{"id":"https://openalex.org/W10546980","doi":null,"title":"[Mechanisms of nitric oxide synthesis and action in cells].","display_name":"[Mechanisms of nitric oxide synthesis and action in cells].","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W10546980","mag":"10546980","pmid":"https://pubmed.ncbi.nlm.nih.gov/12829875"},"language":"lt","primary_location":{"id":"pmid:12829875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12829875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030975572","display_name":"Vagan Arzumanian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vagan Arzumanian","raw_affiliation_strings":["Department of Physiology, Kaunas University of Medicine, A. Mickeviciaus 9, 3000 Kaunas, Lithuania. varzumanian@mail.lt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Kaunas University of Medicine, A. Mickeviciaus 9, 3000 Kaunas, Lithuania. varzumanian@mail.lt","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000740797","display_name":"Edgaras Stankev\u0131\u010d\u0131us","orcid":"https://orcid.org/0000-0003-2210-708X","observed_orcids":["https://orcid.org/0000-0003-2210-708X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edgaras Stankevicius","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039449923","display_name":"Al\u0117 Laukevi\u010dien\u0117","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ale Laukeviciene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040756931","display_name":"Egidijus K\u0117velaitis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Egidijus Kevelaitis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1898,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.52494778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"39","issue":"6","first_page":"535","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-isoforms","display_name":"nitric oxide synthase isoforms","score":0.9440000057220459},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8240000009536743},{"id":"https://openalex.org/keywords/heme","display_name":"heme","score":0.7120000123977661},{"id":"https://openalex.org/keywords/flavin-cofactor","display_name":"flavin cofactor","score":0.7540000081062317},{"id":"https://openalex.org/keywords/calcium-calmodulin-regulation","display_name":"calcium/calmodulin regulation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/nitric-oxide-signaling","display_name":"nitric oxide signaling","score":0.6909999847412109},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.9089130163192749},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.8930136561393738},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6627269387245178},{"id":"https://openalex.org/C91415057","wikidata":"https://www.wikidata.org/wiki/Q18030177","display_name":"NOS1","level":4,"score":0.6059474945068359},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5107495784759521},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.47925901412963867},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.47328585386276245},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.46231067180633545},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4363028109073639},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3478239178657532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2058081030845642},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05390247702598572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008961","descriptor_name":"Models, Structural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12829875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12829875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"English Abstract"},{"id":"pmh:oai:lsmu.lt:20.500.12512/72132","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/12829875","pdf_url":null,"source":{"id":"https://openalex.org/S7407055191","display_name":"Lithuanian University of Health Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"mag:10546980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12829875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2335890273"],"related_works":["https://openalex.org/W2494786083","https://openalex.org/W778933228","https://openalex.org/W2973614845","https://openalex.org/W4382195716","https://openalex.org/W55483475","https://openalex.org/W2103815234","https://openalex.org/W2916580457","https://openalex.org/W1993221086","https://openalex.org/W994102159","https://openalex.org/W1638354691"],"abstract_inverted_index":{"Nitric":[0],"oxide":[1,23,62,68,77,81,85,100,105,162,192,230,237],"(NO)":[2],"is":[3,9,33,63,158],"a":[4,10,34],"free":[5],"radical":[6],"gas,":[7],"which":[8,32,71],"product":[11],"of":[12,21,36,60,90,128,166,203,216,223,228,246],"reaction":[13],"between":[14,170],"molecular":[15,171],"oxygen":[16,172],"and":[17,102,113,121,150,173,183,210,231,249],"L-arginine.":[18,174],"Great":[19],"diffusibility":[20],"nitric":[22,37,61,67,76,80,84,99,104,161,191,229,236],"determines":[24],"its":[25,206,241],"quick":[26],"three-dimensional":[27],"distribution":[28],"around":[29],"the":[30,126,198,235],"cell":[31],"source":[35],"oxide.":[38],"Single":[39],"electron":[40],"makes":[41],"it":[42],"into":[43],"very":[44],"reactive":[45],"radical,":[46],"interacting":[47],"with":[48],"metals":[49],"incorporated":[50],"in":[51,111,125,135,190,244],"enzyme":[52,66],"structure,":[53],"heme,":[54],"superoxids,":[55],"oxygen,":[56],"etc.":[57],"The":[58,225],"synthesis":[59],"catalyzed":[64],"by":[65,139],"synthase":[69,101,163,238],"(NOS)":[70],"has":[72,205],"three":[73],"isoforms:":[74],"endothelial":[75],"synthase,":[78,82],"neuronal":[79],"macrophagal":[83],"synthase.":[86,106,193],"Due":[87],"to":[88],"mechanisms":[89],"action":[91],"NOS":[92],"enzymes":[93],"are":[94,109,116,122,133,151,185],"also":[95],"classified":[96],"as":[97,154,187,219,221],"constitutive":[98],"inducible":[103],"Constitutive":[107],"forms":[108,132],"found":[110,186],"cytosol":[112],"membranes,":[114],"they":[115],"dependent":[117],"on":[118,147,178],"Ca(2+)/calmodulin":[119,148],"concentration":[120,149],"extremely":[123],"important":[124],"regulation":[127,245],"physiological":[129,248],"processes.":[130,251],"Inducible":[131],"synthesized":[134],"cells":[136],"after":[137],"induction":[138],"bacterial":[140],"endotoxins":[141],"or":[142],"cytokines,":[143],"do":[144],"not":[145],"depend":[146],"being":[152],"considered":[153],"pathological":[155],"isoforms.":[156],"It":[157],"thought":[159],"that":[160,180],"catalyses":[164],"transport":[165],"electrons":[167],"for":[168],"reactions":[169],"This":[175],"consideration":[176],"based":[177],"fact":[179],"flavine":[181],"co-enzymes":[182],"hem":[184],"structural":[188],"units":[189],"Although":[194],"all":[195],"isoforms":[196,239],"catalyze":[197],"same":[199],"reactions,":[200],"every":[201],"one":[202],"them":[204],"own":[207],"unique":[208],"structure":[209],"localization.":[211],"These":[212],"features":[213,227],"determine":[214,240],"differences":[215,233],"activation":[217],"pathways":[218],"well":[220],"specificity":[222],"inhibitors.":[224],"characteristic":[226],"functional":[232],"among":[234],"different":[242],"role":[243],"many":[247],"pathophysiological":[250]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}