{"id":"https://openalex.org/W105264746","doi":null,"title":"Standardised, metabolite-specific assays with validated decision limits: utopian ideal or achievable goal?","display_name":"Standardised, metabolite-specific assays with validated decision limits: utopian ideal or achievable goal?","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W105264746","mag":"105264746","pmid":"https://pubmed.ncbi.nlm.nih.gov/16278772","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1240024"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:86851","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1240024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1240024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028903138","display_name":"Paul Glendenning","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paul Glendenning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028903138"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":"3","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11890","display_name":"Scientific Measurement and Uncertainty Evaluation","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/3105","display_name":"Instrumentation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/assay-standardization","display_name":"assay standardization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8610000014305115},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.972000002861023},{"id":"https://openalex.org/keywords/total-testosterone","display_name":"total testosterone","score":0.8479999899864197},{"id":"https://openalex.org/keywords/reference-method","display_name":"reference method","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.48502108454704285},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4128498435020447},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37729305028915405},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.34083157777786255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32608678936958313},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.32252973318099976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29070591926574707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.288560688495636},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1990734338760376},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1767270863056183}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:86851","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1240024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:16278772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16278772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Clinical biochemist. Reviews","raw_type":"Editorial"},{"id":"pmh:oai:pubmedcentral.nih.gov:1240024","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1240024/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Biochem Rev","raw_type":"Text"},{"id":"mag:105264746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16278772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:86851","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1240024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2044855260","https://openalex.org/W2062126815","https://openalex.org/W2144756371","https://openalex.org/W2157527766","https://openalex.org/W2237568148"],"related_works":["https://openalex.org/W2029745422","https://openalex.org/W570684438","https://openalex.org/W93284657","https://openalex.org/W3029624164","https://openalex.org/W1938493452","https://openalex.org/W2079323542","https://openalex.org/W4241367360","https://openalex.org/W2048307056","https://openalex.org/W4212844516","https://openalex.org/W161350945"],"abstract_inverted_index":{"This":[0,317,637],"issue":[1,158,290],"of":[2,11,57,68,159,162,167,176,186,256,274,301,313,323,347,363,384,387,410,453,475,531,535,583,587,607,634,702,721],"Clinical":[3,314],"Biochemist":[4],"Reviews":[5],"is":[6,88,203,292,297,394,503,570,574,586,638,694],"dedicated":[7],"to":[8,54,90,241,320,401,420,425,441,469,552,560,629,648,666,714],"the":[9,16,58,63,76,107,148,160,163,174,184,195,228,248,278,299,310,327,330,341,357,364,385,529,536,564,575,579,631,690,716,719],"study":[10],"assays":[12,41,70,100,132,146,169,211,214,260,325,405,463,593,599,643,668,678,688,711],"commonly":[13,73],"used":[14,74,647],"in":[15,30,75,106,136,147,156,205,227,235,277,288,298,326,329,361,374,380,499,514,528,545,618,653,673,689,705,718],"endocrine":[17,77,149,691],"area.":[18,150],"We":[19],"have":[20,101,133,142],"also":[21],"introduced":[22],"a":[23,48,103,265,303,454,504,511,532,541],"new":[24,114],"feature":[25],"called":[26],"Analytical":[27],"Commentaries.":[28],"Articles":[29],"this":[31,55,118,157,236,289,355,393,492,500,674],"section":[32,56],"will":[33,170,354,399],"summarise":[34],"recent":[35],"assay":[36,115,281,338,397,426,608,623,635],"development":[37,64,116,175,282],"and":[38,65,84,95,110,120,138,212,220,232,253,258,272,291,369,377,396,432,448,451,473,491,578,603,610,620,625,662,679,697,709],"critique":[39],"current":[40,66],"but":[42,179,557],"are":[43,60,72,351,406,594,600,614,627,644,669],"not":[44,177,460],"as":[45,47,98,225,294,572,616,641,655,657],"comprehensive":[46,154,382],"review":[49,155,383],"article.":[50],"Future":[51],"unsolicited":[52],"contributions":[53],"journal":[59],"welcome.\r\n\r\nWe":[61],"explore":[62],"limitations":[67,606],"three":[69],"that":[71,130,141,371,506,585],"area:":[78],"HbA1c,":[79],"25":[80],"hydroxyvitamin":[81],"D":[82],"(25OHD)":[83],"total":[85,96,487,619],"testosterone.":[86],"It":[87,693],"pertinent":[89,640],"compare":[91],"HbA1c":[92,99,131,168,251],"with":[93,222,524,566],"25OHD":[94,213,259,307,324,366,412,443,708],"testosterone":[97,210,257,488,519,577,584,598,622,642,667,710],"come":[102],"long":[104],"way":[105,239],"last":[108],"decade":[109],"standardisation":[111,166,243,252,255,322,336,498],"has":[112,127,244,283],"assisted":[113],"for":[117,183,306,408,428,486,686,699,707],"analyte":[119],"reduced":[121],"inter-method":[122,218],"bias.":[123],"So":[124],"much":[125],"progress":[126,249],"been":[128,245,284],"achieved":[129,134,263],"improvements":[135,617,704],"precision":[137],"inter-assay":[139],"agreement":[140],"surpassed":[143],"most":[144,687],"other":[145,439,660],"Readers":[151],"perusing":[152],"Goodall\u2019s":[153],"history":[161],"efforts":[164],"at":[165],"be":[171,262,418,438,461],"impressed":[172],"by":[173,230,247,286,309,337,510,671],"one":[178],"two":[180,365],"definitive":[181],"methods":[182],"quantification":[185],"HbA1c.":[187,700],"Futhermore,":[188],"despite":[189],"many":[190],"potential":[191],"glycated":[192,200],"moieties,":[193],"only":[194,481],"major":[196],"fraction,":[197],"N-terminal":[198],"valine":[199],"hexapeptide":[201],"protein,":[202],"quantified":[204],"these":[206],"methods.":[207],"In":[208,340,479,562],"comparison,":[209],"suffer":[215,464,604],"from":[216,445,465,605],"significant":[217],"bias":[219],"problems":[221,358],"metabolite":[223,471],"recognition":[224,362,472],"outlined":[226],"articles":[229],"Sacks":[231],"Wootton":[233,287,372,433],"respectively":[234],"issue.":[237],"The":[238,659],"forward":[240],"achieving":[242],"illuminated":[246],"towards":[250],"global":[254],"could":[261],"using":[264],"similar":[266,466,703],"strategy.":[267],"But":[268,353],"what":[269],"do":[270,276],"laboratories":[271,275],"users":[273],"interim":[279],"period?\r\n\r\n25OHD":[280],"reviewed":[285],"appropriate":[293,476],"RMIT":[295],"University":[296],"process":[300],"establishing":[302],"reference":[304],"method":[305,485,495],"supported":[308],"Australasian":[311],"Association":[312],"Biochemists":[315],"(AACB).":[316],"should":[318,712],"help":[319,649,713],"improve":[321,497],"region":[328],"short":[331],"term":[332],"whilst":[333],"we":[334,417],"await":[335],"manufacturers.":[339],"immediate":[342],"term,":[343],"I":[344,390],"believe":[345],"application":[346,452,474],"assay-specific":[348],"decision":[349,423,456,477,683],"limits":[350,424,684],"needed.1":[352],"resolve":[356],"regarding":[359],"equity":[360],"metabolites,":[367],"25OHD2":[368],"25OHD3":[370],"outlines":[373],"his":[375,381],"article":[376],"Morris":[378,431],"identifies":[379],"area":[386],"vitamin":[388],"D?":[389],"don\u2019t":[391],"think":[392],"likely":[395],"manufacturers":[398],"need":[400],"consider":[402],"whether":[403],"separate":[404],"required":[407],"measurement":[409],"each":[411],"metabolite.":[413],"Only":[414],"then":[415],"may":[416,437,458,496],"able":[419],"apply":[421],"single":[422,455],"results":[427],"25OHD.":[429],"As":[430],"both":[434],"emphasise,":[435],"there":[436],"reasons":[440],"measure":[442],"apart":[444],"calcium":[446],"homeostasis":[447],"skeletal":[449],"health":[450],"limit":[457,715],"still":[459],"achievable.\r\n\r\nTestosterone":[462],"issues":[467,613,664],"relating":[468],"standardisation,":[470,676],"limits.":[478],"fact,":[480],"recently,":[482],"another":[483],"reference/definitive":[484],"was":[489],"published":[490],"mass":[493],"spectrometric":[494],"area.2":[501],"Testosterone":[502,548],"prehormone":[505],"requires":[507],"metabolic":[508],"activation":[509],"hydroxylation":[512],"step":[513],"androgen":[515,651],"sensitive":[516],"tissues.":[517],"However,":[518],"values":[520,526],"usually":[521],"correlate":[522],"well":[523,656,680],"dihydrotestosterone":[525],"except":[527],"presence":[530],"rare":[533],"disorder":[534],"5-alpha":[537],"reductase":[538],"gene":[539],"or":[540],"drug":[542],"induced":[543],"change":[544],"enzyme":[546],"activity.":[547],"circulates":[549],"highly":[550],"bound":[551,559,581],"sex":[553],"hormone":[554,568,592],"binding":[555],"globulin":[556],"weakly":[558],"albumin.":[561],"fact":[563],"analogy":[565],"thyroid":[567,591],"measurements":[569],"apt":[571],"it":[573],"free":[576,590,597,621],"weakly-albumin":[580],"fraction":[582],"interest.":[588],"Whilst":[589],"readily":[595],"available,":[596],"relatively":[601],"uncommon":[602],"insensitivity":[609,652],"bias.3":[611],"These":[612],"important":[615],"sensitivity":[624],"specificity":[626],"needed":[628],"meet":[630],"clinical":[632,682],"needs":[633],"users.":[636],"especially":[639],"being":[645],"increasingly":[646],"define":[650],"women":[654],"men.4":[658],"pre-":[661],"post-analytical":[663],"related":[665],"addressed":[670],"Coates":[672],"issue.\r\n\r\nAre":[675],"metabolite-specific":[677],"validated":[681],"achievable":[685,698],"area?":[692],"certainly":[695],"possible":[696],"Achievement":[701],"quality":[706],"guesswork":[717],"provision":[720],"laboratory":[722],"results.5":[723]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}