{"id":"https://openalex.org/W10740491","doi":"https://doi.org/10.1093/ajcp/67.5.489","title":"Reliability of the Microdilution Technic for Detection of Methicillin-resistant Strains ofStaphylococcus aureus","display_name":"Reliability of the Microdilution Technic for Detection of Methicillin-resistant Strains ofStaphylococcus aureus","publication_year":1977,"publication_date":"1977-05-01","ids":{"openalex":"https://openalex.org/W10740491","doi":"https://doi.org/10.1093/ajcp/67.5.489","mag":"10740491","pmid":"https://pubmed.ncbi.nlm.nih.gov/324263"},"language":"en","primary_location":{"id":"doi:10.1093/ajcp/67.5.489","doi":"https://doi.org/10.1093/ajcp/67.5.489","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/67.5.489","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113777507","display_name":"Arthur L. Barry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur L. Barry","raw_affiliation_strings":["Section of Infectious and Immunologic Diseases, Department of Internal Medicine, University of California School of Medicine, Davis, California, and Clinical Microbiology Laboratory, University of California Davis\u2013Sacramento Medical Center, Sacramento, California","University of California, Davis, Davis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infectious and Immunologic Diseases, Department of Internal Medicine, University of California School of Medicine, Davis, California, and Clinical Microbiology Laboratory, University of California Davis\u2013Sacramento Medical Center, Sacramento, California","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California, Davis, Davis, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046750212","display_name":"Robert E. Badal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Badal","raw_affiliation_strings":["University of California, Davis, Davis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Davis, Davis, United States","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":1.9832,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.84824816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"5","first_page":"489","last_page":"495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.996999979019165},{"id":"https://openalex.org/keywords/heteroresistance","display_name":"heteroresistance","score":0.7540000081062317},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility-testing","display_name":"antimicrobial susceptibility testing","score":0.9020000100135803},{"id":"https://openalex.org/keywords/microdilution","display_name":"microdilution","score":0.8629999756813049},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8939999938011169},{"id":"https://openalex.org/keywords/oxacillin","display_name":"oxacillin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nafcillin","display_name":"nafcillin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cephalothin","display_name":"cephalothin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.5130000114440918},{"id":"https://openalex.org/keywords/disk-diffusion","display_name":"disk diffusion","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.8842103481292725},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7266226410865784},{"id":"https://openalex.org/C2780515650","wikidata":"https://www.wikidata.org/wiki/Q1638852","display_name":"Nafcillin","level":4,"score":0.6927655935287476},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.667401909828186},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.5876286029815674},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.5507975220680237},{"id":"https://openalex.org/C2776540679","wikidata":"https://www.wikidata.org/wiki/Q409262","display_name":"Meticillin","level":5,"score":0.4268714487552643},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3815251290798187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37674832344055176},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3639748990535736},{"id":"https://openalex.org/C2775965595","wikidata":"https://www.wikidata.org/wiki/Q1365581","display_name":"Micrococcaceae","level":4,"score":0.354829877614975},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.348410427570343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26138579845428467},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16118505597114563},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.14342465996742249},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D007201","descriptor_name":"Indicator Dilution Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009254","descriptor_name":"Nafcillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010068","descriptor_name":"Oxacillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010403","descriptor_name":"Penicillin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010405","descriptor_name":"Penicillinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajcp/67.5.489","doi":"https://doi.org/10.1093/ajcp/67.5.489","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/67.5.489","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:324263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/324263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1915621208","https://openalex.org/W1924349125","https://openalex.org/W1984986033","https://openalex.org/W2021343920","https://openalex.org/W2038788169","https://openalex.org/W2044761912","https://openalex.org/W2094217997","https://openalex.org/W2112397185","https://openalex.org/W2134503457","https://openalex.org/W2136931384","https://openalex.org/W2322253435","https://openalex.org/W2324854471","https://openalex.org/W2397140563","https://openalex.org/W2427995287","https://openalex.org/W2471307149"],"related_works":["https://openalex.org/W1793890708","https://openalex.org/W2121665796","https://openalex.org/W2153134686","https://openalex.org/W1586072435","https://openalex.org/W2032121597","https://openalex.org/W1982393316","https://openalex.org/W2157065794","https://openalex.org/W1503577122","https://openalex.org/W1638179291","https://openalex.org/W2092534061"],"abstract_inverted_index":{"To":[0],"determine":[1],"whether":[2],"the":[3,12,79,96,110,115,120,130,142,146,191,195,205,220,228],"microdilution":[4,132,179,221],"technic":[5],"for":[6,197],"antimicrobic":[7],"susceptibility":[8],"testing":[9],"could":[10],"detect":[11],"hetero-resistance":[13],"of":[14,66,90,112,122,129,145,200,207,217],"\"methicillin\"-resistant":[15],"Staphylococcus":[16],"aureus,":[17],"100":[18],"stock":[19],"cultures":[20],"(54":[21],"methicillin-susceptible":[22,192],"and":[23,32,41,61,83,125],"46":[24],"methicillin-resistant)":[25],"were":[26,53,81,99,184,190,202],"tested":[27],"against":[28],"methicillin,":[29,123],"oxacillin,":[30,124],"nafcillin":[31,126,135],"cephalothin.":[33,163],"Each":[34],"drug":[35],"was":[36,73,93],"diluted":[37,100],"in":[38,42,75,101],"Mueller-Hinton":[39,43,76],"broth":[40,44,77,102,116],"with":[45,152,223],"5%":[46,104],"NaCl.":[47,105],"Minimum":[48],"inhibitory":[49],"concentration":[50],"(MIC)":[51],"determinations":[52],"made":[54],"after":[55,63,85],"20-24":[56],"hours":[57,65],"at":[58],"35":[59],"C":[60],"again":[62],"48":[64,86],"incubation.":[67],"With":[68,178],"one":[69],"exception,":[70],"methicillin":[71,91],"resistance":[72,92],"detected":[74],"when":[78,95],"trays":[80],"reincubated":[82],"read":[84],"hours.":[87],"Earlier":[88],"detection":[89],"possible":[94],"penicillinase-stable":[97,147],"penicillins":[98],"containing":[103],"Further":[106],"studies":[107],"suggest":[108],"that":[109,156,170,209],"addition":[111,216],"NaCl":[113,218],"to":[114,140,162,168,187,219],"medium":[117],"might":[118,175],"improve":[119],"stabilities":[121],"during":[127,213],"storage":[128],"frozen":[131],"trays.":[133],"Either":[134],"or":[136],"oxacillin":[137],"would":[138],"appear":[139],"be":[141,176,211],"best":[143],"representative":[144],"penicillins.":[148],"Standardized":[149],"disk-diffusion":[150],"tests":[151,222],"cephalothin":[153,188,224],"disks":[154],"indicated":[155],"most":[157,181],"methicillin-resistant":[158,182],"strains":[159],"are":[160],"susceptible":[161],"However,":[164],"there":[165],"is":[166],"reason":[167],"believe":[169],"such":[171],"in-vitro":[172],"test":[173,229],"results":[174,230],"inappropriate.":[177],"tests,":[180],"isolates":[183],"more":[185],"resistant":[186],"than":[189],"strains,":[193],"but":[194],"MIC's":[196],"both":[198],"types":[199],"staphylococci":[201],"generally":[203],"within":[204],"range":[206],"concentrations":[208],"can":[210],"obtained":[212],"therapy.":[214],"The":[215],"did":[225],"not":[226],"alter":[227],"significantly.":[231]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}