{"id":"https://openalex.org/W106795891","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.718.8","title":"Sub\u2010cellular zinc distribution: a novel role for lysosomal\u2010mediated cell death in malignant breast tumor cells","display_name":"Sub\u2010cellular zinc distribution: a novel role for lysosomal\u2010mediated cell death in malignant breast tumor cells","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W106795891","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.718.8","mag":"106795891"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.718.8","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.718.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.718.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060725632","display_name":"Ver\u00f3nica L\u00f3pez","orcid":"https://orcid.org/0000-0001-9432-3238","observed_orcids":["https://orcid.org/0000-0001-9432-3238"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Lopez","raw_affiliation_strings":["Nutritional Sciences Penn State University Park PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences Penn State University Park PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035144349","display_name":"Farnaz Foolad","orcid":"https://orcid.org/0000-0002-5348-2889","observed_orcids":["https://orcid.org/0000-0002-5348-2889"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farnaz Foolad","raw_affiliation_strings":["Nutritional Sciences Penn State University Park PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences Penn State University Park PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053198596","display_name":"Shannon L. Kelleher","orcid":"https://orcid.org/0000-0003-0613-6294","observed_orcids":["https://orcid.org/0000-0003-0613-6294"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon L. Kelleher","raw_affiliation_strings":["Nutritional Sciences Penn State University Park PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences Penn State University Park PA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0180526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.31369999051094055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-distribution","display_name":"zinc distribution","score":0.8199999928474426},{"id":"https://openalex.org/keywords/znt2","display_name":"ZnT2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/lysosomal-membrane-permeabilization","display_name":"lysosomal membrane permeabilization","score":0.8560000061988831},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9909999966621399},{"id":"https://openalex.org/keywords/caspase-independent-apoptosis","display_name":"caspase-independent apoptosis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lysosomal-swelling","display_name":"lysosomal swelling","score":0.7229999899864197},{"id":"https://openalex.org/keywords/lysosomal-enzymes","display_name":"lysosomal enzymes","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.7070202231407166},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6927558779716492},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5661002993583679},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5562882423400879},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5553445816040039},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5502753257751465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46449804306030273},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4183891713619232},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3778197467327118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2742372751235962},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2000138759613037},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09610947966575623}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.718.8","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.718.8","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.718.8","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W784185838","https://openalex.org/W2069451604","https://openalex.org/W2003336619","https://openalex.org/W1590813956","https://openalex.org/W3003042645","https://openalex.org/W2303530438","https://openalex.org/W3175192491","https://openalex.org/W2169527889","https://openalex.org/W2058964568","https://openalex.org/W4411957871"],"abstract_inverted_index":{"Numerous":[0,61],"studies":[1],"implicate":[2],"abnormally":[3],"high":[4],"zinc":[5],"(Zn)":[6],"levels":[7],"in":[8,17,36,44,93,123,144,157],"the":[9,23,77,158],"etiology":[10],"of":[11,26,73,80,120],"breast":[12,38,146],"cancer.":[13],"ZnT2":[14,33],"plays":[15],"role":[16],"Zn":[18,105,121,159],"sequestration,":[19],"protecting":[20],"cells":[21,100],"from":[22],"cytotoxic":[24,62],"effects":[25],"excess":[27],"Zn.":[28],"We":[29,96],"previously":[30],"determined":[31,97],"that":[32,50,98,118,131,155],"is":[34],"over\u2010expressed":[35],"malignant":[37,145],"tumor":[39,94,147],"cells.":[40,95,110,148],"Intriguingly,":[41],"ZnT2\u2010attenuation":[42,112,132],"resulted":[43,122],"caspase\u2010independent":[45],"apoptosis.":[46,60],"Emerging":[47],"evidence":[48],"suggests":[49],"lysosomal":[51,74,124,137],"rupture":[52],"releases":[53],"catabolic":[54],"enzymes":[55],"and":[56],"activates":[57],"or":[58],"potentiates":[59],"conditions,":[63],"such":[64],"as":[65,140],"reactive":[66],"oxygen":[67],"species":[68],"(ROS)":[69],"generation":[70],"induce":[71],"permeabilization":[72],"membranes.":[75],"Thus,":[76],"primary":[78],"objective":[79],"this":[81],"study":[82],"was":[83,88],"to":[84,168],"determine":[85],"if":[86],"ZnT2\u2010attentuation":[87],"associated":[89],"with":[90,108],"lysosome\u2010mediated":[91,162],"apoptosis":[92],"ZnT2\u2010attenuated":[99],"had":[101],"significantly":[102,113],"higher":[103],"cytoplasmic":[104],"level":[106],"compared":[107],"ZnT2\u2010expressing":[109],"Curiously,":[111],"increased":[114,133],"ROS":[115,134],"generation,":[116],"suggesting":[117,154],"re\u2010distribution":[119],"swelling.":[125],"Taken":[126],"together,":[127],"these":[128],"results":[129],"illustrated":[130],"potentially":[135],"revealing":[136],"membrane":[138],"instability":[139],"an":[141],"apoptotic":[142],"signal":[143],"Our":[149],"data":[150],"provide":[151],"novel":[152],"insight":[153],"changes":[156],"microenvironment":[160],"regulate":[161],"cell":[163],"death.":[164],"Supported":[165],"by":[166],"DOD\u2010BCRP":[167],"SLK.":[169]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}