{"id":"https://openalex.org/W105041445","doi":null,"title":"Funktionelle Charakterisierung von Mutationen im Synphilin-1- und Parkin-Gen bei der Parkinson-Krankheit : Bedeutung von Proteinaggregation und des Ubiquitin-Proteasomen-Systems f\u00fcr die Pathogenese der Parkinson-Krankheit","display_name":"Funktionelle Charakterisierung von Mutationen im Synphilin-1- und Parkin-Gen bei der Parkinson-Krankheit : Bedeutung von Proteinaggregation und des Ubiquitin-Proteasomen-Systems f\u00fcr die Pathogenese der Parkinson-Krankheit","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W105041445","mag":"105041445"},"language":"de","primary_location":{"id":"mag:105041445","doi":null,"is_oa":false,"landing_page_url":"https://publikationen.uni-tuebingen.de/xmlui/handle/10900/48692","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111403175","display_name":"Frank P. Marx","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Frank P. Marx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111403175"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7490000128746033},{"id":"https://openalex.org/keywords/synphilin-1","display_name":"synphilin-1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.5230000019073486},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.6079999804496765},{"id":"https://openalex.org/keywords/functional-characterization","display_name":"functional characterization","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.44984009861946106},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3700264096260071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33351635932922363},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.26381826400756836},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06725353002548218},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:105041445","doi":null,"is_oa":false,"landing_page_url":"https://publikationen.uni-tuebingen.de/xmlui/handle/10900/48692","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W138616876","https://openalex.org/W200542940","https://openalex.org/W1489341550","https://openalex.org/W1498629854","https://openalex.org/W1515490675","https://openalex.org/W1515882803","https://openalex.org/W1518893426","https://openalex.org/W1521854746","https://openalex.org/W1529474377","https://openalex.org/W1546234190","https://openalex.org/W1550876205","https://openalex.org/W1618846043","https://openalex.org/W1620862744","https://openalex.org/W1637321639","https://openalex.org/W1776539077","https://openalex.org/W1780544763","https://openalex.org/W1832030339","https://openalex.org/W1864905496","https://openalex.org/W1877873625","https://openalex.org/W1921484215","https://openalex.org/W1952548524","https://openalex.org/W1960315548","https://openalex.org/W1965445334","https://openalex.org/W1965778124","https://openalex.org/W1967684210","https://openalex.org/W1969571310","https://openalex.org/W1969800514","https://openalex.org/W1971389338","https://openalex.org/W1972646996","https://openalex.org/W1972939055","https://openalex.org/W1976316003","https://openalex.org/W1976345822","https://openalex.org/W1979527613","https://openalex.org/W1981862471","https://openalex.org/W1982760518","https://openalex.org/W1986188355","https://openalex.org/W1986625112","https://openalex.org/W1986896647","https://openalex.org/W1988146888","https://openalex.org/W1990115112","https://openalex.org/W1991198986","https://openalex.org/W1991241547","https://openalex.org/W1991930087","https://openalex.org/W1998180291","https://openalex.org/W1999893655","https://openalex.org/W2000409052","https://openalex.org/W2000769077","https://openalex.org/W2001407922","https://openalex.org/W2001573404","https://openalex.org/W2002223631","https://openalex.org/W2002985134","https://openalex.org/W2007232689","https://openalex.org/W2007316513","https://openalex.org/W2009629707","https://openalex.org/W2011777799","https://openalex.org/W2013411719","https://openalex.org/W2013558716","https://openalex.org/W2013784514","https://openalex.org/W2014300038","https://openalex.org/W2014444130","https://openalex.org/W2019978095","https://openalex.org/W2020516313","https://openalex.org/W2024891592","https://openalex.org/W2025922492","https://openalex.org/W2027649342","https://openalex.org/W2028806152","https://openalex.org/W2032212474","https://openalex.org/W2032373330","https://openalex.org/W2032817175","https://openalex.org/W2032965748","https://openalex.org/W2034484654","https://openalex.org/W2035145745","https://openalex.org/W2035531816","https://openalex.org/W2038557175","https://openalex.org/W2038561603","https://openalex.org/W2041734419","https://openalex.org/W2042201192","https://openalex.org/W2044296969","https://openalex.org/W2044320834","https://openalex.org/W2049327371","https://openalex.org/W2050786534","https://openalex.org/W2051651977","https://openalex.org/W2052937897","https://openalex.org/W2053680640","https://openalex.org/W2054848243","https://openalex.org/W2055308573","https://openalex.org/W2056127416","https://openalex.org/W2058855163","https://openalex.org/W2059362512","https://openalex.org/W2059737503","https://openalex.org/W2061259632","https://openalex.org/W2062250460","https://openalex.org/W2062833196","https://openalex.org/W2063022868","https://openalex.org/W2066433054","https://openalex.org/W2066842081","https://openalex.org/W2067340670","https://openalex.org/W2069553229","https://openalex.org/W2071336988","https://openalex.org/W2076344205","https://openalex.org/W2077260129","https://openalex.org/W2079295410","https://openalex.org/W2079647016","https://openalex.org/W2081103757","https://openalex.org/W2082861241","https://openalex.org/W2087528807","https://openalex.org/W2089440318","https://openalex.org/W2089460219","https://openalex.org/W2091265794","https://openalex.org/W2093582406","https://openalex.org/W2094428357","https://openalex.org/W2096966529","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2101362932","https://openalex.org/W2104382960","https://openalex.org/W2104912043","https://openalex.org/W2108134679","https://openalex.org/W2109040303","https://openalex.org/W2111301002","https://openalex.org/W2116598203","https://openalex.org/W2117396432","https://openalex.org/W2119520931","https://openalex.org/W2120817143","https://openalex.org/W2120947942","https://openalex.org/W2122551230","https://openalex.org/W2123781000","https://openalex.org/W2128635872","https://openalex.org/W2132068224","https://openalex.org/W2132417094","https://openalex.org/W2133155833","https://openalex.org/W2133916339","https://openalex.org/W2134786936","https://openalex.org/W2135387829","https://openalex.org/W2136372119","https://openalex.org/W2136388422","https://openalex.org/W2136661211","https://openalex.org/W2137849205","https://openalex.org/W2141429139","https://openalex.org/W2142780460","https://openalex.org/W2143959688","https://openalex.org/W2144634347","https://openalex.org/W2146908971","https://openalex.org/W2150656456","https://openalex.org/W2151198603","https://openalex.org/W2155538983","https://openalex.org/W2164065816","https://openalex.org/W2164417576","https://openalex.org/W2166046424","https://openalex.org/W2168640335","https://openalex.org/W2171348543","https://openalex.org/W2171873547","https://openalex.org/W2317804643","https://openalex.org/W2335432880","https://openalex.org/W2412428681","https://openalex.org/W2494194360","https://openalex.org/W2734291336","https://openalex.org/W4313197481"],"related_works":["https://openalex.org/W2721677731","https://openalex.org/W3145446355","https://openalex.org/W615342635","https://openalex.org/W2527665174","https://openalex.org/W2290190495","https://openalex.org/W2055866077","https://openalex.org/W838749120","https://openalex.org/W7044036776","https://openalex.org/W1531866160","https://openalex.org/W43683727"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}