{"id":"https://openalex.org/W1045223643","doi":null,"title":"Effect of ginseng saponin, arsenic trioxide, beta-elemene combined with CTX on telomere-telomerase system in K562 cell line.","display_name":"Effect of ginseng saponin, arsenic trioxide, beta-elemene combined with CTX on telomere-telomerase system in K562 cell line.","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W1045223643","mag":"1045223643","pmid":"https://pubmed.ncbi.nlm.nih.gov/17204170"},"language":"en","primary_location":{"id":"pmid:17204170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17204170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002247862","display_name":"\u738b\u4e00","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Wang","raw_affiliation_strings":["Department of Hematology, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006759072","display_name":"\u65b9\u7f8e\u4e91","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei-Yun Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0961,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.43888448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"14","issue":"6","first_page":"1089","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ginsenosides","display_name":"ginsenosides","score":0.9639999866485596},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/beta-elemene","display_name":"\u03b2-elemene","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":1.0},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/erythroleukemia","display_name":"erythroleukemia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.7459999918937683},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/telomere-elongation","display_name":"telomere elongation","score":0.531000018119812},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.277285099029541}],"mesh":[{"descriptor_ui":"D000077237","descriptor_name":"Arsenic Trioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005894","descriptor_name":"Panax","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:17204170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17204170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"Journal Article"},{"id":"mag:1045223643","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/82963X/200606/23411820.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541720","display_name":"\u4e2d\u56fd\u5b9e\u9a8c\u8840\u6db2\u5b66\u6742\u5fd7","issn_l":"1009-2137","issn":["1009-2137"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u5b9e\u9a8c\u8840\u6db2\u5b66\u6742\u5fd7","raw_type":null},{"id":"mag:2367425765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17204170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1182784368","https://openalex.org/W2368842840","https://openalex.org/W2353324096","https://openalex.org/W1023953753","https://openalex.org/W1551413295","https://openalex.org/W851223611","https://openalex.org/W7026118543","https://openalex.org/W6998027940","https://openalex.org/W994059928","https://openalex.org/W2340916028"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,49,149,179,195,281],"aimed":[3],"to":[4,33],"investigate":[5],"the":[6,35,52,107,125,138,168,222,252,283],"modulating":[7],"effects":[8,80,121,232],"on":[9,167],"telomere":[10,174,193,284],"length":[11,68,141,175,194,285],"and":[12,32,38,61,69,76,89,116,140,160,170,218,224,259,270],"telomerase":[13,70,108,225,246,279,302],"activity":[14,71,109,134,226,247,280],"in":[15,27,239,274],"K562":[16,48,111,147,177,228,290],"cells":[17,112,148,178],"treated":[18],"by":[19,74,296],"arsenic":[20,99,155,214,266],"trioxide,":[21,100,156,215,267],"ginseng":[22,97,157,216,268],"saponin,":[23,98,158,217,269],"beta-elemene":[24,159,219,271],"alone":[25],"or":[26,102],"combination":[28,240,275],"with":[29,51,131,137,154,187,241,276],"cyclophosphamide":[30],"(CTX)":[31],"explore":[34],"possible":[36],"mechanism":[37],"new":[39],"therapy":[40],"for":[41,64,190],"acute":[42],"leukemia.":[43],"Human":[44],"erythroleukemic":[45],"cell":[46,291],"line":[47,292],"co-cultured":[50,153,186],"above-mentioned":[53],"drugs.":[54],"Cells":[55],"were":[56,72,84,122,129,233,237],"collected":[57],"after":[58,151],"24,":[59],"48":[60],"72":[62,191],"hours":[63],"further":[65],"detection.":[66],"Telomere":[67],"detected":[73],"Southern-blot":[75],"PCR-ELISA":[77],"respectively.":[78],"The":[79,92,119,162,230,243],"of":[81,110,142,146,164,176,204,227,245,251,254],"these":[82],"drugs":[83,128,189],"observed":[85],"at":[86,113],"different":[87],"concentrations":[88,115,139],"exposure":[90,117,171],"time.":[91,118,143,172],"results":[93],"showed":[94],"that":[95,203,213],"(1)":[96],"beta-elemene,":[101],"CTX":[103],"could":[104],"completely":[105],"inhibit":[106,221],"proper":[114],"inhibiting":[120,231],"enhanced":[123,234],"when":[124,235,265],"three":[126],"former":[127],"used":[130,238,273],"CTX.":[132,161,242,277],"Telomerase":[133],"decreased":[135,150],"proportionally":[136],"(2)":[144],"viability":[145],"being":[152,185],"level":[163],"inhibition":[165],"depends":[166],"concentration":[169],"(3)":[173],"5.36":[180],"+/-":[181],"0.18":[182],"kb.":[183],"After":[184],"those":[188],"hours,":[192],"5.90":[196],"kb":[197],"-6.50":[198],"kb,":[199],"significantly":[200],"longer":[201],"than":[202,301],"control":[205],"(5.18":[206],"-":[207],"5.35":[208],"kb).":[209],"It":[210],"is":[211],"concluded":[212],"can":[220,262],"growth":[223],"cells.":[229],"they":[236],"depression":[244],"may":[248,293],"be":[249,263],"one":[250],"mechanisms":[253],"anti-tumor":[255],"effect.":[256],"Less":[257],"dosage":[258],"shorter":[260],"course":[261],"expected":[264],"are":[272],"When":[278],"depressed,":[282],"prolonged":[286],"a":[287],"little,":[288],"indicating":[289],"extend":[294],"telomeres":[295],"some":[297],"alternative":[298],"way":[299],"other":[300],"activation.":[303]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}