{"id":"https://openalex.org/W104895035","doi":"https://doi.org/10.1042/bj2270833","title":"Assimilation of \u03b1-glutamyl-peptides by human erythrocytes. A possible means of glutamate supply for glutathione synthesis","display_name":"Assimilation of \u03b1-glutamyl-peptides by human erythrocytes. A possible means of glutamate supply for glutathione synthesis","publication_year":1985,"publication_date":"1985-05-01","ids":{"openalex":"https://openalex.org/W104895035","doi":"https://doi.org/10.1042/bj2270833","mag":"104895035","pmid":"https://pubmed.ncbi.nlm.nih.gov/2860897","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1144912"},"language":"en","primary_location":{"id":"doi:10.1042/bj2270833","doi":"https://doi.org/10.1042/bj2270833","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2270833","pdf_url":"https://portlandpress.com/biochemj/article-pdf/227/3/833/584758/bj2270833.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/227/3/833/584758/bj2270833.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005178664","display_name":"Glenn F. King","orcid":"https://orcid.org/0000-0002-2308-2200","observed_orcids":["https://orcid.org/0000-0002-2308-2200"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"G F King","raw_affiliation_strings":["Department of Biochemistry, University of Sydney, Sydney, N.S. W. 2006, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Sydney, Sydney, N.S. W. 2006, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081563103","display_name":"Philip W. Kuchel","orcid":"https://orcid.org/0000-0003-4100-7332","observed_orcids":["https://orcid.org/0000-0003-4100-7332"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"P W Kuchel","raw_affiliation_strings":["Department of Biochemistry, University of Sydney, Sydney, N.S. W. 2006, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Sydney, Sydney, N.S. W. 2006, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":null,"apc_paid":null,"fwci":2.6181,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.89134653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"227","issue":"3","first_page":"833","last_page":"842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.24729999899864197,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.5830000042915344},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/peptide-hydrolysis","display_name":"peptide hydrolysis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/glutaminase","display_name":"glutaminase","score":0.7329999804496765},{"id":"https://openalex.org/keywords/transmembrane-flux","display_name":"transmembrane flux","score":0.6480000019073486},{"id":"https://openalex.org/keywords/erythrocyte-membrane-permeability","display_name":"erythrocyte membrane permeability","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6750028729438782},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6583036184310913},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5477131009101868},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.542602002620697},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5327361226081848},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.5273224711418152},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5068195462226868},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48961836099624634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4651435613632202},{"id":"https://openalex.org/C156310829","wikidata":"https://www.wikidata.org/wiki/Q14913170","display_name":"Glutamate aspartate transporter","level":5,"score":0.4637826681137085},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3203526735305786},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.197890043258667},{"id":"https://openalex.org/C113657865","wikidata":"https://www.wikidata.org/wiki/Q5419641","display_name":"Excitatory amino-acid transporter","level":4,"score":0.07693791389465332},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005972","descriptor_name":"Glutaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj2270833","doi":"https://doi.org/10.1042/bj2270833","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2270833","pdf_url":"https://portlandpress.com/biochemj/article-pdf/227/3/833/584758/bj2270833.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1144912","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1144912","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:2860897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2860897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj2270833","doi":"https://doi.org/10.1042/bj2270833","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2270833","pdf_url":"https://portlandpress.com/biochemj/article-pdf/227/3/833/584758/bj2270833.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.44999998807907104,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W104895035.pdf","grobid_xml":"https://content.openalex.org/works/W104895035.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W19342487","https://openalex.org/W59490061","https://openalex.org/W103460356","https://openalex.org/W109933903","https://openalex.org/W1507958108","https://openalex.org/W1557083390","https://openalex.org/W1606738597","https://openalex.org/W1972114326","https://openalex.org/W1982625887","https://openalex.org/W1994695680","https://openalex.org/W1996509361","https://openalex.org/W2022449025","https://openalex.org/W2033141238","https://openalex.org/W2036226312","https://openalex.org/W2054131280","https://openalex.org/W2096731535","https://openalex.org/W2125668502","https://openalex.org/W2131311492","https://openalex.org/W2144550032","https://openalex.org/W2298256852","https://openalex.org/W2406347144","https://openalex.org/W2411831484","https://openalex.org/W2414067309","https://openalex.org/W2434340662","https://openalex.org/W2560725798","https://openalex.org/W4254731227"],"related_works":["https://openalex.org/W7095897922","https://openalex.org/W2147144307","https://openalex.org/W2043175458","https://openalex.org/W2575797342","https://openalex.org/W1575045349","https://openalex.org/W1606738597","https://openalex.org/W2014885497","https://openalex.org/W1972114326","https://openalex.org/W2418772587","https://openalex.org/W4409134337"],"abstract_inverted_index":{"Human":[0],"erythrocytes":[1],"are":[2,47,94],"essentially":[3],"impermeable":[4],"to":[5,71,87,141,260,279],"glutamate":[6,25,38,74,276],"and":[7,53,103,115,146,153,157,171,176,182,205,227,232,238],"yet":[8],"there":[9],"is":[10,27,285],"a":[11],"continual":[12],"requirement":[13],"for":[14,18,148,163,218,249],"the":[15,23,40,56,63,73,99,104,108,120,135,149,161,197,208,214,219,250,255,273,280],"amino":[16,101],"acid":[17],"glutathione":[19],"synthesis.":[20],"In":[21,193],"addition,":[22],"intracellular":[24],"concentration":[26],"approximately":[28],"five":[29],"times":[30],"that":[31,37,54,275],"of":[32,60,65,98,110,131,144,151,189,199,213,245],"plasma.":[33],"We":[34],"present":[35],"evidence":[36],"enters":[39],"red":[41],"cell":[42,117,159,195,281],"as":[43,282],"small":[44],"peptides":[45],"which":[46,284],"rapidly":[48],"hydrolysed":[49,287],"by":[50,207,288],"cytoplasmic":[51],"peptidase(s)":[52],"with":[55],"estimated":[57],"physiological":[58],"levels":[59],"plasma":[61],"glutamyl-peptides":[62],"rate":[64,198],"inward":[66],"flux":[67],"would":[68],"be":[69],"adequate":[70],"maintain":[72],"pool":[75],"at":[76],"its":[77],"observed":[78],"level.":[79],"Experimentally,":[80],"we":[81,258,271],"used":[82,140],"1H":[83],"spin-echo":[84,105],"n.m.r.":[85,256],"spectroscopy":[86],"follow":[88],"peptide":[89,92,200],"hydrolysis,":[90],"since":[91],"spectra":[93],"different":[95],"from":[96],"those":[97],"free":[100],"acids":[102],"sequence":[106],"enables":[107],"monitoring":[109],"reactions":[111],"in":[112,155,265],"concentrated":[113],"lysates":[114,156,164],"whole":[116,158,194,266],"suspensions.":[118],"Thus,":[119],"system":[121],"was":[122,139,202],"studied":[123],"under":[124],"near-physiological":[125],"conditions.":[126],"Weighted":[127],"non-linear":[128],"regression":[129],"analysis":[130],"progress":[132],"curves":[133],"using":[134],"integrated":[136],"Michaelis-Menten":[137],"equation":[138],"obtain":[142],"estimates":[143,212],"Km":[145,166],"Vmax.":[147,177,233],"hydrolysis":[150,201],"alpha-L-glutamyl-L-alanine":[152],"L-alanyl-alpha-L-glutamate":[154],"suspensions;":[160],"values":[162],"were":[165,221],"=":[167,178,223,234],"3.60":[168],"+/-":[169,173,180,184,225,229,236,240],"0.29":[170],"5.4":[172],"0.4":[174],"mmol/l":[175,231],"120":[179],"4":[181],"46.7":[183],"1.7":[185],"mmol/h":[186,242],"per":[187,243],"1":[188,244],"packed":[190,246],"cells":[191,247,267],"respectively.":[192],"suspensions":[196],"much":[203],"slower":[204],"dominated":[206],"transmembrane":[209],"flux-rate.":[210],"The":[211],"steady-state":[215],"kinetic":[216],"parameters":[217],"transport":[220],"Kt":[222],"2.35":[224],"0.41":[226],"11.2":[228],"1.0":[230],"3.26":[235],"0.13":[237],"19.7":[239],"0.7":[241],"respectively":[248],"previously":[251],"mentioned":[252],"peptides.":[253],"Using":[254],"procedure":[257],"failed":[259],"detect":[261],"any":[262],"glutaminase":[263],"activity":[264],"or":[268],"lysates;":[269],"thus,":[270],"exclude":[272],"possibility":[274],"gains":[277],"entry":[278],"glutamine":[283],"subsequently":[286],"glutaminase.":[289]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
