{"id":"https://openalex.org/W10662955","doi":"https://doi.org/10.1200/jco.2015.33.7_suppl.20","title":"Epigenetic field effects: Potential applications for detection of occult high-grade prostate cancer.","display_name":"Epigenetic field effects: Potential applications for detection of occult high-grade prostate cancer.","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W10662955","doi":"https://doi.org/10.1200/jco.2015.33.7_suppl.20","mag":"10662955"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2015.33.7_suppl.20","doi":"https://doi.org/10.1200/jco.2015.33.7_suppl.20","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.7_suppl.20","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059034117","display_name":"Sandra Marlene Gaston","orcid":"https://orcid.org/0000-0002-0564-0459","observed_orcids":["https://orcid.org/0000-0002-0564-0459"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Marlene Gaston","raw_affiliation_strings":["Tufts Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Grizzle","raw_affiliation_strings":["Department of Pathology, University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009075484","display_name":"Leander Van Neste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leander Van Neste","raw_affiliation_strings":["Maastricht University, Maastricht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maastricht University, Maastricht, Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091611874","display_name":"Joseph W. Bigley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Bigley","raw_affiliation_strings":["MDxHealth, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MDxHealth, Irvine, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064153051","display_name":"James Yen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Yen","raw_affiliation_strings":["MDxHealth, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MDxHealth, Irvine, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010549946","display_name":"George Worthington Adams","orcid":"https://orcid.org/0000-0002-8831-157X","observed_orcids":["https://orcid.org/0000-0002-8831-157X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George W Adams","raw_affiliation_strings":["Urology Centers of Alabama, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology Centers of Alabama, Birmingham, AL","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113532008","display_name":"Gary P. Kearney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334126862","display_name":"New England Baptist Hospital","ror":"https://ror.org/01w50jw95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334126862"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary P Kearney","raw_affiliation_strings":["New England Baptist Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New England Baptist Hospital, Boston, MA","institution_ids":["https://openalex.org/I1334126862"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"7_suppl","first_page":"20","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.16979999840259552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/gstp1","display_name":"GSTP1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rassf1","display_name":"RASSF1","score":1.0},{"id":"https://openalex.org/keywords/gleason-grade","display_name":"Gleason grade","score":0.8820000290870667},{"id":"https://openalex.org/keywords/methylation-specific-pcr","display_name":"methylation-specific PCR","score":0.6639999747276306},{"id":"https://openalex.org/keywords/prostate-cancer-detection","display_name":"prostate cancer detection","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7767752408981323},{"id":"https://openalex.org/C2780122483","wikidata":"https://www.wikidata.org/wiki/Q18026593","display_name":"GSTP1","level":4,"score":0.7615824937820435},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7459933757781982},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6884800791740417},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6463028192520142},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6021851897239685},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.568691611289978},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.4187215268611908},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4134822487831116},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41114506125450134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36795711517333984},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32753974199295044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15423664450645447},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14569628238677979},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12594646215438843},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10065650939941406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08381387591362},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2015.33.7_suppl.20","doi":"https://doi.org/10.1200/jco.2015.33.7_suppl.20","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.7_suppl.20","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2591037790","https://openalex.org/W2742086776","https://openalex.org/W2402992073","https://openalex.org/W2576182598","https://openalex.org/W4234463670","https://openalex.org/W2989923923","https://openalex.org/W2336236850","https://openalex.org/W2590951422","https://openalex.org/W1970399158","https://openalex.org/W2049850518"],"abstract_inverted_index":{"20":[0,173],"Background:":[1],"Needle":[2],"biopsy":[3],"(Bx)":[4],"pathology":[5],"is":[6,72,94,339,368],"central":[7],"to":[8,45,96,99,116,119,155,370],"the":[9,53,61,88,120,206,212,217,236,244,251,269,283,303,317,323,327,335,361,371],"diagnosis":[10,259],"and":[11,66,135,144,187,215,231,290,301],"management":[12],"of":[13,26,63,78,104,122,151,161,169,209,266,285,305,319,337,347,363,373],"prostate":[14,131],"cancer":[15,47,177,219,324,333],"(PCa),":[16],"but":[17],"Bx":[18,171,311],"sampling":[19],"error":[20],"can":[21],"result":[22],"in":[23,40,59,69,211,216,235,309,322,341,351],"an":[24,123,364,374],"underestimate":[25],"Gleason":[27],"grade":[28],"(GS).":[29],"Epigenetic":[30],"DNA":[31,127],"hypermethylation":[32,68,210,233,267,289,308,320,338],"markers":[33],"associated":[34,73],"with":[35,74,175,181,189,243,316,353],"PCa":[36,184,192],"are":[37,52,85,107,114],"commonly":[38],"observed":[39,201,294],"histologically":[41],"benign":[42,70,213,237,310],"tissue":[43,133],"adjacent":[44],"a":[46,56,75,156,167,202],"focus.":[48],"Such":[49],"field":[50,306],"effects":[51],"basis":[54],"for":[55,87,137,141,225,248,295],"diagnostic":[57],"test":[58,91,366],"which":[60],"absence":[62],"GSTP1,":[64,142,299],"APC":[65,143,226,300],"RASSF1":[67],"Bxs":[71],"low":[76,82],"risk":[77],"\u201cmissed\u201d":[79],"PCa.":[80,125,376],"Relatively":[81],"methylation":[83,153],"thresholds":[84],"used":[86,136],"current":[89],"epigenetic":[90,111,365],"(ConfirmMDx)":[92],"that":[93,113,367],"designed":[95,115],"be":[97,117],"sensitive":[98,118,369],"any":[100],"occult":[101,124,375],"cancer,":[102],"regardless":[103],"GS.":[105,246],"We":[106],"evaluating":[108],"new":[109],"prototype":[110],"tests":[112],"GS":[121,182,190,252,260,270,277,286,292,331,348,354,372],"Methods:":[126],"was":[128,164,223,239,293,313],"extracted":[129],"from":[130,166,255,273,326],"bx":[132],"prints":[134],"quantitative":[138],"methylation-specific":[139],"PCR":[140],"RASSF1.":[145],"Results":[146],"were":[147],"computed":[148],"as":[149],"levels":[150,265],"marker":[152],"relative":[154],"common":[157],"reference":[158],"gene.":[159],"Each":[160],"12":[162],"cores":[163,214,238,254,272,312,325,346,356],"tested":[165],"series":[168],"102":[170],"patients:":[172],"diagnosed":[174],"no":[176],"(Group":[178,185,193],"1),":[179],"46":[180],"6":[183,253,271,287,332,355],"2)":[186],"36":[188],"7":[191,349],"3).":[194],"Results:":[195],"For":[196,229,298],"all":[197],"3":[198,257],"markers,":[199],"we":[200],"positive":[203],"correlation":[204,222,281],"between":[205,282],"highest":[207],"level":[208,284,318],"same-patient":[218],"cores.":[220],"This":[221],"strongest":[224,280],"(P":[227],"<0.0001).":[228],"GSTP1":[230],"APC,":[232],"intensity":[234,304,336],"also":[240,344],"positively":[241,314],"correlated":[242,315],"overall":[245,291],"Interestingly,":[247],"each":[249],"marker,":[250],"Group":[256,274],"(overall":[258,276],"7)":[261],"showed":[262],"significantly":[263],"higher":[264,340],"than":[268,350],"2":[275],"6).":[278],"The":[279],"core":[288],"GSTP1(P=0.0002).":[296],"Conclusions:":[297],"RASSF1,":[302],"effect":[307],"present":[321],"same":[328],"patient.":[329],"In":[330],"cores,":[334],"subjects":[342,352],"who":[343],"have":[345],"only.":[357],"Both":[358],"findings":[359],"support":[360],"feasibility":[362]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
