{"id":"https://openalex.org/W1066727159","doi":null,"title":"G\u03b1q-ASSOCIATED SIGNALING PROMOTES NEUROADAPTATION TO ETHANOL AND WITHDRAWAL-ASSOCIATED HIPPOCAMPAL DAMAGE","display_name":"G\u03b1q-ASSOCIATED SIGNALING PROMOTES NEUROADAPTATION TO ETHANOL AND WITHDRAWAL-ASSOCIATED HIPPOCAMPAL DAMAGE","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1066727159","mag":"1066727159"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:psychology_etds-1072","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/psychology_etds/74","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1072&context=psychology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Psychology","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1072&context=psychology_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029744190","display_name":"Anna R. Reynolds","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna R. Reynolds","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5029744190"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol-withdrawal","display_name":"ethanol withdrawal","score":0.7039999961853027},{"id":"https://openalex.org/keywords/group-i-metabotropic-glutamate-receptors","display_name":"group I metabotropic glutamate receptors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mglur1","display_name":"mGluR1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mglur5","display_name":"mGluR5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/galphaq-signaling","display_name":"G\u03b1q signaling","score":0.7170000076293945},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.6230000257492065},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/chronic-intermittent-ethanol-exposure","display_name":"chronic intermittent ethanol","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ethanol-dependence","display_name":"ethanol dependence","score":0.8320000171661377},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.7519999742507935},{"id":"https://openalex.org/keywords/alcohol-pharmacotherapy","display_name":"alcohol pharmacotherapy","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.7246638536453247},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.6226345300674438},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.5489169359207153},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.5456339716911316},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5347534418106079},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5320948958396912},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.5247014760971069},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49747851490974426},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4786580801010132},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.42118537425994873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3866483271121979},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3404957056045532},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.334155797958374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32543641328811646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.315346896648407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2706754207611084},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:psychology_etds-1072","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/psychology_etds/74","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1072&context=psychology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Psychology","raw_type":"text"},{"id":"mag:1066727159","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1072&context=psychology_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:psychology_etds-1072","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/psychology_etds/74","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1072&context=psychology_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Psychology","raw_type":"text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1830681032","display_name":null,"funder_award_id":"AA013388","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000899914","display_name":"Research Training in Drug Abuse Behavior","funder_award_id":"T32DA035200","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1066727159.pdf","grobid_xml":"https://content.openalex.org/works/W1066727159.grobid-xml"},"referenced_works_count":229,"referenced_works":["https://openalex.org/W67437489","https://openalex.org/W190287805","https://openalex.org/W648286435","https://openalex.org/W1485297825","https://openalex.org/W1498862479","https://openalex.org/W1517689773","https://openalex.org/W1528977425","https://openalex.org/W1536369380","https://openalex.org/W1576286569","https://openalex.org/W1576314909","https://openalex.org/W1581091695","https://openalex.org/W1595843790","https://openalex.org/W1599277155","https://openalex.org/W1601824490","https://openalex.org/W1615495952","https://openalex.org/W1731924710","https://openalex.org/W1762155833","https://openalex.org/W1771637006","https://openalex.org/W1814489004","https://openalex.org/W1827712693","https://openalex.org/W1849221297","https://openalex.org/W1856178333","https://openalex.org/W1871005505","https://openalex.org/W1918713759","https://openalex.org/W1930113898","https://openalex.org/W1934091218","https://openalex.org/W1963798303","https://openalex.org/W1967041207","https://openalex.org/W1967061503","https://openalex.org/W1967231563","https://openalex.org/W1968848936","https://openalex.org/W1969953568","https://openalex.org/W1970051522","https://openalex.org/W1970092595","https://openalex.org/W1973401628","https://openalex.org/W1975416249","https://openalex.org/W1975512870","https://openalex.org/W1975514200","https://openalex.org/W1977557088","https://openalex.org/W1978013837","https://openalex.org/W1978240991","https://openalex.org/W1978833864","https://openalex.org/W1981964580","https://openalex.org/W1982615438","https://openalex.org/W1982737894","https://openalex.org/W1983625516","https://openalex.org/W1983807711","https://openalex.org/W1983982251","https://openalex.org/W1984649085","https://openalex.org/W1985925989","https://openalex.org/W1986514475","https://openalex.org/W1987945524","https://openalex.org/W1992432409","https://openalex.org/W1992680021","https://openalex.org/W1994224293","https://openalex.org/W1994580609","https://openalex.org/W1994858112","https://openalex.org/W1995357866","https://openalex.org/W1995552213","https://openalex.org/W1996039145","https://openalex.org/W1997267167","https://openalex.org/W1997390821","https://openalex.org/W1998825594","https://openalex.org/W2000915741","https://openalex.org/W2001541852","https://openalex.org/W2001797086","https://openalex.org/W2002247919","https://openalex.org/W2002590408","https://openalex.org/W2003377853","https://openalex.org/W2003542395","https://openalex.org/W2005247333","https://openalex.org/W2005698755","https://openalex.org/W2005915948","https://openalex.org/W2006609374","https://openalex.org/W2007208778","https://openalex.org/W2007219916","https://openalex.org/W2007239691","https://openalex.org/W2007775198","https://openalex.org/W2008509697","https://openalex.org/W2009664257","https://openalex.org/W2010144291","https://openalex.org/W2017248136","https://openalex.org/W2018458388","https://openalex.org/W2018639131","https://openalex.org/W2019008364","https://openalex.org/W2019079031","https://openalex.org/W2019860424","https://openalex.org/W2020939963","https://openalex.org/W2021222157","https://openalex.org/W2021508451","https://openalex.org/W2024288146","https://openalex.org/W2024810183","https://openalex.org/W2026228200","https://openalex.org/W2028722367","https://openalex.org/W2030636484","https://openalex.org/W2031144646","https://openalex.org/W2031242571","https://openalex.org/W2031664178","https://openalex.org/W2031936045","https://openalex.org/W2032849758","https://openalex.org/W2034383331","https://openalex.org/W2034824489","https://openalex.org/W2035243589","https://openalex.org/W2037249096","https://openalex.org/W2037513419","https://openalex.org/W2038365303","https://openalex.org/W2040209778","https://openalex.org/W2041819617","https://openalex.org/W2046649654","https://openalex.org/W2046964321","https://openalex.org/W2047256549","https://openalex.org/W2047869246","https://openalex.org/W2048163838","https://openalex.org/W2050505630","https://openalex.org/W2051133054","https://openalex.org/W2054710811","https://openalex.org/W2055089906","https://openalex.org/W2055353932","https://openalex.org/W2057956870","https://openalex.org/W2058535388","https://openalex.org/W2058591676","https://openalex.org/W2059436730","https://openalex.org/W2059492625","https://openalex.org/W2062957466","https://openalex.org/W2064069776","https://openalex.org/W2066439059","https://openalex.org/W2066710952","https://openalex.org/W2069111099","https://openalex.org/W2069444651","https://openalex.org/W2070027885","https://openalex.org/W2070740099","https://openalex.org/W2071151533","https://openalex.org/W2071203240","https://openalex.org/W2072695890","https://openalex.org/W2072705969","https://openalex.org/W2072721148","https://openalex.org/W2072843066","https://openalex.org/W2073537077","https://openalex.org/W2074090118","https://openalex.org/W2074170871","https://openalex.org/W2075663070","https://openalex.org/W2076390838","https://openalex.org/W2076831122","https://openalex.org/W2077723068","https://openalex.org/W2077931642","https://openalex.org/W2078117880","https://openalex.org/W2078994454","https://openalex.org/W2080225008","https://openalex.org/W2081234982","https://openalex.org/W2081524870","https://openalex.org/W2082315075","https://openalex.org/W2082879602","https://openalex.org/W2083060011","https://openalex.org/W2083161970","https://openalex.org/W2084188201","https://openalex.org/W2086894916","https://openalex.org/W2086911005","https://openalex.org/W2088795865","https://openalex.org/W2089692573","https://openalex.org/W2090875715","https://openalex.org/W2091639948","https://openalex.org/W2092109656","https://openalex.org/W2092118181","https://openalex.org/W2092653742","https://openalex.org/W2092764200","https://openalex.org/W2093830143","https://openalex.org/W2093893470","https://openalex.org/W2099257531","https://openalex.org/W2099858791","https://openalex.org/W2100886729","https://openalex.org/W2103442566","https://openalex.org/W2104086074","https://openalex.org/W2105355442","https://openalex.org/W2106042714","https://openalex.org/W2108740579","https://openalex.org/W2116907077","https://openalex.org/W2118727048","https://openalex.org/W2118766025","https://openalex.org/W2121113404","https://openalex.org/W2122531239","https://openalex.org/W2123212921","https://openalex.org/W2123408217","https://openalex.org/W2123841796","https://openalex.org/W2124506252","https://openalex.org/W2124650677","https://openalex.org/W2124981502","https://openalex.org/W2125025104","https://openalex.org/W2126514544","https://openalex.org/W2128408332","https://openalex.org/W2134736026","https://openalex.org/W2135538727","https://openalex.org/W2136006910","https://openalex.org/W2139556398","https://openalex.org/W2139924686","https://openalex.org/W2140012877","https://openalex.org/W2140815944","https://openalex.org/W2140997424","https://openalex.org/W2145107163","https://openalex.org/W2145176659","https://openalex.org/W2145443131","https://openalex.org/W2146169076","https://openalex.org/W2147601519","https://openalex.org/W2150215474","https://openalex.org/W2152292563","https://openalex.org/W2157405529","https://openalex.org/W2158103834","https://openalex.org/W2158496649","https://openalex.org/W2158666090","https://openalex.org/W2158988264","https://openalex.org/W2159011576","https://openalex.org/W2160985876","https://openalex.org/W2161584310","https://openalex.org/W2162171501","https://openalex.org/W2166624443","https://openalex.org/W2166697225","https://openalex.org/W2168921260","https://openalex.org/W2169473035","https://openalex.org/W2170017401","https://openalex.org/W2170979974","https://openalex.org/W2171137970","https://openalex.org/W2174200381","https://openalex.org/W2189601384","https://openalex.org/W2333104709","https://openalex.org/W2339330854","https://openalex.org/W2410543146","https://openalex.org/W2422946400","https://openalex.org/W2982329434","https://openalex.org/W4233101943","https://openalex.org/W4298304997"],"related_works":["https://openalex.org/W2145445583","https://openalex.org/W2031144646","https://openalex.org/W2003377853","https://openalex.org/W2164397015","https://openalex.org/W2047829260","https://openalex.org/W2058181265","https://openalex.org/W2395448535","https://openalex.org/W2914574011","https://openalex.org/W1975416249","https://openalex.org/W1994493437"],"abstract_inverted_index":{"Prolonged,":[0],"heavy":[1,19,24],"consumption":[2,25],"of":[3,17,23,30,48,69,82,94,105,132,164,172,178,194,200],"alcohol":[4],"produces":[5,44],"marked":[6],"neuroadaptations":[7],"in":[8,38,79,86,107,141,175,182,203],"excitatory":[9],"neurotransmission.":[10],"These":[11],"effects":[12,104],"are":[13,26],"accelerated":[14],"following":[15],"patterns":[16],"intermittent":[18,124,156],"drinking":[20],"wherein":[21],"periods":[22,29,47],"followed":[27],"by":[28,65],"abstinence.":[31],"Studies":[32],"have":[33],"shown":[34],"that":[35,91],"neuroadaptive":[36],"changes":[37],"the":[39,67,102,130,162,170,176,198,204],"glutamatergic":[40],"N-methyl-D-aspartate":[41],"(NMDA)":[42],"receptor":[43],"excitotoxicity":[45],"during":[46],"withdrawal;":[49],"however,":[50],"upstream":[51],"targets":[52,64],"were":[53,120,152],"not":[54],"adequately":[55],"characterized.":[56],"The":[57],"present":[58],"studies":[59,187],"sought":[60],"to":[61,97,111,122,138,154,168,189],"identify":[62,112,190],"these":[63,173,186],"assessing":[66],"role":[68,171],"group":[70,134],"1":[71,135],"metabotropic":[72],"glutamate":[73],"receptors":[74,174],"(mGluR)":[75],"and":[76,100,113,191],"intracellular":[77],"calcium":[78],"promoting":[80],"cytotoxicity":[81,99,140],"hippocampal":[83,98,118],"cell":[84,143],"layers":[85],"vitro.":[87],"It":[88],"was":[89],"hypothesized":[90],"ethanol-induced":[92],"activity":[93],"mGluR1-and-5":[95],"contributes":[96],"promotes":[101],"behavioral":[103],"withdrawal":[106,183],"vivo.":[108],"In":[109,145],"order":[110],"test":[114],"this":[115],"theory,":[116],"rat":[117],"explants":[119],"co-exposed":[121,153],"chronic":[123,155],"ethanol":[125,157,201],"exposure":[126,158],"with":[127,159],"or":[128,160],"without":[129,161],"addition":[131,163],"a":[133,146],"mGluR":[136],"antagonist":[137,167],"assess":[139,169],"neuronal":[142],"types.":[144],"second":[147],"study,":[148],"adult":[149],"male":[150],"rodents":[151],"an":[165],"mGluR5":[166],"development":[177],"dependence":[179,202],"as":[180],"reflected":[181],"behaviors.":[184],"Together,":[185],"help":[188],"screen":[192],"toxicity":[193],"putative":[195],"pharmacotherapies":[196],"for":[197],"treatment":[199],"clinical":[205],"population.":[206]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}