{"id":"https://openalex.org/W105137101","doi":"https://doi.org/10.22029/eir.2010.1658","title":"The stress response of the liver to physical exercise","display_name":"The stress response of the liver to physical exercise","publication_year":2026,"publication_date":"2026-07-15","ids":{"openalex":"https://openalex.org/W105137101","doi":"https://doi.org/10.22029/eir.2010.1658","mag":"105137101","pmid":"https://pubmed.ncbi.nlm.nih.gov/20839498"},"language":"en","primary_location":{"id":"pmid:20839498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20839498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.22029/eir.2010.1658","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014505944","display_name":"Miriam Hoene","orcid":"https://orcid.org/0000-0001-7014-1501","observed_orcids":["https://orcid.org/0000-0001-7014-1501"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hoene, Miriam","raw_affiliation_strings":["Univ Tubingen Hosp, Dept Internal Med, Div Endocrinol Diabetol Angiol Nephrol Pathobioch, Tubingen, Germany","Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Tubingen Hosp, Dept Internal Med, Div Endocrinol Diabetol Angiol Nephrol Pathobioch, Tubingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033072669","display_name":"Cora Weigert","orcid":"https://orcid.org/0000-0003-0358-776X","observed_orcids":["https://orcid.org/0000-0003-0358-776X"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Weigert, Cora","raw_affiliation_strings":["Univ Tubingen Hosp, Dept Internal Med, Div Endocrinol Diabetol Angiol Nephrol Pathobioch, Tubingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Tubingen Hosp, Dept Internal Med, Div Endocrinol Diabetol Angiol Nephrol Pathobioch, Tubingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.00025016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":null,"first_page":"163","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.6010000109672546},{"id":"https://openalex.org/keywords/acute-exercise","display_name":"acute exercise","score":0.847000002861023},{"id":"https://openalex.org/keywords/exercise-stress-response","display_name":"exercise stress response","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hepatic-gene-expression","display_name":"hepatic gene expression","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6729999780654907},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gadd45gamma","display_name":"GADD45\u03b3","score":0.9459999799728394},{"id":"https://openalex.org/keywords/igfbp-1","display_name":"IGFBP-1","score":0.824999988079071},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.875},{"id":"https://openalex.org/keywords/energy-depletion","display_name":"energy depletion","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.6639999747276306},{"id":"https://openalex.org/keywords/training-adaptation","display_name":"training effects","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6011882424354553},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5838522911071777},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5812225341796875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5582529306411743},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.4906283915042877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48476141691207886},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4452442526817322},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4389134347438812},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3489798307418823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3354582190513611},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3158297538757324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3128190040588379},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22257089614868164},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15341931581497192}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:20839498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20839498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Journal Article"},{"id":"doi:10.22029/eir.2010.1658","doi":"https://doi.org/10.22029/eir.2010.1658","is_oa":true,"landing_page_url":"https://doi.org/10.22029/eir.2010.1658","pdf_url":null,"source":{"id":"https://openalex.org/S7407052994","display_name":"Universit\u00e4tsbibliothek Gie\u00dfen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200763008","host_organization_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","host_organization_lineage":["https://openalex.org/I200763008"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"mag:105137101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20839498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.22029/eir.2010.1658","doi":"https://doi.org/10.22029/eir.2010.1658","is_oa":true,"landing_page_url":"https://doi.org/10.22029/eir.2010.1658","pdf_url":null,"source":{"id":"https://openalex.org/S7407052994","display_name":"Universit\u00e4tsbibliothek Gie\u00dfen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200763008","host_organization_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","host_organization_lineage":["https://openalex.org/I200763008"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1989214045","https://openalex.org/W1555224456","https://openalex.org/W2895615073","https://openalex.org/W3125740022","https://openalex.org/W3091928142","https://openalex.org/W2912706601","https://openalex.org/W4308683402","https://openalex.org/W2095245731","https://openalex.org/W2233967689","https://openalex.org/W7098305195"],"abstract_inverted_index":{"Recent":[0],"research":[1],"on":[2,88],"the":[3,23,36,39,53,57,75,124,129,140,148,172,205,216,229,235,241,253,275,279,285,300,311,326,330],"effectiveness":[4],"of":[5,11,22,38,83,119,123,139,147,152,164,171,209,218,248,268,278,303,329],"training":[6],"interventions":[7],"indicates":[8],"major":[9],"alterations":[10],"hepatic":[12,77,103,120,210],"lipid":[13],"metabolism":[14],"and":[15,19,46,60,151,176,180,183,238,250],"suggests":[16],"a":[17,112,136,160],"substantial":[18],"beneficial":[20],"adaptation":[21],"liver":[24,58,130,230,242,280,331],"to":[25,43,79,96,132,245,264,281,299,310,321,325,332],"regular":[26],"physical":[27,63],"activity":[28],"in":[29,56,71,108,159,228,234,252],"humans.":[30],"However,":[31],"while":[32],"various'":[33],"data":[34],"demonstrate":[35],"response":[37,78,95,166,270],"working":[40,236,286],"skeletal":[41],"muscle":[42,287],"acute":[44,76,93,133],"exercise":[45,84,98,134,214,223],"training,":[47],"considerably":[48],"less":[49],"is":[50,215,243],"known":[51],"about":[52],"molecular":[54,315],"events":[55,316],"during":[59,239],"after":[61,213],"increased":[62,265],"activity.":[64],"Here":[65],"we":[66],"discuss":[67],"recent":[68],"studies":[69],"performed":[70],"rodents,":[72],"that":[73,128,274,297],"elucidate":[74],"one":[80,97],"single":[81],"bout":[82,99],"with":[85,111,135],"particular":[86],"emphasis":[87],"stress":[89,165,269,296,322],"response-related":[90],"pathways.":[91],"The":[92],"transcriptional":[94,162],"comprises":[100],"three-times":[101],"more":[102,114],"transcripts":[104],"than":[105],"those":[106],"expressed":[107],"soleus":[109],"muscle,":[110,237],"significantly":[113],"pronounced":[115],"up-":[116],"or":[117],"downregulation":[118],"genes.":[121,271],"Evaluation":[122],"affected":[125],"pathways":[126],"shows":[127],"responds":[131],"rapid":[137],"activation":[138],"mitogen-activated":[141],"protein":[142,195],"kinase":[143],"(MAPK)":[144],"signalling":[145,156],"pathway,":[146],"p53":[149],"protein,":[150],"interleukin":[153],"(IL)-6-type":[154],"cytokine":[155],"pathways,":[157],"resulting":[158],"marked":[161,206,301],"upregulation":[163],"genes":[167,184,211],"(e.g.,":[168],"transcription":[169],"factors":[170],"Fos/Jun-family,":[173],"growth":[174,192],"arrest":[175],"DNA":[177],"damage":[178],"(GADD)45gamma,":[179],"p53-target":[181],"genes)":[182],"typically":[185],"induced":[186],"by":[187],"energy":[188,224],"depletion,":[189],"e.g.,":[190],"insulin-like":[191],"factor":[193],"binding":[194],"(IGFBP)-1,":[196],"peroxisome":[197],"proliferator-activated":[198],"receptor":[199],"coactivator":[200],"(PGC)1alpha.":[201],"One":[202],"explanation":[203],"for":[204,284,293],"differential":[207],"expression":[208,266],"immediately":[212],"induction":[217,302],"energetic":[219],"stress.":[220],"After":[221],"non-exhaustive":[222],"depletion":[225],"predominantly":[226],"occurs":[227],"not":[231,319],"as":[232],"much":[233],"exercise,":[240],"exposed":[244],"altered":[246],"concentrations":[247],"insulin":[249],"glucagon":[251],"portal":[254],"vein.":[255],"Furthermore,":[256],"lower":[257],"plasma":[258],"glucose":[259,283],"levels":[260,267],"post-exercise":[261],"are":[262,317],"related":[263],"It":[272],"appears":[273],"unique":[276],"function":[277],"supply":[282],"renders":[288],"this":[289],"organ":[290],"especially":[291],"susceptible":[292],"exercise-induced":[294],"cellular":[295],"leads":[298],"defense":[304,323],"adaptations.":[305],"These":[306],"results":[307],"give":[308],"rise":[309],"question":[312],"whether":[313],"these":[314],"linked":[318],"only":[320],"but":[324],"metabolic":[327],"adaptations":[328],"exercise.":[333]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
