{"id":"https://openalex.org/W107143237","doi":null,"title":"Patent Foramen Ovale (PFO) and cryptogenic stroke or transient ischemic attack: a follow-up study","display_name":"Patent Foramen Ovale (PFO) and cryptogenic stroke or transient ischemic attack: a follow-up study","publication_year":2014,"publication_date":"2014-11-24","ids":{"openalex":"https://openalex.org/W107143237","mag":"107143237"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/36904","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/36904","pdf_url":"http://hdl.handle.net/2077/36904","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/36904","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084649071","display_name":"Naqibullah Mirzada","orcid":"https://orcid.org/0000-0002-4808-8289","observed_orcids":["https://orcid.org/0000-0002-4808-8289"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Naqibullah Mirzada","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4808-8289","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084649071"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/patent-foramen-ovale","display_name":"patent foramen ovale","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cryptogenic-stroke","display_name":"cryptogenic stroke","score":0.921999990940094},{"id":"https://openalex.org/keywords/transient-ischemic-attack","display_name":"transient ischemic attack","score":0.9879999756813049},{"id":"https://openalex.org/keywords/patent-foramen-ovale-closure","display_name":"PFO closure","score":0.9449999928474426},{"id":"https://openalex.org/keywords/percutaneous-pfo-closure","display_name":"percutaneous PFO closure","score":0.8299999833106995},{"id":"https://openalex.org/keywords/paradoxical-embolism","display_name":"paradoxical embolism","score":0.9309999942779541},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.5799999833106995},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.8669999837875366},{"id":"https://openalex.org/keywords/sf-36","display_name":"SF-36","score":0.8920000195503235},{"id":"https://openalex.org/keywords/long-term-clinical-outcomes","display_name":"long-term clinical outcomes","score":0.7149999737739563},{"id":"https://openalex.org/keywords/device-related-complications","display_name":"device complications","score":0.6200000047683716},{"id":"https://openalex.org/keywords/stroke-risk-stratification","display_name":"stroke risk stratification","score":0.39800000190734863},{"id":"https://openalex.org/keywords/device-embolization","display_name":"device embolization","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2776893843","wikidata":"https://www.wikidata.org/wiki/Q757749","display_name":"Patent foramen ovale","level":3,"score":0.9691538214683533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9022179841995239},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6305558681488037},{"id":"https://openalex.org/C146834321","wikidata":"https://www.wikidata.org/wiki/Q2979672","display_name":"Closure (psychology)","level":2,"score":0.5465790629386902},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4468909502029419},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.42736101150512695},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.41641953587532043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3660896420478821},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34434741735458374},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3221031129360199},{"id":"https://openalex.org/C2780813298","wikidata":"https://www.wikidata.org/wiki/Q2071287","display_name":"Percutaneous","level":2,"score":0.0708979070186615},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/36904","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/36904","pdf_url":"http://hdl.handle.net/2077/36904","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:107143237","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/36904/1/gupea_2077_36904_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/36904","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/36904","pdf_url":"http://hdl.handle.net/2077/36904","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309605","display_name":"V\u00e4stra G\u00f6talandsregionen","ror":"https://ror.org/00a4x6777"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320324618","display_name":"Svenska L\u00e4kares\u00e4llskapet","ror":"https://ror.org/016ks4x90"},{"id":"https://openalex.org/F4320335047","display_name":"Sahlgrenska Akademin","ror":"https://ror.org/01tm6cn81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W107143237.pdf","grobid_xml":"https://content.openalex.org/works/W107143237.grobid-xml"},"referenced_works_count":102,"referenced_works":["https://openalex.org/W78630724","https://openalex.org/W99295644","https://openalex.org/W139252319","https://openalex.org/W262146094","https://openalex.org/W1177894438","https://openalex.org/W1535936781","https://openalex.org/W1966212593","https://openalex.org/W1966972223","https://openalex.org/W1968693961","https://openalex.org/W1969661146","https://openalex.org/W1969959282","https://openalex.org/W1975186830","https://openalex.org/W1979350260","https://openalex.org/W1981681632","https://openalex.org/W1985477573","https://openalex.org/W1987594938","https://openalex.org/W1987659490","https://openalex.org/W1992389523","https://openalex.org/W1992510986","https://openalex.org/W1994445887","https://openalex.org/W1994580388","https://openalex.org/W1997599767","https://openalex.org/W2000314855","https://openalex.org/W2007285236","https://openalex.org/W2007470220","https://openalex.org/W2008016959","https://openalex.org/W2010050468","https://openalex.org/W2013876317","https://openalex.org/W2014955376","https://openalex.org/W2021556603","https://openalex.org/W2025064568","https://openalex.org/W2035445378","https://openalex.org/W2038084278","https://openalex.org/W2038749838","https://openalex.org/W2040262370","https://openalex.org/W2042086239","https://openalex.org/W2046904461","https://openalex.org/W2051198244","https://openalex.org/W2052016798","https://openalex.org/W2053081695","https://openalex.org/W2054213128","https://openalex.org/W2056068526","https://openalex.org/W2061835461","https://openalex.org/W2065603215","https://openalex.org/W2073211604","https://openalex.org/W2074127944","https://openalex.org/W2077122480","https://openalex.org/W2078103827","https://openalex.org/W2083958640","https://openalex.org/W2087491232","https://openalex.org/W2087860321","https://openalex.org/W2088339033","https://openalex.org/W2092140802","https://openalex.org/W2093814225","https://openalex.org/W2096629412","https://openalex.org/W2098159631","https://openalex.org/W2098512333","https://openalex.org/W2098649094","https://openalex.org/W2101535898","https://openalex.org/W2101552348","https://openalex.org/W2101620652","https://openalex.org/W2103291158","https://openalex.org/W2103945128","https://openalex.org/W2109848499","https://openalex.org/W2112500715","https://openalex.org/W2116228592","https://openalex.org/W2119731028","https://openalex.org/W2121041310","https://openalex.org/W2121187530","https://openalex.org/W2126631219","https://openalex.org/W2127402377","https://openalex.org/W2128616966","https://openalex.org/W2131986872","https://openalex.org/W2132241867","https://openalex.org/W2133714466","https://openalex.org/W2136709547","https://openalex.org/W2138595885","https://openalex.org/W2139741868","https://openalex.org/W2141842749","https://openalex.org/W2144597953","https://openalex.org/W2145054501","https://openalex.org/W2145426071","https://openalex.org/W2151720801","https://openalex.org/W2152445983","https://openalex.org/W2155477484","https://openalex.org/W2156263958","https://openalex.org/W2157489282","https://openalex.org/W2159608669","https://openalex.org/W2165462135","https://openalex.org/W2168439673","https://openalex.org/W2169197012","https://openalex.org/W2170443916","https://openalex.org/W2170982765","https://openalex.org/W2171369299","https://openalex.org/W2173724038","https://openalex.org/W2189726121","https://openalex.org/W2313084802","https://openalex.org/W2326526061","https://openalex.org/W2331626549","https://openalex.org/W2399029551","https://openalex.org/W2560549015","https://openalex.org/W3021852519"],"related_works":["https://openalex.org/W7127885510","https://openalex.org/W2742002176","https://openalex.org/W4386485253","https://openalex.org/W1853132177","https://openalex.org/W7131395995","https://openalex.org/W2890009232","https://openalex.org/W2909675546","https://openalex.org/W4411548716","https://openalex.org/W2055537201","https://openalex.org/W2745700789"],"abstract_inverted_index":{"Aims:":[0],"The":[1,56,73,100,125,290,311,362,509,564],"overall":[2],"aim":[3,58,75,102,127],"of":[4,16,28,33,66,97,108,133,191,244,287,306,341,375,439,474,482,498,515,542,567,587,603,642,658,666],"this":[5],"thesis":[6],"was":[7,59,76,103,128,161,246,282,293,315,327,367],"to":[8,60,77,91,104,129,139,145,205,319,489,501,518,524,559,610,635,653],"study":[9,78,166,190,223,240],"the":[10,180,192,227,249,271,359,430,434,447,459,464,490,520,572,576,585,601,611,655],"long-term":[11,63,106,164,346,485,555],"clinical":[12,64,221,598],"outcomes":[13,107,599],"in":[14,30,113,179,183,233,241,253,257,285,396,455,458,463,487,548],"terms":[15],"survival,":[17],"complications,":[18],"recurrent":[19,334,543,622],"stroke":[20,152,335,442,544,581,606,623],"or":[21,297,336,445,452,462,624,626],"transient":[22],"ischemic":[23,151],"attack":[24],"(TIA),":[25],"and":[26,40,143,150,174,195,214,224,260,266,415,443,504,523,527,545,553,582,584,607,648,661],"quality":[27,132,243,481,497,514,641,665],"life":[29,134,245,483,499,516,667],"a":[31,62,80,121,140,148,162,188,200,219,238,338,475,588,637],"group":[32,269,432,511,522],"patients":[34,52,67,93,114,146,170,198,228,255,302,331,355,395,494],"with":[35,51,147,199,263,372,429,538],"patent":[36],"foramen":[37],"ovale":[38],"(PFO)":[39],"cryptogenic":[41,580],"stroke.":[42],"Patients":[43,377],"who":[44,53,68,115,153,171,202],"had":[45,54,69,116,154],"undergone":[46,70,156],"PFO":[47,71,82,89,109,123,136,149,157,177,193,201,210,231,280,325,360,421,476,534,560,573,583,591,632,659],"closure":[48,90,110,137,178,211,281,326,366,380,414,422,473,493,521,535,561,592,633,660],"were":[49,203,349,356,381,399,411,418,562],"compared":[50,138,144,262,428,500,517,609],"not.":[55],"first":[57],"provide":[61,425,595],"follow-up":[65,165,222,291,313],"closure.":[72],"second":[74],"whether":[79],"multidisciplinary":[81,122,589],"conference":[83,574],"could":[84,615],"maintain":[85],"stringent":[86],"criteria":[87],"for":[88,209,365,379,413,433,446],"identify":[92],"at":[94,230,324,358,484,571],"high":[95],"risk":[96,541],"paradoxical":[98],"embolization.":[99],"third":[101],"compare":[105],"versus":[111],"non-closure":[112,431,491,510,612],"been":[117],"carefully":[118],"selected":[119],"by":[120],"conference.":[124],"fourth":[126],"assess":[130,654],"health-related":[131,480],"after":[135],"normal":[141],"population":[142,507,530],"not":[155,419,424,594],"closure.\\n\\nMethods:":[158],"Paper":[159,185,216,235,258,277,352,392,397,468],"I":[160,259],"retrospective":[163],"that":[167,471],"included":[168,256],"all":[169,197,226,254,394],"between":[172,212,579],"1997":[173],"2006":[175,213],"underwent":[176],"GUCH":[181,207],"center":[182,208],"Gothenburg.":[184],"II":[186,398],"is":[187,218,237,536,546],"descriptive":[189],"conferences":[194,232],"includes":[196,225],"referred":[204],"our":[206],"2009.":[215],"III":[217],"prospective":[220,239,645],"discussed":[229],"2006\u20132009.":[234],"IV":[236,469],"which":[242],"assessed":[247],"using":[248],"SF-36":[250,273],"Health":[251],"Survey":[252],"III,":[261,393],"an":[264,373,502,525],"age-":[265,503,526],"gender-matched":[267,505,528],"reference":[268],"from":[270,333],"Swedish":[272],"normative":[274,506,529],"database.\\n\\nResults:":[275],"In":[276,351,391],"I,":[278],"percutaneous":[279,631],"successfully":[283],"performed":[284],"85":[286],"86":[288],"patients.":[289,550],"rate":[292,340,364,566],"100%.":[294],"No":[295,345,551],"cardiovascular":[296],"cerebrovascular":[298],"deaths":[299],"occurred.":[300],"Two":[301,330],"(both":[303],"women)":[304],"died":[305],"lung":[307],"cancer":[308],"during":[309],"follow-up.":[310],"mean":[312],"time":[314],"7.3":[316],"years":[317,386,404],"(5":[318],"12.4":[320],"years).":[321],"Mean":[322],"age":[323,384],"49":[328],"years.":[329],"suffered":[332],"TIA,":[337],"recurrence":[339],"0.3%":[342],"per":[343],"year.":[344],"device-related":[347,556],"complications":[348,557],"observed.":[350,563],"II,":[353],"311":[354],"evaluated":[357],"conferences.":[361],"acceptance":[363,565],"similar":[368,496],"throughout":[369],"these":[370],"years,":[371,389],"average":[374],"46%.":[376],"accepted":[378,412],"younger":[382],"(mean":[383],"50":[385],"vs.":[387],"58":[388],"p<0.001).":[390],"followed":[400],"up":[401],"almost":[402],"five":[403],"later.":[405],"Of":[406],"314":[407],"patients,":[408],"151":[409],"(48%)":[410],"163":[416],"(52%)":[417],"accepted.":[420],"did":[423],"significant":[426,617],"benefit":[427,657],"primary":[435],"endpoint":[436],"(a":[437],"composite":[438,602],"all-cause":[440,453,604,628],"mortality,":[441,605],"TIA)":[444],"secondary":[448],"endpoints":[449],"(stroke,":[450],"TIA":[451,608,625],"mortality":[454,552],"isolation),":[456],"either":[457],"intention-to-treat":[460],"analysis":[461],"as-treated":[465],"analysis.":[466],"Finally,":[467],"demonstrated":[470,620],"device":[472],"provides":[477],"significantly":[478],"better":[479],"follow-up,":[486],"comparison":[488],"group;":[492],"reported":[495],"(p<0.05).":[508,531],"showed":[512],"poorer":[513],"both":[519],"\\n\\nConclusions:":[532],"Percutaneous":[533],"associated":[537],"very":[539],"low":[540],"feasible":[547],"most":[549],"no":[554],"related":[558],"less":[568],"than":[569],"50%":[570],"underscores":[575],"complex":[577],"relationship":[578],"importance":[586],"approach.":[590],"does":[593],"any":[596,616],"improved":[597],"regarding":[600,621,627],"group.":[613],"Neither":[614],"differences":[618],"be":[619],"mortality.":[629],"However,":[630],"appears":[634],"have":[636],"favorable":[638],"impact":[639],"on":[640,664],"life.":[643],"Larger":[644],"observational":[646],"studies":[647,650],"randomized":[649],"are":[651],"necessary":[652],"real":[656],"its":[662],"influence":[663]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}