{"id":"https://openalex.org/W107529972","doi":null,"title":"TACE of liver metastases from colorectal cancer adopting irinotecan-eluting beads: beneficial effect of palliative intra-arterial lidocaine and post-procedure supportive therapy on the control of side effects.","display_name":"TACE of liver metastases from colorectal cancer adopting irinotecan-eluting beads: beneficial effect of palliative intra-arterial lidocaine and post-procedure supportive therapy on the control of side effects.","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W107529972","mag":"107529972","pmid":"https://pubmed.ncbi.nlm.nih.gov/19260480"},"language":"en","primary_location":{"id":"pmid:19260480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19260480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070566745","display_name":"Giammaria Fiorentini","orcid":"https://orcid.org/0000-0002-5615-889X","observed_orcids":["https://orcid.org/0000-0002-5615-889X"]},"institutions":[{"id":"https://openalex.org/I4210092451","display_name":"Azienda Unit\u00e0 Sanitaria Locale 11 di Empoli","ror":"https://ror.org/00h2j5q24","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210092451"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giammaria Fiorentini","raw_affiliation_strings":["Department of Oncology, San Giuseppe Hospital, Azienda Sanitaria Locale 11, Empoli, Florence, Italy. oncologiaempoli@usl11.tos.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, San Giuseppe Hospital, Azienda Sanitaria Locale 11, Empoli, Florence, Italy. oncologiaempoli@usl11.tos.it","institution_ids":["https://openalex.org/I4210092451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016984915","display_name":"Camillo Aliberti","orcid":"https://orcid.org/0000-0002-0941-7457","observed_orcids":["https://orcid.org/0000-0002-0941-7457"]},"institutions":[{"id":"https://openalex.org/I4210109345","display_name":"Istituto Oncologico Veneto","ror":"https://ror.org/01xcjmy57","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109345","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Camillo Aliberti","raw_affiliation_strings":["Istituto Oncologico Veneto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Oncologico Veneto","institution_ids":["https://openalex.org/I4210109345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050577412","display_name":"Giorgio Benea","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgio Benea","raw_affiliation_strings":["Delta Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delta Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francesco Montagnani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148804","display_name":"Ospedale San Giuseppe","ror":"https://ror.org/05m6e7d23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210148804","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Montagnani","raw_affiliation_strings":["San Giuseppe Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Giuseppe Hospital","institution_ids":["https://openalex.org/I4210148804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081700550","display_name":"Andrea Mambrini","orcid":"https://orcid.org/0000-0001-9736-4991","observed_orcids":["https://orcid.org/0000-0001-9736-4991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Mambrini","raw_affiliation_strings":["General City Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General City Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089891255","display_name":"Pier Luigi Ballardini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pier Luigi Ballardini","raw_affiliation_strings":["Delta Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delta Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043872623","display_name":"Maurizio Cantore","orcid":"https://orcid.org/0000-0002-3360-499X","observed_orcids":["https://orcid.org/0000-0002-3360-499X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maurizio Cantore","raw_affiliation_strings":["General City Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General City Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8414,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.84887636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"55","issue":"88","first_page":"2077","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.09629999846220016,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.9160000085830688},{"id":"https://openalex.org/keywords/colorectal-liver-metastases","display_name":"colorectal liver metastases","score":0.7770000100135803},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.6740000247955322},{"id":"https://openalex.org/keywords/supportive-therapy","display_name":"supportive therapy","score":0.6959999799728394},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.5120000243186951},{"id":"https://openalex.org/keywords/abdominal-pain","display_name":"abdominal pain","score":0.7390000224113464},{"id":"https://openalex.org/keywords/antiemetic-prophylaxis","display_name":"antiemetic prophylaxis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/antibiotic-prophylaxis","display_name":"antibiotic prophylaxis","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9606035351753235},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.6993961930274963},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6713510751724243},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.6627252697944641},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5305562019348145},{"id":"https://openalex.org/C2778455285","wikidata":"https://www.wikidata.org/wiki/Q221788","display_name":"Transcatheter arterial chemoembolization","level":3,"score":0.489327609539032},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42494603991508484},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3642868995666504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3539734482765198},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3443661332130432},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.158962219953537}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010166","descriptor_name":"Palliative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016461","descriptor_name":"Chemoembolization, Therapeutic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19260480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19260480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Clinical Trial"},{"id":"mag:107529972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19260480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2139336946","https://openalex.org/W2556127780","https://openalex.org/W2158500499","https://openalex.org/W35010430","https://openalex.org/W3080493019","https://openalex.org/W2527134189","https://openalex.org/W2241606078","https://openalex.org/W2586417811","https://openalex.org/W2535711995","https://openalex.org/W2122755159"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Colorectal":[1],"cancer":[2,18,83],"is":[3,163],"one":[4],"of":[5,27,54,68,114,138,140,168,171],"the":[6,37,52,124,188],"most":[7,132,146],"significant":[8],"health":[9],"emerging":[10],"problem":[11],"in":[12,24,51,74,118,199],"western":[13],"countries.":[14],"Patients":[15],"with":[16,70,92,112,134,155,202],"colorectal":[17,82],"have":[19],"liver":[20,34,79,203],"metastases":[21,80,204],"at":[22],"presentation":[23],"about":[25],"25%":[26],"cases":[28],"and":[29,95,157,160,173,181],"another":[30],"50%":[31],"will":[32],"develop":[33],"recurrence":[35],"within":[36],"next":[38],"5":[39],"years.":[40],"Intra-arterial":[41],"hepatic":[42],"chemoembolization":[43],"(TACE)":[44],"could":[45],"be":[46,185],"a":[47,65,107,135],"new":[48],"therapeutic":[49],"opportunity":[50],"treatment":[53,91,154],"unresectable":[55],"or":[56],"chemorefractory":[57],"metastases.":[58],"METHODOLOGY:":[59],"Since":[60],"November":[61],"2005":[62],"we":[63],"performed":[64],"clinical":[66],"trial":[67],"TACE":[69,127,195],"irinotecan-eluting":[71],"beads":[72],"(DEBIRI)":[73],"20":[75],"patients":[76,133,201],"affected":[77],"by":[78,131],"from":[81,205],"as":[84,179],"palliative":[85],"setting.":[86],"We":[87,105],"developed":[88],"an":[89,208],"intensive":[90],"intra-arterial":[93,182],"lidocaine":[94,183],"post-procedure":[96],"supportive":[97,125,210],"therapy":[98,211],"to":[99,123,174,212],"reduce":[100,213],"acute":[101],"toxic":[102],"effects":[103],"RESULTS:":[104],"observed":[106],"high":[108],"response":[109],"rate":[110],"(80%),":[111],"reduction":[113],"lesional":[115],"contrast":[116],"enhancement":[117],"all":[119],"responding":[120],"patients.":[121],"Due":[122],"treatment,":[126],"was":[128,150],"well":[129],"tolerated":[130],"median":[136],"duration":[137],"hospitalization":[139],"3":[141],"days":[142],"(range":[143],"1-10).":[144],"The":[145],"important":[147],"adverse":[148],"event":[149],"abdominal":[151],"pain.":[152],"Supportive":[153],"antibiotic":[156],"antiemetic":[158],"prophylaxis,":[159],"intravenous":[161],"hydratation":[162],"strictly":[164],"necessary":[165],"until":[166],"stabilization":[167],"serum":[169],"levels":[170],"transaminases":[172],"prevent":[175],"infections.":[176],"Major":[177],"analgesic":[178],"morphine":[180],"must":[184],"used":[186],"before":[187],"procedure.":[189],"CONCLUSIONS:":[190],"Our":[191],"results":[192],"suggest":[193],"that":[194],"using":[196],"DEBIRI":[197],"feasible":[198],"pretreated":[200],"CRC":[206],"adopting":[207],"adequate":[209],"side":[214],"effects.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}