{"id":"https://openalex.org/W10567365","doi":null,"title":"Serotonin syndrome: case report and review of the literature.","display_name":"Serotonin syndrome: case report and review of the literature.","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W10567365","mag":"10567365","pmid":"https://pubmed.ncbi.nlm.nih.gov/9419960"},"language":"en","primary_location":{"id":"pmid:9419960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9419960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connecticut medicine","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112175945","display_name":"Alan L. Weiner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L Weiner","raw_affiliation_strings":["Connecticut Poison Control Center, USA. aweiner@harthosp.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connecticut Poison Control Center, USA. aweiner@harthosp.org","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084251804","display_name":"F F Tilden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F F Tilden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"C A McKay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A McKay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2541,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.54399918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"61","issue":"11","first_page":"717","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-syndrome","display_name":"serotonin syndrome","score":1.0},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/antidepressant-drug-interactions","display_name":"antidepressant drug interactions","score":0.6769999861717224},{"id":"https://openalex.org/keywords/tachycardia","display_name":"tachycardia","score":0.746999979019165},{"id":"https://openalex.org/keywords/delirium","display_name":"delirium","score":0.9700000286102295},{"id":"https://openalex.org/keywords/myoclonus","display_name":"myoclonus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cyproheptadine","display_name":"cyproheptadine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/depression-treatment","display_name":"depression treatment","score":0.5379999876022339},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2780179036","wikidata":"https://www.wikidata.org/wiki/Q616181","display_name":"Serotonin syndrome","level":5,"score":0.9062691926956177},{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.7553050518035889},{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.6755267381668091},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6585341691970825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6103983521461487},{"id":"https://openalex.org/C2780980600","wikidata":"https://www.wikidata.org/wiki/Q411457","display_name":"Trazodone","level":4,"score":0.6099467277526855},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5798451900482178},{"id":"https://openalex.org/C2910584757","wikidata":"https://www.wikidata.org/wiki/Q334477","display_name":"Serotonin Uptake Inhibitors","level":5,"score":0.5352028012275696},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.5263601541519165},{"id":"https://openalex.org/C2781068410","wikidata":"https://www.wikidata.org/wiki/Q421930","display_name":"Mirtazapine","level":4,"score":0.5057058334350586},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5052719712257385},{"id":"https://openalex.org/C2777393122","wikidata":"https://www.wikidata.org/wiki/Q416417","display_name":"Akathisia","level":4,"score":0.48077696561813354},{"id":"https://openalex.org/C2776538686","wikidata":"https://www.wikidata.org/wiki/Q116275","display_name":"Myoclonus","level":2,"score":0.44749897718429565},{"id":"https://openalex.org/C2779753318","wikidata":"https://www.wikidata.org/wiki/Q160796","display_name":"Delirium","level":2,"score":0.43213921785354614},{"id":"https://openalex.org/C2778689640","wikidata":"https://www.wikidata.org/wiki/Q113259","display_name":"Anticholinergic","level":2,"score":0.424589067697525},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.4244033694267273},{"id":"https://openalex.org/C2779305415","wikidata":"https://www.wikidata.org/wiki/Q58713","display_name":"Clomipramine","level":2,"score":0.41987860202789307},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30300790071487427},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2785227298736572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27026820182800293},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.2538226842880249},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.08554649353027344},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07190081477165222},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007099","descriptor_name":"Imipramine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007099","descriptor_name":"Imipramine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9419960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9419960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connecticut medicine","raw_type":"Case Reports"},{"id":"mag:10567365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9419960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010590942","https://openalex.org/W156612706","https://openalex.org/W2043033603","https://openalex.org/W2087727489","https://openalex.org/W2302495081","https://openalex.org/W1994700823","https://openalex.org/W67712000","https://openalex.org/W7219417063","https://openalex.org/W4406078634","https://openalex.org/W2139853742"],"abstract_inverted_index":{"We":[0],"present":[1],"the":[2,18,43,93,105],"case":[3,89],"of":[4,17,55,74,109],"a":[5,14,33,71,76],"35-year-old":[6],"woman":[7],"who":[8],"developed":[9,45],"serotonin":[10,35,56,77,99],"syndrome":[11],"after":[12,40],"receiving":[13,41],"single":[15],"dose":[16],"cyclic":[19],"antidepressant":[20],"imipramine":[21],"(Tofranil).":[22],"She":[23],"was":[24,64],"already":[25],"being":[26],"treated":[27,65],"for":[28,104],"depression":[29],"with":[30,66],"paroxetine":[31],"(Paxil),":[32],"selective":[34],"reuptake":[36],"inhibitor.":[37],"Two":[38],"hours":[39],"imipramine,":[42],"patient":[44],"tachycardia,":[46],"delirium,":[47],"bizarre":[48],"movements,":[49],"and":[50,62,70,101,107],"myoclonus,":[51],"all":[52],"classic":[53],"findings":[54],"syndrome.":[57],"Her":[58],"antidepressants":[59],"were":[60],"discontinued":[61],"she":[63],"intravenous":[67],"fluids,":[68],"sedation,":[69],"short":[72],"course":[73],"cyproheptadine,":[75],"receptor":[78],"antagonist.":[79],"All":[80],"symptoms":[81],"resolved":[82],"completely":[83],"within":[84],"24":[85],"hours.":[86],"In":[87],"this":[88,110],"report,":[90],"we":[91],"review":[92],"drug":[94],"interactions":[95],"that":[96],"can":[97],"precipitate":[98],"syndrome,":[100],"give":[102],"recommendations":[103],"diagnosis":[106],"treatment":[108],"potentially":[111],"fatal":[112],"disorder.":[113]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}