{"id":"https://openalex.org/W10607701","doi":null,"title":"EXERCISE AND DIABETES INFLUENCE ANTIOXIDANT ACTIVITY AND GENE EXPRESSION IN FEMALE RATS","display_name":"EXERCISE AND DIABETES INFLUENCE ANTIOXIDANT ACTIVITY AND GENE EXPRESSION IN FEMALE RATS","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W10607701","mag":"10607701"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.unl.edu:tnas-1038","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/tnas/39","pdf_url":"https://digitalcommons.unl.edu/context/tnas/article/1038/viewcontent/COMPLIANT_unl_tnas_1038.pdf","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Transactions of the Nebraska Academy of Sciences and Affiliated Societies","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.unl.edu/context/tnas/article/1038/viewcontent/COMPLIANT_unl_tnas_1038.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Janet Steele","orcid":"https://orcid.org/0000-0002-6051-5554","observed_orcids":["https://orcid.org/0000-0002-6051-5554"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet Steele","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6051-5554","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013637063","display_name":"Karynn E. Kucera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karynn E. Kucera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006120795","display_name":"Cory A. Ciccone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cory A. Ciccone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046509621","display_name":"Mary E. Connealy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary E. Connealy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0020645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.9380000233650208},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6930000185966492},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/aconitase","display_name":"aconitase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.847000002861023},{"id":"https://openalex.org/keywords/glutathione-synthetase","display_name":"glutathione synthetase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.6359999775886536},{"id":"https://openalex.org/keywords/kcnq1","display_name":"KCNQ1","score":0.8149999976158142},{"id":"https://openalex.org/keywords/kcnd2","display_name":"KCND2","score":0.8240000009536743},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.9100000262260437},{"id":"https://openalex.org/keywords/swimming-training","display_name":"swimming training","score":0.6340000033378601},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7739999890327454},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5961183905601501},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5762876868247986},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5756241083145142},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5407100319862366},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4620804786682129},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4251476526260376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3847324550151825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3482673168182373},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2860971689224243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13016954064369202}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.unl.edu:tnas-1038","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/tnas/39","pdf_url":"https://digitalcommons.unl.edu/context/tnas/article/1038/viewcontent/COMPLIANT_unl_tnas_1038.pdf","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Transactions of the Nebraska Academy of Sciences and Affiliated Societies","raw_type":"text"},{"id":"mag:10607701","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1038&context=tnas","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.unl.edu:tnas-1038","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/tnas/39","pdf_url":"https://digitalcommons.unl.edu/context/tnas/article/1038/viewcontent/COMPLIANT_unl_tnas_1038.pdf","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Transactions of the Nebraska Academy of Sciences and Affiliated Societies","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1609217704","display_name":"Nebraska Research Network in Functional Genomics","funder_award_id":"P20RR016469","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4493933010","display_name":null,"funder_award_id":"P20 RR16469","funder_id":"https://openalex.org/F4320309137","funder_display_name":"University of Nebraska Medical Center"}],"funders":[{"id":"https://openalex.org/F4320309137","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16"},{"id":"https://openalex.org/F4320312461","display_name":"University of Nebraska Kearney","ror":"https://ror.org/04d5mb615"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W10607701.pdf","grobid_xml":"https://content.openalex.org/works/W10607701.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W56179493","https://openalex.org/W58485037","https://openalex.org/W1577804997","https://openalex.org/W1792258694","https://openalex.org/W1820223973","https://openalex.org/W1880645720","https://openalex.org/W1943554009","https://openalex.org/W1967880298","https://openalex.org/W1974873586","https://openalex.org/W1981172893","https://openalex.org/W1983137097","https://openalex.org/W1983155198","https://openalex.org/W1989352421","https://openalex.org/W1991662012","https://openalex.org/W1991984425","https://openalex.org/W1993893812","https://openalex.org/W1998722759","https://openalex.org/W2002409083","https://openalex.org/W2002794726","https://openalex.org/W2004862085","https://openalex.org/W2006330191","https://openalex.org/W2013495405","https://openalex.org/W2017614800","https://openalex.org/W2042422714","https://openalex.org/W2047058067","https://openalex.org/W2049998591","https://openalex.org/W2050588921","https://openalex.org/W2061656768","https://openalex.org/W2070779934","https://openalex.org/W2071789967","https://openalex.org/W2079694518","https://openalex.org/W2086075948","https://openalex.org/W2101474138","https://openalex.org/W2104476914","https://openalex.org/W2116121809","https://openalex.org/W2119344352","https://openalex.org/W2122966855","https://openalex.org/W2131073646","https://openalex.org/W2134061562","https://openalex.org/W2136456480","https://openalex.org/W2138040307","https://openalex.org/W2142432219","https://openalex.org/W2143679973","https://openalex.org/W2144651037","https://openalex.org/W2146189359","https://openalex.org/W2146302436","https://openalex.org/W2148931927","https://openalex.org/W2150273946","https://openalex.org/W2158798910","https://openalex.org/W2160512793","https://openalex.org/W2168119070","https://openalex.org/W2168876074","https://openalex.org/W2173642994","https://openalex.org/W2181794173","https://openalex.org/W2183091930","https://openalex.org/W2229826246","https://openalex.org/W2291879083","https://openalex.org/W2412000279","https://openalex.org/W2442414805","https://openalex.org/W2907845564","https://openalex.org/W3141488140"],"related_works":["https://openalex.org/W2978409280","https://openalex.org/W3163166767","https://openalex.org/W2327844057","https://openalex.org/W2162576827","https://openalex.org/W3016931465","https://openalex.org/W2105118471","https://openalex.org/W4391919584","https://openalex.org/W2362532793","https://openalex.org/W6943120443","https://openalex.org/W2006618738"],"abstract_inverted_index":{"The":[0],"goal":[1],"of":[2,10,20,28,35,51,57,95,191],"this":[3],"study":[4],"was":[5,87,116,130,142,157],"to":[6,98,194],"examine":[7],"the":[8,18,33,49,55,189],"influence":[9],"exercise":[11],"training":[12,93,178],"and":[13,22,47,83,92,108,154,167,187],"type":[14],"I":[15],"diabetes":[16,183],"on":[17,26,32,48],"activity":[19,107,115],"aconitase":[21],"superoxide":[23],"dismutase":[24],"(SOD),":[25],"levels":[27,110],"reduced":[29],"glutathione":[30,39,45],"(GSH),":[31],"expression":[34,50,129,141,156,190],"genes":[36,52,192],"responsible":[37,53],"for":[38,54,103],"synthesis":[40],"(Gclc,":[41],"g-glutamylcysteine":[42],"synthase;":[43],"Gss,":[44],"synthetase),":[46],"formation":[56],"two":[58],"potassium":[59],"channels":[60],"(Kcnd2,":[61],"Ito;":[62],"KCNQl,":[63],"IKs)":[64],"in":[65,119,133,145,160,168],"cardiac":[66],"muscle.":[67],"Forty":[68],"female":[69],"Sprague-Dawley":[70],"rats":[71,122,135,148,162,166,170],"were":[72,111],"divided":[73],"into":[74],"four":[75],"groups:":[76],"sedentary":[77,79,125,151,165],"controls,":[78,82],"diabetics,":[80],"trained":[81,84,120,146,161],"diabetics.":[85],"Diabetes":[86],"induced":[88],"via":[89],"streptozotocin":[90],"injection,":[91],"consisted":[94],"swimming":[96],"up":[97],"2":[99],"hours":[100],"per":[101],"day":[102],"11":[104],"weeks.":[105],"Aconitase":[106],"GSH":[109],"unchanged,":[112],"but":[113],"SOD":[114],"significantly":[117,131,143],"elevated":[118],"diabetic":[121,126,134,147,152,169],"compared":[123,136,149,163,171],"with":[124,137,150,164,172,182],"rats.":[127,139,174],"Gss":[128],"downregulated":[132,144,159],"control":[138,173],"Kcnd2":[140],"rats,":[153],"KCNQl":[155],"consistently":[158],"These":[175],"results":[176],"suggest":[177],"alone":[179],"or":[180],"combined":[181],"increases":[184],"antioxidant":[185],"mechanisms":[186],"downregulates":[188],"related":[193],"K+":[195],"ion":[196],"channel":[197],"activity.":[198]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}