{"id":"https://openalex.org/W107257646","doi":null,"title":"Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea.","display_name":"Low dose flutamide in the treatment of acne vulgaris in women with or without oligomenorrhea or amenorrhea.","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W107257646","mag":"107257646","pmid":"https://pubmed.ncbi.nlm.nih.gov/10584414"},"language":"en","primary_location":{"id":"pmid:10584414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10584414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Changgeng yi xue za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103636596","display_name":"H.-S. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"H S Wang","raw_affiliation_strings":["Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T H Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T H Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113678330","display_name":"Y K Soong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y K Soong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0408,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.73934426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"22","issue":"3","first_page":"423","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flutamide","display_name":"flutamide","score":0.9129999876022339},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.9890000224113464},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.6399999856948853},{"id":"https://openalex.org/keywords/oligomenorrhea","display_name":"oligomenorrhea","score":0.9929999709129333},{"id":"https://openalex.org/keywords/amenorrhea","display_name":"amenorrhea","score":1.0},{"id":"https://openalex.org/keywords/antiandrogen-therapy","display_name":"antiandrogen therapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/5alpha-reductase-inhibition","display_name":"5\u03b1-reductase inhibition","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.8289999961853027},{"id":"https://openalex.org/keywords/serum-androgens","display_name":"serum androgens","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/estrogen-progestin-combination","display_name":"estrogen-progestin combination","score":0.6660000085830688},{"id":"https://openalex.org/keywords/inflammatory-acne-lesions","display_name":"inflammatory acne lesions","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8648580312728882},{"id":"https://openalex.org/C2778313021","wikidata":"https://www.wikidata.org/wiki/Q418669","display_name":"Flutamide","level":5,"score":0.8297246694564819},{"id":"https://openalex.org/C2776371013","wikidata":"https://www.wikidata.org/wiki/Q1620594","display_name":"hirsutism","level":5,"score":0.8120517134666443},{"id":"https://openalex.org/C2780186808","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Hyperandrogenism","level":5,"score":0.7851570844650269},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.753002405166626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6870635151863098},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6631550788879395},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.6599828004837036},{"id":"https://openalex.org/C2780572241","wikidata":"https://www.wikidata.org/wiki/Q45071","display_name":"Progestogen","level":3,"score":0.644086480140686},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.634826123714447},{"id":"https://openalex.org/C2778058571","wikidata":"https://www.wikidata.org/wiki/Q334655","display_name":"Amenorrhea","level":3,"score":0.443945050239563},{"id":"https://openalex.org/C2780657110","wikidata":"https://www.wikidata.org/wiki/Q2505402","display_name":"Dehydroepiandrosterone sulfate","level":4,"score":0.4388481378555298},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4116842746734619},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.3565250039100647},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3542323708534241},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.27284136414527893},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.15175455808639526},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.15125268697738647},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.09390920400619507},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08308342099189758},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000568","descriptor_name":"Amenorrhea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000568","descriptor_name":"Amenorrhea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000568","descriptor_name":"Amenorrhea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005485","descriptor_name":"Flutamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005485","descriptor_name":"Flutamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005485","descriptor_name":"Flutamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009839","descriptor_name":"Oligomenorrhea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009839","descriptor_name":"Oligomenorrhea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009839","descriptor_name":"Oligomenorrhea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011372","descriptor_name":"Progestins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011372","descriptor_name":"Progestins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011372","descriptor_name":"Progestins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10584414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10584414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Changgeng yi xue za zhi","raw_type":"Journal Article"},{"id":"mag:107257646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10584414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007183558","https://openalex.org/W2063009554","https://openalex.org/W2368309269","https://openalex.org/W2094630696","https://openalex.org/W2084782563","https://openalex.org/W2128828445","https://openalex.org/W1992141591","https://openalex.org/W2167192754","https://openalex.org/W2141444020","https://openalex.org/W107257646"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,95,102,113,207],"the":[2,4,12,20,105,122,130,238,262,277,291],"skin,":[3],"expression":[5],"of":[6,14,27,124,132,137,143,156,162,178,212,240,249,265,293],"androgen":[7],"action":[8],"is":[9,259],"dependent":[10],"on":[11,279],"reduction":[13],"testosterone":[15,164],"to":[16,90],"dihydrotestosterone":[17],"mediated":[18],"by":[19,216,282,290],"enzyme":[21],"5":[22],"alpha-reductase.":[23],"Additionally,":[24],"an":[25,191],"exaggeration":[26],"this":[28,50],"peripheral":[29],"metabolism":[30],"has":[31],"been":[32],"associated":[33],"with":[34,41,54,62,84,109,255,270],"acne":[35,42,76,213,266],"in":[36,49,92,121,151,185,193,204,221,232,237,253,268],"women.":[37],"METHODS:":[38],"Fifty-two":[39],"women":[40,74,106,239,269],"vulgaris":[43,267],"but":[44],"without":[45,75,219,257,272],"hirsutism":[46],"were":[47,77,107,196],"recruited":[48],"study,":[51],"including":[52,159],"42":[53],"oligomenorrhea":[55,273],"or":[56,256,271,274,285],"amenorrhea":[57],"(Group":[58,66,80],"1)":[59],"and":[60,116,134,139,168,188,190,199,227],"10":[61],"regular":[63],"menstrual":[64],"cycles":[65],"2).":[67],"As":[68],"a":[69,118,175],"control,":[70],"another":[71],"15":[72],"oligomenorrheic":[73],"also":[78],"studied":[79],"3).":[81],"Flutamide":[82],"combined":[83],"sequential":[85,110],"estrogen-progestogen":[86,258],"preparations":[87],"was":[88,100,127,214,235],"given":[89],"patients":[91,150],"Group":[93,96,103,152,205,208,241],"1.":[94,206],"2,":[97,117,209],"flutamide":[98,217,250],"alone":[99,218],"administered.":[101],"3,":[104],"treated":[108],"estrogen-progestogen.":[111],"RESULTS:":[112],"Groups":[114],"1":[115,153],"significant":[119],"decrease":[120,184],"number":[123],"inflammatory":[125],"lesions":[126],"found":[128,197],"at":[129],"end":[131],"3":[133,198,242],"6":[135,146,200],"months":[136,201],"treatment,":[138,149],"even":[140],"after":[141,202,243],"discontinuation":[142],"therapy":[144],"for":[145,261],"months.":[147],"Before":[148],"showed":[154],"signs":[155],"biochemical":[157],"hyperandrogenism,":[158],"elevated":[160],"levels":[161],"serum":[163,194,233,294],"(T),":[165],"androstenedione":[166],"(A),":[167],"dehydroepiandrosterone":[169],"sulfate":[170],"(DHEA-S),":[171],"as":[172,174],"well":[173],"decreased":[176],"level":[177],"sex":[179],"hormone-binding":[180],"globulin":[181],"(SHBG).":[182],"A":[183,246],"circulating":[186,222],"T":[187],"A,":[189,226],"elevation":[192],"SHBG":[195],"treatment":[203],"clinical":[210,263],"improvement":[211,264],"achieved":[215],"alteration":[220],"androgens":[223,234],"(including":[224],"T,":[225],"DHEA-S).":[228],"Similarly,":[229],"no":[230],"change":[231],"observed":[236],"treatment.":[244],"CONCLUSION:":[245],"low":[247],"dose":[248],"(250":[251],"mg/day)":[252],"association":[254],"effective":[260],"amenorrhea.":[275],"However,":[276],"effectiveness":[278],"hyperandrogenic":[280],"symptoms":[281],"antiandrogens":[283],"may":[284,286],"not":[287],"be":[288],"reflected":[289],"suppression":[292],"androgens.":[295]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}