{"id":"https://openalex.org/W106607304","doi":null,"title":"Temporal kinetics of the light/dark translocation and compartmentation of arrestin and alpha-transducin in mouse photoreceptor cells.","display_name":"Temporal kinetics of the light/dark translocation and compartmentation of arrestin and alpha-transducin in mouse photoreceptor cells.","publication_year":2004,"publication_date":"2004-09-15","ids":{"openalex":"https://openalex.org/W106607304","mag":"106607304","pmid":"https://pubmed.ncbi.nlm.nih.gov/15467522"},"language":"en","primary_location":{"id":"pmid:15467522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15467522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064295198","display_name":"Rajesh V. Elias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126000","display_name":"Dean McGee Eye Institute","ror":"https://ror.org/036kn0x67","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210126000"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh V Elias","raw_affiliation_strings":["Department of Ophthalmology, Oklahoma University Health Sciences Center, Dean McGee Eye Institute, Oklahoma City 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Oklahoma University Health Sciences Center, Dean McGee Eye Institute, Oklahoma City 73104, USA","institution_ids":["https://openalex.org/I4210126000","https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steven S Sezate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven S Sezate","raw_affiliation_strings":["University of Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Cao","raw_affiliation_strings":["University of Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oklahoma","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109930880","display_name":"James F. McGinnis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James F McGinnis","raw_affiliation_strings":["Preclinical Translational Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Translational Cancer Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0255,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.92314961,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"672","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arrestin","display_name":"arrestin","score":0.824999988079071},{"id":"https://openalex.org/keywords/photoreceptors","display_name":"photoreceptors","score":0.7039999961853027},{"id":"https://openalex.org/keywords/subcellular-translocation","display_name":"subcellular translocation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/rod-outer-segments","display_name":"rod outer segments","score":0.8190000057220459},{"id":"https://openalex.org/keywords/light-adaptation","display_name":"light adaptation","score":0.6470000147819519},{"id":"https://openalex.org/keywords/dark-adaptation","display_name":"dark adaptation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cone-photoreceptors","display_name":"cone photoreceptors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mouse-retina","display_name":"mouse retina","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.8332450985908508},{"id":"https://openalex.org/C149574991","wikidata":"https://www.wikidata.org/wiki/Q420428","display_name":"Transducin","level":4,"score":0.8223330974578857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6689321994781494},{"id":"https://openalex.org/C131667965","wikidata":"https://www.wikidata.org/wiki/Q445081","display_name":"Visual phototransduction","level":3,"score":0.618403971195221},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.599197268486023},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5651013851165771},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49355876445770264},{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.471112996339798},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.3862614333629608},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.36428362131118774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2153725028038025},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18523037433624268},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.17902374267578125},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.0624634325504303},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003623","descriptor_name":"Dark Adaptation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014785","descriptor_name":"Vision, Ocular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015293","descriptor_name":"Transducin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019393","descriptor_name":"Arrestin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15467522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15467522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:106607304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15467522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1854954188","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY012190","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3948148410","display_name":"Mentoring Vision Research In Oklahoma","funder_award_id":"P20RR017703","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G692045879","display_name":"ANTIBODY-MEDIATED DEATH OF MAMMALIAN PHOTORECEPTOR CELLS","funder_award_id":"R01EY013050","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2001040160","https://openalex.org/W1968953822","https://openalex.org/W2049826872","https://openalex.org/W2138449618","https://openalex.org/W7100330183","https://openalex.org/W1999010404","https://openalex.org/W2141160298","https://openalex.org/W4398153098","https://openalex.org/W7209344668","https://openalex.org/W2092019931"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"the":[3,7,25,47,55,59,63,68,75,78,86,124,131,136,151,154,167,198,214,219,235,250,259,262,268,309,316,325],"temporal":[4],"kinetics":[5],"of":[6,10,28,49,58,74,77,85,88,106,114,141,153,156,223,252,267,290,305,318,327],"simultaneous":[8],"translocation":[9,79,113,152,204,251,269,291],"arrestin":[11,51,115,129,157,181,203,231],"and":[12,22,38,45,52,67,116,128,186,277],"rod":[13,50,60,64,125,132,236,276,295,328,333],"alpha-transducin":[14,30,53,117,142,208,307,329],"in":[15,54,83,109,123,130,145,166,230,249,275,320,330,341],"mice":[16,224],"exposed":[17],"to":[18,23,43,135,162,172,193,225,234,272,293,297,308],"different":[19],"lighting":[20,200,215],"environments":[21],"compare":[24],"subcellular":[26,56],"compartmentation":[27],"cone":[29,202,278,306,310],"with":[31,180,315,338],"arrestin.":[32],"METHODS:":[33],"Double":[34],"labeling":[35],"immunofluorescence":[36],"microscopy":[37],"image":[39],"analysis":[40],"are":[41,80,245],"used":[42],"visualize":[44],"quantify":[46],"concentrations":[48],"compartments":[57,121],"outer":[61,126,311,334],"segments,":[62],"inner":[65,133,237],"segments":[66],"synaptic":[69],"terminals.":[70],"RESULTS:":[71],"The":[72,104,287,302],"magnitude":[73],"effects":[76],"clearly":[81],"contrasted":[82],"images":[84],"retinas":[87,97],"animals":[89],"that":[90,98,243,261],"have":[91,99],"been":[92,100],"maximally":[93,101],"light":[94,107,171,226,285,298],"adapted":[95,332],"verses":[96],"dark":[102,300,331],"adapted.":[103],"onset":[105],"results":[108],"a":[110],"rapid,":[111],"simultaneous,":[112],"from":[118,170],"their":[119,339],"respective":[120],"(alpha-transducin":[122],"segment":[127,312,335],"segment)":[134],"opposite":[137,168],"compartment.":[138],"Almost":[139],"all":[140],"has":[143],"translocated":[144],"less":[146],"than":[147,190],"two":[148,254],"min":[149,185,192],"whereas":[150],"majority":[155],"requires":[158],"at":[159],"least":[160],"five":[161],"six":[163],"min.":[164],"Translocation":[165],"direction,":[169],"dark,":[173],"occurs":[174],"more":[175,189,263],"slowly":[176],"for":[177],"both":[178],"proteins":[179],"requiring":[182],"almost":[183],"30":[184],"alpha-T":[187],"needing":[188],"200":[191],"complete":[194],"its":[195],"journey.":[196],"Under":[197],"same":[199],"conditions,":[201],"is":[205,271,292,313,336],"incomplete.":[206],"Cone":[207],"does":[209,227],"not":[210,228],"translocate":[211],"under":[212],"any":[213],"conditions":[216],"tested.":[217],"Unlike":[218],"frog,":[220],"continuous":[221],"exposure":[222],"result":[229],"translocating":[232],"back":[233],"segment.":[238],"CONCLUSIONS:":[239],"These":[240],"data":[241],"suggest":[242],"there":[244],"four":[246],"mechanisms":[247],"involved":[248],"these":[253],"proteins.":[255],"They":[256],"also":[257],"support":[258],"conclusion":[260],"important":[264],"cellular":[265],"function":[266,289,317],"process":[270],"terminate":[273],"phototransduction":[274],"photoreceptors,":[279],"which":[280],"could":[281],"provide":[282],"protection":[283],"against":[284],"damage.":[286],"secondary":[288],"maximize":[294],"sensitivity":[296],"during":[299],"adaptation.":[301],"restricted":[303],"localization":[304],"consistent":[314,337],"cones":[319],"bright":[321],"light,":[322],"just":[323],"as":[324],"concentration":[326],"functioning":[340],"dim":[342],"light.":[343]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
