{"id":"https://openalex.org/W106950581","doi":null,"title":"Sodium nitroprusside: physiologic effects as a nitric oxide donor in three species.","display_name":"Sodium nitroprusside: physiologic effects as a nitric oxide donor in three species.","publication_year":1995,"publication_date":"1995-03-01","ids":{"openalex":"https://openalex.org/W106950581","mag":"106950581","pmid":"https://pubmed.ncbi.nlm.nih.gov/7670593"},"language":"en","primary_location":{"id":"pmid:7670593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7670593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of impotence research","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080326322","display_name":"Flavio Eduardo Trigo-Rocha","orcid":"https://orcid.org/0000-0003-4362-1715","observed_orcids":["https://orcid.org/0000-0003-4362-1715"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Trigo-Rocha","raw_affiliation_strings":["Department of Urology, University of California School of Medicine, San Francisco 94143-0738, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of California School of Medicine, San Francisco 94143-0738, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024761996","display_name":"Luis Mart\u00ednez\u2010Pi\u00f1eiro","orcid":"https://orcid.org/0000-0001-9063-1663","observed_orcids":["https://orcid.org/0000-0001-9063-1663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Martinez-Pi\u00f1eiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108410160","display_name":"Craig F. Donatucci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C F Donatucci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066973570","display_name":"Geng\u2010Long Hsu","orcid":"https://orcid.org/0000-0002-5383-2252","observed_orcids":["https://orcid.org/0000-0002-5383-2252"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G L Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081192418","display_name":"Tom F. Lue","orcid":"https://orcid.org/0000-0002-0499-9486","observed_orcids":["https://orcid.org/0000-0002-0499-9486","https://orcid.org/0009-0007-0884-8283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T F Lue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112773892","display_name":"Emil A. Tanagho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A Tanagho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3097,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.55454399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"49","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":1.0},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/penile-erection","display_name":"penile erection","score":0.9639999866485596},{"id":"https://openalex.org/keywords/intracavernosal-pressure","display_name":"intracavernous pressure","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cavernous-smooth-muscle-relaxation","display_name":"cavernous smooth muscle relaxation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.6079999804496765},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.7239999771118164},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5410000085830688},{"id":"https://openalex.org/keywords/cross-species-comparison","display_name":"cross-species comparison","score":0.7229999899864197},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monkeys","display_name":"monkeys","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.9785286784172058},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8379440307617188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7126865983009338},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.5483532547950745},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5457358956336975},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4680347740650177},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.43931955099105835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4383503198623657},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.434583842754364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39437589049339294},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3579874038696289},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16779303550720215},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008254","descriptor_name":"Macaca nemestrina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008254","descriptor_name":"Macaca nemestrina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008254","descriptor_name":"Macaca nemestrina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010410","descriptor_name":"Penile Erection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010410","descriptor_name":"Penile Erection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010410","descriptor_name":"Penile Erection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7670593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7670593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of impotence research","raw_type":"Comparative Study"},{"id":"mag:106950581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7670593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010948304","https://openalex.org/W2356705105","https://openalex.org/W38937298","https://openalex.org/W8525297","https://openalex.org/W2011083043","https://openalex.org/W2143726078","https://openalex.org/W95770330","https://openalex.org/W1994610861","https://openalex.org/W2019172501","https://openalex.org/W2253671572"],"abstract_inverted_index":{"Recent":[0],"in":[1,4,34,64,71,93,100,143,149,162,180,184,191,196,210,217,222,225],"vitro":[2],"and":[3,22,60,81,90,97,103,117,122,145,193,212],"vivo":[5],"studies":[6],"have":[7],"suggested":[8],"that":[9],"nitric":[10,40,233],"oxide":[11,41,234],"may":[12,228],"be":[13,230],"the":[14,35,49,75,115,202,237],"neurotransmitter":[15],"responsible":[16],"for":[17,114,120,236],"cavernous":[18,76],"smooth":[19],"muscle":[20],"relaxation":[21],"penile":[23,62],"erection.":[24],"Sodium":[25,67,205],"nitroprusside,":[26],"after":[27,151,170],"combining":[28],"with":[29,214],"different":[30],"kinds":[31],"of":[32,78,108,139,153,172,175,239],"thiols":[33],"cellular":[36],"cytoplasm,":[37],"can":[38],"effect":[39],"release.":[42],"We":[43],"undertook":[44],"this":[45],"study":[46],"to":[47,52,58,131,201],"determine":[48],"physiologic":[50],"response":[51,130],"sodium":[53,132,176],"nitroprusside":[54,68,133,206],"injection":[55,134,152,171],"when":[56],"used":[57],"induce":[59],"maintain":[61],"erection":[63],"three":[65],"species.":[66],"was":[69,111,178,187],"injected":[70,84,110],"increasing":[72],"concentrations":[73],"into":[74],"tissue":[77],"rats,":[79],"dogs":[80,102,121,192,211],"monkeys.":[82,105,123],"Dosages":[83],"were":[85],"10(-4)":[86,96],"M,":[87],"10(-3)":[88,98,154],"M":[89,92,99,155,174],"10(-2)":[91,173],"10":[94],"rats;":[95],"five":[101,104],"The":[106,124,182],"volume":[107],"drug":[109],"0.05":[112],"ml":[113,119],"rats":[116,197,223],"0.5":[118],"results":[125],"show":[126],"a":[127,159],"dose-dependent":[128],"erectile":[129,241],"(mean":[135,165],"intracavernous":[136,163],"pressure":[137,164,186],"increase":[138,161,166],"102.4":[140],"cm":[141,147,168],"H2O":[142,148,169],"dogs,":[144],"98.4":[146],"monkeys":[150,213],"nitroprusside).":[156],"However,":[157,220],"only":[158],"slight":[160],"28.4":[167],"nitroprusside)":[177],"noted":[179],"rats.":[181],"drop":[183],"blood":[185,218],">":[188],"15":[189],"mmHg":[190],"monkeys,":[194],"while":[195],"it":[198],"varied":[199],"according":[200],"dose":[203],"studied.":[204],"induced":[207],"excellent":[208],"erections":[209],"minimal":[215],"alteration":[216],"pressure.":[219],"administration":[221],"resulted":[224],"hypotension.":[226],"Nitroprusside":[227],"not":[229],"an":[231],"acceptable":[232],"donor":[235],"treatment":[238],"male":[240],"dysfunction.":[242]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}