{"id":"https://openalex.org/W106818324","doi":"https://doi.org/10.4049/jimmunol.182.supp.40.26","title":"Activation of anti-tumor NK cells by gamma delta T lymphocytes through 4-1BB engagement (40.26)","display_name":"Activation of anti-tumor NK cells by gamma delta T lymphocytes through 4-1BB engagement (40.26)","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W106818324","doi":"https://doi.org/10.4049/jimmunol.182.supp.40.26","mag":"106818324"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.182.supp.40.26","doi":"https://doi.org/10.4049/jimmunol.182.supp.40.26","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.40.26","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001572155","display_name":"Andrei I. Chapoval","orcid":"https://orcid.org/0000-0002-3426-1036","observed_orcids":["https://orcid.org/0000-0002-3426-1036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrei Chapoval","raw_affiliation_strings":["Otorhinolaryngology-Head and Neck Surgery","1Otorhinolaryngology-Head and Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]},{"raw_affiliation_string":"1Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109117767","display_name":"Amudhan Maniar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amudhan Maniar","raw_affiliation_strings":["Otorhinolaryngology-Head and Neck Surgery","1Otorhinolaryngology-Head and Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]},{"raw_affiliation_string":"1Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419418","display_name":"Xiaoyu Zhang","orcid":"https://orcid.org/0000-0002-7566-3445","observed_orcids":["https://orcid.org/0000-0002-7566-3445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyu Zhang","raw_affiliation_strings":["Otorhinolaryngology-Head and Neck Surgery","1Otorhinolaryngology-Head and Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]},{"raw_affiliation_string":"1Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087859996","display_name":"Brian Gastman","orcid":"https://orcid.org/0000-0003-2691-3409","observed_orcids":["https://orcid.org/0000-0003-2691-3409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian R Gastman","raw_affiliation_strings":["Otorhinolaryngology-Head and Neck Surgery","1Otorhinolaryngology-Head and Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]},{"raw_affiliation_string":"1Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060929582","display_name":"C. David Pauza","orcid":"https://orcid.org/0000-0002-0559-793X","observed_orcids":["https://orcid.org/0000-0002-0559-793X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. David Pauza","raw_affiliation_strings":["Institute of Human Virology, University of Maryland , Baltimore, MD","2Institute of Human Virology, University of Maryland, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, University of Maryland , Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"2Institute of Human Virology, University of Maryland, Baltimore, MD","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028801725","display_name":"Scott Eric Strome","orcid":"https://orcid.org/0000-0003-0927-8722","observed_orcids":["https://orcid.org/0000-0003-0927-8722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott E Strome","raw_affiliation_strings":["Otorhinolaryngology-Head and Neck Surgery","1Otorhinolaryngology-Head and Neck Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]},{"raw_affiliation_string":"1Otorhinolaryngology-Head and Neck Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"182","issue":"Supplement_1","first_page":"40.26","last_page":"40.26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.9430000185966492},{"id":"https://openalex.org/keywords/4-1bbl","display_name":"4-1BBL","score":0.9729999899864197},{"id":"https://openalex.org/keywords/isopentenyl-pyrophosphate","display_name":"isopentenyl pyrophosphate","score":0.9350000023841858},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.8339999914169312},{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.7549999952316284},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cd69","display_name":"CD69","score":0.9990000128746033},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/innate-adaptive-immune-bridge","display_name":"innate-adaptive immune bridge","score":0.6970000267028809},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.6963313221931458},{"id":"https://openalex.org/C2778867473","wikidata":"https://www.wikidata.org/wiki/Q17544382","display_name":"NKG2D","level":4,"score":0.6856530904769897},{"id":"https://openalex.org/C183315844","wikidata":"https://www.wikidata.org/wiki/Q6155969","display_name":"Janus kinase 3","level":5,"score":0.6201189756393433},{"id":"https://openalex.org/C182676581","wikidata":"https://www.wikidata.org/wiki/Q4201948","display_name":"CD49b","level":5,"score":0.5658585429191589},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.509222149848938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5004053115844727},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.4825369715690613},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4445047378540039},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.44420546293258667},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43993908166885376},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4059106707572937},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3424416184425354},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3348774313926697},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08639517426490784},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.182.supp.40.26","doi":"https://doi.org/10.4049/jimmunol.182.supp.40.26","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.40.26","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2046829925","https://openalex.org/W2161255002","https://openalex.org/W4311539112","https://openalex.org/W2040677394","https://openalex.org/W1549959029","https://openalex.org/W2167719370","https://openalex.org/W2075064734","https://openalex.org/W2017791892","https://openalex.org/W7131788544","https://openalex.org/W2378807397"],"abstract_inverted_index":{"Abstract":[0],"Emerging":[1],"evidence":[2],"suggests":[3],"that":[4,35,84,120,173,206],"gamma":[5],"delta":[6],"(\u03b3d)":[7],"T":[8,41,94,116,167,179,208],"cells":[9,54,91,122,134,175,197,216],"play":[10],"a":[11,101],"critical":[12],"role":[13],"in":[14,201],"bridging":[15],"innate":[16],"and":[17,59,65,77,118,148,150,184,222],"adaptive":[18],"immune":[19],"responses,":[20],"yet":[21],"the":[22,57,75,110,190],"mechanisms":[23],"responsible":[24],"for":[25],"these":[26,121,194],"effects":[27,192],"are":[28],"uncertain.":[29],"In":[30,169],"this":[31],"study":[32],"we":[33,99,171],"show":[34],"isopentenyl":[36],"pyrophosphate":[37],"(IPP)":[38],"activated":[39,114],"\u03b3d":[40],"lymphocytes":[42,95,180,209],"induce":[43,210],"cytolytic":[44,191],"function":[45],"of":[46,62,74,87,105,112,126,130,146,152,162,193,212,225],"Ig":[47,88,131,213],"stimulated":[48],"NK":[49,53,90,133,163,174,196,215],"cells.":[50],"These":[51],"\"costimulated\"":[52,195],"up":[55,144,181,223],"regulate":[56,182],"CD54":[58,147],"CD69":[60,149],"markers":[61],"cellular":[63],"activation":[64,161,211],"also":[66],"display":[67],"enhanced":[68],"cytotoxicity":[69],"against":[70,198],"squamous":[71],"cell":[72,227],"carcinoma":[73],"head":[76],"neck":[78],"(SCCHN).":[79],"Based":[80],"on":[81,109],"our":[82,203],"findings":[83],"\"co":[85],"stimulation\"":[86],"primed":[89,132,214],"by":[92,155],"\u03b3\u03b4":[93,115,166,207],"requires":[96],"cell-to-cell":[97],"contact,":[98],"performed":[100],"comprehensive":[102],"expression":[103],"analysis":[104],"TNFSF":[106],"members":[107],"expressed":[108],"surface":[111],"IPP":[113],"lymphocytes,":[117],"found":[119],"express":[123],"high":[124],"levels":[125],"4-1BB":[127,157,219],"ligand.":[128],"Stimulation":[129],"with":[135,165,177],"4-1BBL":[136],"but":[137],"not":[138],"mock":[139],"transfected":[140],"P815":[141],"cells,":[142],"induces":[143],"regulation":[145,224],"blockade":[151,187],"4-1BB/4-1BBL":[153],"interaction":[154],"soluble":[156],"fusion":[158],"protein":[159],"decreased":[160],"co-cultured":[164],"lymphocytes.":[168],"addition,":[170],"observed":[172],"cultured":[176],"Ig/\u03b3\u03b4":[178],"NKG2D":[183],"anti-NKG2D":[185],"mAb":[186],"partially":[188],"abrogates":[189],"SCCHN.":[199],"Taken":[200],"concert,":[202],"data":[204],"indicate":[205],"through":[217],"coordinated":[218],"-4-1BBL":[220],"interactions":[221],"targeted":[226],"death":[228],"pathways.":[229]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}