":[64],"non-specific":[65],"processes":[66],"suggested":[68],"inhibition":[71],"with":[77],"different":[78],"doses":[79],"inhibitors":[82],"lack":[85],"luteinizing-hormone-induced":[91],"adenosine":[92],"3':5'-cyclic":[93],"monophosphate":[94],"production.":[95],"Stimulation":[96],"production":[99,129,163,177],"luteinizing":[101,169],"hormone":[102,170],"superfusion":[104],"interstitial":[106],"detectable":[109],"within":[110],"10-20":[111],"min":[112],"reached":[114],"maximum":[116,127],"120":[118],"min,":[119],"thereafter":[121],"slowly":[122],"decreased.":[123],"Cycloheximide":[124],"added":[125,168],"at":[126],"steroid":[128],"caused":[130],"rapid":[132],"decrease":[133],"which":[137],"followed":[138],"first-order":[139],"kinetics":[140],"(half-life":[141],"13":[142],"min),":[143],"thus":[144],"indicating":[145],"regulator(s)":[149],"has":[150],"short":[152],"half-life.":[153],"No":[154],"cycloheximide,":[157],"or":[159],"chloramphenicol":[160],"absence":[166],"found,":[172],"suggesting":[173],"basal":[176],"independent":[181],"synthesis.":[184]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
