{"id":"https://openalex.org/W107327640","doi":null,"title":"[Combined therapy with quinapril, an ACE inhibitor, and valsartan, a type 1 angiotensin II receptors blocker, for moderate chronic cardiac failure may raise the degree of neurohormonal block and improve 24-h heart rate variability compared to the effect of monotherapy (data from the trial SADKO-CHF)].","display_name":"[Combined therapy with quinapril, an ACE inhibitor, and valsartan, a type 1 angiotensin II receptors blocker, for moderate chronic cardiac failure may raise the degree of neurohormonal block and improve 24-h heart rate variability compared to the effect of monotherapy (data from the trial SADKO-CHF)].","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W107327640","mag":"107327640","pmid":"https://pubmed.ncbi.nlm.nih.gov/16206603"},"language":"ru","primary_location":{"id":"pmid:16206603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16206603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049468168","display_name":"A. A. Skvortsov","orcid":"https://orcid.org/0000-0003-2712-927X","observed_orcids":["https://orcid.org/0000-0003-2712-927X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A A Skvortsov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014226243","display_name":"\u041d\u0430\u0441\u043e\u043d\u043e\u0432\u0430 \u0421\u0432\u0435\u0442\u043b\u0430\u043d\u0430 \u041d\u0438\u043a\u043e\u043b\u0430\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-0920-7417","observed_orcids":["https://orcid.org/0000-0002-0920-7417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S N Nasonova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103274046","display_name":"A V Sychev","orcid":"https://orcid.org/0000-0001-7792-738X","observed_orcids":["https://orcid.org/0000-0001-7792-738X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A V Sychev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090703736","display_name":"G ARBOLISHVILI","orcid":"https://orcid.org/0000-0002-2252-3975","observed_orcids":["https://orcid.org/0000-0002-2252-3975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G N Arbolishvili","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039874572","display_name":"N BAKLANOVA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A Baklanova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"V Iu Mareev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Iu Mareev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111403831","display_name":"\u042e \u041d \u0411\u0435\u043b\u0435\u043d\u043a\u043e\u0432","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iu N Belenkov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2163,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.6082737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"77","issue":"8","first_page":"34","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.9480000138282776},{"id":"https://openalex.org/keywords/quinapril","display_name":"quinapril","score":0.9520000219345093},{"id":"https://openalex.org/keywords/valsartan","display_name":"valsartan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.718999981880188},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9599999785423279},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/neurohormonal-blockade","display_name":"neurohormonal blockade","score":0.7630000114440918},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.9350000023841858},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9120000004768372},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.9829999804496765},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8100000023841858},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.949999988079071},{"id":"https://openalex.org/keywords/hypertensive-heart-failure","display_name":"hypertensive heart failure","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2776992270","wikidata":"https://www.wikidata.org/wiki/Q596022","display_name":"Quinapril","level":5,"score":0.9820197820663452},{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.9288095235824585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8994399309158325},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6126742959022522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6107972264289856},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.5546212196350098},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5410751700401306},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46907585859298706},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.43826180696487427},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.43466541171073914},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4214743971824646},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.40406185388565063},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29230326414108276},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.08024254441261292}],"mesh":[{"descriptor_ui":"D000068756","descriptor_name":"Valsartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077583","descriptor_name":"Quinapril","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015716","descriptor_name":"Electrocardiography, Ambulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16206603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16206603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"Clinical Trial"},{"id":"mag:107327640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16206603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409459877","https://openalex.org/W1992894249","https://openalex.org/W1494670325","https://openalex.org/W1780997521","https://openalex.org/W2599780505","https://openalex.org/W1964540813","https://openalex.org/W2219266652","https://openalex.org/W2028089244","https://openalex.org/W2384756051","https://openalex.org/W2464238391"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"compare":[2],"effects":[3],"of":[4,7,33,56,104,112,129,185,206,262,267,282,291,320,339,357,360,365,372,378,388],"various":[5],"regimens":[6],"long-term":[8,373],"monotherapy":[9],"with":[10,27,44,59,127,327,333,383,390],"quinapril":[11,312,348,389],"(an":[12],"ACE":[13],"inhibitor)":[14],"and":[15,24,36,72,125,131,138,162,169,214,248,254,272,297,311,323,363],"valsartan":[16,310,314,334],"(a":[17],"type":[18],"1":[19,83,153,278],"angiotensin":[20,107],"II":[21,108,187,247],"receptors":[22],"blocker)":[23],"combined":[25],"therapy":[26,332],"these":[28],"drugs":[29],"on":[30],"the":[31,143,240,289,292,299,355,376],"activity":[32,111,208,319,377],"heurohormonal":[34],"systems":[35],"24-h":[37,268],"heart":[38,66,75,132],"rate":[39,133],"variability":[40],"(HRV)":[41],"in":[42,151,183,194,217,238,245,276,316,325,341,381],"patients":[43,58,84,326,346,382],"stable":[45,329],"moderate":[46,328,342,384],"chronic":[47],"cardiac":[48],"failure":[49],"(CCF).":[50],"MATERIAL":[51],"AND":[52],"METHODS:":[53],"A":[54,176,366],"total":[55],"80":[57],"FC":[60],"II-III":[61],"CCF":[62,345,385],"secondary":[63],"to":[64,156,166,172,199,211,222,233,252,256,288,318],"coronary":[65],"disease":[67],"(CHD),":[68],"delated":[69],"cardiomyopathy":[70],"(DCMP)":[71],"decompensated":[73],"hypertensive":[74],"(49%/47%/4%)":[76],"were":[77,123,274,301],"randomized":[78],"into":[79],"3":[80,96,163,280,298],"groups.":[81],"Group":[82],"(n":[85,92,97],"=":[86,93,98],"28)":[87],"received":[88],"quinapril,":[89],"group":[90,95,152,195,226,277],"2":[91,161,227,296],"26)--valsartan,":[94],"26)--quinapril":[99],"+":[100,313],"valsartan.":[101,391],"The":[102,369],"levels":[103],"norepinephrine":[105],"(NE),":[106],"(AT":[109],"II),":[110],"plasmic":[113,118],"renin":[114],"(PR),":[115],"aldosteron":[116],"(AS),":[117],"cerebral":[119],"sodiumuretic":[120],"peptide":[121],"(CSUP)":[122],"measured":[124],"ECG":[126],"determination":[128],"HRV":[130,269,324,340],"disturbances":[134],"was":[135],"made":[136],"before":[137],"3,":[139],"6":[140,260],"months":[141,261,281],"after":[142,259,279],"treatment.":[144,283,293],"RESULTS:":[145],"NE":[146],"concentration":[147],"lowered":[148],"most":[149],"significantly":[150,243],"(from":[154,164,197,231,250],"630":[155],"405":[157],"pg/ml)":[158,201],"vs":[159],"groups":[160,246,295],"525":[165,171],"490":[167],"pg/ml":[168,258],"from":[170,209,220],"480":[173],"pg/ml,":[174],"respectively).":[175,264],"6-month":[177],"treatment":[178],"induced":[179],"significant":[180],"changes":[181,266,285,300],"neither":[182],"concentrations":[184,191],"AT":[186],"nor":[188],"AC.":[189],"ATII":[190],"rose":[192],"2-fold":[193],"III":[196,249],"11.9":[198],"24.3":[200],"under":[202],"a":[203,215,350],"parallel":[204],"rise":[205],"PR":[207],"0.7":[210],"2.5":[212],"ng/ml/h":[213],"fall":[216],"AS":[218,228,361],"level":[219],"132":[221],"83":[223],"pg/ml.":[224],"In":[225,294],"diminished":[229],"also":[230],"165":[232],"126":[234],"pg/ml).":[235],"CSUP":[236],"decreased":[237],"all":[239],"groups,":[241],"but":[242],"only":[244],"350":[251],"237":[253],"322":[255],"204":[257],"treatment,":[263],"Significant":[265],"(both":[270],"spectral":[271],"temporary)":[273],"observed":[275],"These":[284],"lost":[286],"significance":[287],"end":[290],"less":[302],"pronounced.":[303],"CONCLUSION:":[304],"Quinapril":[305],"is":[306,386],"more":[307],"potent":[308],"than":[309],"combination":[315,387],"relation":[317],"sympathico-adrenal":[321],"system":[322,380],"CCF.":[330,343],"Long-term":[331],"does":[335],"not":[336],"improve":[337],"parameters":[338],"If":[344],"take":[347],"for":[349],"long":[351],"time,":[352],"they":[353],"develop":[354],"effect":[356],"disappearing":[358],"block":[359],"synthesis":[362],"reactivation":[364],"TII":[367],"production.":[368],"best":[370],"mechanism":[371],"control":[374],"over":[375],"renin-angiotensin-aldosteron":[379]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}