{"id":"https://openalex.org/W104959969","doi":null,"title":"Secretory IgA and IgM antibodies to E. coli O and poliovirus type I antigens occur in amniotic fluid, meconium and saliva from newborns. A neonatal immune response without antigenic exposure: a result of anti-idiotypic induction?","display_name":"Secretory IgA and IgM antibodies to E. coli O and poliovirus type I antigens occur in amniotic fluid, meconium and saliva from newborns. A neonatal immune response without antigenic exposure: a result of anti-idiotypic induction?","publication_year":1986,"publication_date":"1986-03-01","ids":{"openalex":"https://openalex.org/W104959969","mag":"104959969","pmid":"https://pubmed.ncbi.nlm.nih.gov/3011325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577556"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1577556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577556","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577556","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004802769","display_name":"Lotta Mellander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Mellander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057509274","display_name":"Barbro Carlsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Carlsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109924160","display_name":"Lars \u00c5ke Hanson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L A Hanson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8662,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.85946826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"63","issue":"3","first_page":"555","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.2827000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.2827000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.1923000067472458,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.12430000305175781,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-iga","display_name":"secretory IgA","score":0.9959999918937683},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neonatal-immunity","display_name":"neonatal immunity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/amniotic-fluid","display_name":"amniotic fluid","score":0.8669999837875366},{"id":"https://openalex.org/keywords/meconium","display_name":"meconium","score":1.0},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.9639999866485596},{"id":"https://openalex.org/keywords/poliovirus-type-1","display_name":"poliovirus type 1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/anti-idiotypic-antibodies","display_name":"anti-idiotypic antibodies","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hypogammaglobulinemia","display_name":"hypogammaglobulinemia","score":0.8550000190734863},{"id":"https://openalex.org/keywords/maternal-antibodies","display_name":"maternal antibodies","score":0.4090000092983246},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7032738924026489},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.7007936239242554},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6723442673683167},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6569153666496277},{"id":"https://openalex.org/C2778194526","wikidata":"https://www.wikidata.org/wiki/Q901674","display_name":"Amniotic fluid","level":4,"score":0.6551156044006348},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.5091208815574646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49560844898223877},{"id":"https://openalex.org/C2779631682","wikidata":"https://www.wikidata.org/wiki/Q12438936","display_name":"Poliovirus","level":3,"score":0.4841928780078888},{"id":"https://openalex.org/C2780985857","wikidata":"https://www.wikidata.org/wiki/Q937557","display_name":"Meconium","level":4,"score":0.4806043803691864},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47353169322013855},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.4593191146850586},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39769577980041504},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3648001253604889},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.34873807430267334},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.30676814913749695},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.23818036913871765},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.15237000584602356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000653","descriptor_name":"Amniotic Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007071","descriptor_name":"Immunoglobulin A, Secretory","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008470","descriptor_name":"Meconium","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017955","descriptor_name":"Poliovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1577556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577556","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:3011325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3011325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:104959969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3011325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1577556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577556","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1498086940","https://openalex.org/W1506591137","https://openalex.org/W1834498209","https://openalex.org/W1955350586","https://openalex.org/W1983085880","https://openalex.org/W2016124749","https://openalex.org/W2026822635","https://openalex.org/W2027616724","https://openalex.org/W2061649309","https://openalex.org/W2072191751","https://openalex.org/W2084728902","https://openalex.org/W2094337976","https://openalex.org/W2102588236","https://openalex.org/W2164763143","https://openalex.org/W2257823050","https://openalex.org/W2327168319","https://openalex.org/W2404479585","https://openalex.org/W3161349648","https://openalex.org/W4313310074","https://openalex.org/W4313376309"],"related_works":["https://openalex.org/W2144916751","https://openalex.org/W2084713882","https://openalex.org/W7026798383","https://openalex.org/W2058235033","https://openalex.org/W2047512446","https://openalex.org/W579898667","https://openalex.org/W1994772452","https://openalex.org/W2026822635","https://openalex.org/W2016124749","https://openalex.org/W2084076624"],"abstract_inverted_index":{"Antibodies":[0],"to":[1,38,82,140],"E.":[2,39,83],"coli":[3,40,84],"O-antigens":[4],"and":[5,25,29,35,41,79,85,110,156],"poliovirus":[6,42,86],"type":[7,87],"I":[8,88],"antigen":[9],"as":[10,12,48,50],"well":[11,49],"total":[13],"SIgA":[14,62,155],"were":[15,44],"analysed":[16],"using":[17],"enzyme-linked":[18],"immunosorbent":[19],"assay":[20],"(ELISA),":[21],"in":[22,26,46,51,66,90,126,145,160],"amniotic":[23,72],"fluid":[24],"meconium,":[27],"urine":[28],"saliva":[30,47],"from":[31,93,167],"neonates.":[32],"Secretory":[33],"IgA":[34,78,109],"IgM":[36,80,111,157],"antibodies":[37,81,124,158,166],"antigens":[43,89],"found":[45,159],"most":[52],"meconium":[53],"samples":[54,70,92],"taken":[55],"during":[56],"the":[57,122,127,135,151,154,161,168],"first":[58],"day":[59],"of":[60,69,76,96,121],"life.":[61],"could":[63,163],"be":[64,164],"quantified":[65],"all":[67],"types":[68],"including":[71],"fluid.":[73],"The":[74],"finding":[75],"secretory":[77,123],"early":[91],"an":[94],"infant":[95],"a":[97,114],"hypogammaglobulinaemic":[98],"mother,":[99],"given":[100],"regular":[101],"intravenous":[102],"(i.v.)":[103],"immunoglobulin":[104],"prophylaxis,":[105],"but":[106],"still":[107],"lacking":[108],"antibodies,":[112],"supports":[113],"fetal":[115],"origin":[116],"for":[117],"at":[118],"least":[119],"part":[120],"detected":[125],"different":[128],"samples.":[129],"Since":[130],"it":[131,147],"is":[132,143,148],"unlikely":[133],"that":[134,150],"fetus":[136],"has":[137],"been":[138],"exposed":[139],"poliovirus,":[141],"which":[142],"rare":[144],"Sweden,":[146],"hypothesized":[149],"stimulus":[152],"inducing":[153],"neonate":[162],"anti-idiotypic":[165],"mother.":[169]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}