{"id":"https://openalex.org/W106702402","doi":null,"title":"Can Sir(2) regulate cancer?","display_name":"Can Sir(2) regulate cancer?","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W106702402","mag":"106702402","pmid":"https://pubmed.ncbi.nlm.nih.gov/19750026","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2741025"},"language":"en","primary_location":{"id":"pmid:19750026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19750026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellscience","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2741025/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083950364","display_name":"Pratibha Vivek Nerurkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratibha V Nerurkar","raw_affiliation_strings":["Laboratory of Metabolic Disorders and Alternative Medicine, Dept. of Molecular Biosciences and Bioengineering (MBBE), CTAHR, , University of Hawaii, Honolulu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Metabolic Disorders and Alternative Medicine, Dept. of Molecular Biosciences and Bioengineering (MBBE), CTAHR, , University of Hawaii, Honolulu","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042130943","display_name":"Vivek R. Nerurkar","orcid":"https://orcid.org/0000-0002-2044-2784","observed_orcids":["https://orcid.org/0000-0002-2044-2784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vivek R Nerurkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"4","issue":"4","first_page":"50","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8169999718666077},{"id":"https://openalex.org/keywords/dbc1","display_name":"DBC1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.41600000858306885},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5630000233650208},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7879999876022339},{"id":"https://openalex.org/keywords/fragile-x-syndrome","display_name":"fragile X syndrome","score":0.8159999847412109},{"id":"https://openalex.org/keywords/gene-repression","display_name":"gene repression","score":0.6159999966621399},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.781000018119812},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9789999723434448},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5410000085830688},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.861912727355957},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.7366622686386108},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.6917434334754944},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.661554217338562},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.635269045829773},{"id":"https://openalex.org/C2776536020","wikidata":"https://www.wikidata.org/wiki/Q21113719","display_name":"Sirtuin 1","level":4,"score":0.6343426704406738},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5731896758079529},{"id":"https://openalex.org/C2777595374","wikidata":"https://www.wikidata.org/wiki/Q18040385","display_name":"SIRT6","level":5,"score":0.4822893440723419},{"id":"https://openalex.org/C199848840","wikidata":"https://www.wikidata.org/wiki/Q18036605","display_name":"SIRT2","level":5,"score":0.4662218391895294},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4445810317993164},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4273257851600647},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3904329538345337},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3537403345108032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33559197187423706},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25316527485847473},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22903603315353394},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22560769319534302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1716141402721405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16046082973480225},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.10045406222343445}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:19750026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19750026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2741025","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2741025/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cellscience","raw_type":"Text"},{"id":"mag:106702402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19750026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2741025","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2741025/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cellscience","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G147334744","display_name":"RCMI CLINICAL RESEARCH INFRASTRUCTURE INITIATIVE (RCRII)","funder_award_id":"5p20rr011091-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3355429260","display_name":"Bioscience Research Infrastructure Development for Grant Enhancement and Success","funder_award_id":"G12RR003061","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5542667993","display_name":"Longevity foods, SIRT activation and diabetic dyslipidemia.","funder_award_id":"R21AT003719","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G6362208079","display_name":"The Center for Native and Pacific Health Disparities Research","funder_award_id":"P20MD000173","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1571437386","https://openalex.org/W1594281275","https://openalex.org/W1964059126","https://openalex.org/W1964550779","https://openalex.org/W1969747946","https://openalex.org/W1973364600","https://openalex.org/W1982186516","https://openalex.org/W1997549625","https://openalex.org/W2002137163","https://openalex.org/W2012753961","https://openalex.org/W2017994898","https://openalex.org/W2043932983","https://openalex.org/W2050363846","https://openalex.org/W2053094449","https://openalex.org/W2054447845","https://openalex.org/W2059556382","https://openalex.org/W2069752613","https://openalex.org/W2074740541","https://openalex.org/W2078015793","https://openalex.org/W2078023359","https://openalex.org/W2087019732","https://openalex.org/W2091685314","https://openalex.org/W2092728526","https://openalex.org/W2093443640","https://openalex.org/W2094739392","https://openalex.org/W2119976307","https://openalex.org/W2120013671","https://openalex.org/W2120526866","https://openalex.org/W2123731635","https://openalex.org/W2136829516","https://openalex.org/W2141176449","https://openalex.org/W2147242092","https://openalex.org/W2153704476"],"related_works":["https://openalex.org/W1972008563","https://openalex.org/W2147097971","https://openalex.org/W4285791388","https://openalex.org/W1527047241","https://openalex.org/W2012614358","https://openalex.org/W2792870066","https://openalex.org/W4234394790","https://openalex.org/W4403341336","https://openalex.org/W2804392847","https://openalex.org/W2078015793"],"abstract_inverted_index":{"Sirtuin":[0],"activators,":[1],"including":[2],"small":[3],"molecules":[4],"such":[5],"as":[6,90],"polyphenols":[7],"and":[8,21,59],"resveratrol,":[9],"are":[10],"much":[11],"desired":[12],"due":[13],"to":[14,17,64],"their":[15],"potential":[16],"ameliorate":[18],"metabolic":[19],"disorder":[20],"delay":[22],"or":[23,39,83],"prevent":[24],"aging.":[25],"In":[26],"contrast,":[27],"recent":[28],"studies":[29],"demonstrate":[30],"that":[31],"targeted":[32,81],"silencing":[33],"of":[34,85,94],"sirtuin":[35],"1":[36,47],"(SIRT1)":[37],"expression":[38],"activity":[40,87],"by":[41,52,60],"the":[42],"deleted":[43],"in":[44,56,96],"breast":[45],"cancer":[46,57],"(DBC1)":[48],"may":[49],"be":[50],"beneficial":[51],"promoting":[53],"p53-induced":[54],"apoptosis":[55],"cells,":[58],"sensitizing":[61],"cancerous":[62],"cells":[63],"radiation":[65],"therapy.":[66],"Negative":[67],"SIRT1":[68,86],"regulation":[69,95],"also":[70],"alleviates":[71],"gene-repression":[72],"associated":[73],"with":[74],"fragile":[75],"X":[76],"mental":[77],"retardation":[78],"syndrome.":[79],"The":[80],"activation":[82],"inhibition":[84],"therefore":[88],"emerges":[89],"a":[91],"critical":[92],"point":[93],"disease":[97],"pathogenesis.":[98]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}