{"id":"https://openalex.org/W104336579","doi":null,"title":"Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression.","display_name":"Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression.","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W104336579","mag":"104336579","pmid":"https://pubmed.ncbi.nlm.nih.gov/12646996"},"language":"en","primary_location":{"id":"pmid:12646996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12646996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian journal of andrology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cqvip.com/QK/84127X/200301/7884499.html","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075803791","display_name":"Jiro Kanaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jiro Kanaya","raw_affiliation_strings":["Department of Urology, Kanazawa University Graduate School of Medical Science, 15-1 Takarama-machi, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kanazawa University Graduate School of Medical Science, 15-1 Takarama-machi, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088064997","display_name":"Mitsuhiro Takashima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuhiro Takashima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108612355","display_name":"Eitetsu Koh","orcid":"https://orcid.org/0009-0004-8983-9239","observed_orcids":["https://orcid.org/0009-0004-8983-9239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eitetsu Koh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108468568","display_name":"Mikio Namiki","orcid":"https://orcid.org/0000-0002-0415-650X","observed_orcids":["https://orcid.org/0000-0002-0415-650X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikio Namiki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4793,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.5854549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"5","issue":"1","first_page":"9","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-independent-growth","display_name":"androgen-independent growth","score":0.8830000162124634},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ugt2b15","display_name":"UGT2B15","score":0.9629999995231628},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/antisense-cdna","display_name":"antisense cDNA","score":0.6589999794960022},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.982621431350708},{"id":"https://openalex.org/C2779907587","wikidata":"https://www.wikidata.org/wiki/Q14901439","display_name":"Glucuronidation","level":4,"score":0.6992305517196655},{"id":"https://openalex.org/C2781278898","wikidata":"https://www.wikidata.org/wiki/Q419543","display_name":"Glucuronosyltransferase","level":4,"score":0.6676371097564697},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6355810165405273},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5853363275527954},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5843042731285095},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5699347257614136},{"id":"https://openalex.org/C2778152042","wikidata":"https://www.wikidata.org/wiki/Q412593","display_name":"Uridine diphosphate","level":3,"score":0.4858998656272888},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.48413094878196716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48398637771606445},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4644128978252411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38978061079978943},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22191911935806274},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21042907238006592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19397565722465515},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17616182565689087},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14141401648521423},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.12317955493927002},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06481370329856873}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016373","descriptor_name":"DNA, Antisense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12646996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12646996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian journal of andrology","raw_type":"Journal Article"},{"id":"mag:104336579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12646996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:1549505748","doi":null,"is_oa":true,"landing_page_url":"http://www.cqvip.com/QK/84127X/200301/7884499.html","pdf_url":null,"source":{"id":"https://openalex.org/S78604184","display_name":"Asian Journal of Andrology","issn_l":"1008-682X","issn":["1008-682X","1745-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e9a\u6d32\u7537\u6027\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"mag:1549505748","doi":null,"is_oa":true,"landing_page_url":"http://www.cqvip.com/QK/84127X/200301/7884499.html","pdf_url":null,"source":{"id":"https://openalex.org/S78604184","display_name":"Asian Journal of Andrology","issn_l":"1008-682X","issn":["1008-682X","1745-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e9a\u6d32\u7537\u6027\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974610885","https://openalex.org/W2438847376","https://openalex.org/W2126040395","https://openalex.org/W1999416953","https://openalex.org/W2783768189","https://openalex.org/W2077257393","https://openalex.org/W2539426355","https://openalex.org/W2125822435","https://openalex.org/W4229542805","https://openalex.org/W2140725200"],"abstract_inverted_index":{"AIM:":[0],"To":[1,24],"investigate":[2],"the":[3,18,40,95,107,132],"mechanism":[4],"of":[5,8,20,50,82,110,118,134],"androgen-independent":[6,26],"growth":[7,27,133],"prostate":[9,29,136],"cancer":[10,30],"after":[11],"androgen":[12],"ablation":[13],"in":[14,28,36,70,106,112,121,131],"LNCaP":[15,83,87],"cells":[16,41,123],"and":[17,39,61,72,88],"effect":[19],"glucuronidation":[21,45,74,108],"activity.":[22,46],"METHODS:":[23],"establish":[25],"LNCaP-SF,":[31],"continuous":[32],"passage":[33],"was":[34,58],"performed":[35],"androgen-stripped":[37],"medium":[38],"were":[42,92],"evaluated":[43],"for":[44],"The":[47,116],"expression":[48,69,120],"vector":[49],"antisense":[51,96],"uridine":[52],"diphosphate":[53],"glucuronosyl-transferase":[54],"(UGT)":[55],"2B15":[56],"cDNA":[57],"also":[59],"constructed":[60],"evaluated.":[62],"RESULTS:":[63],"LNCaP-SF":[64,89,122],"lead":[65],"to":[66],"a":[67,127],"higher":[68,79],"UGT2B15":[71,97,101,119],"their":[73],"activity":[75,109],"is":[76,124],"2.5":[77],"times":[78],"than":[80,90],"that":[81,100],"cells.":[84,114],"Significantly":[85],"fewer":[86],"control":[91],"transfected":[93],"with":[94],"cDNA,":[98],"suggesting":[99],"plays":[102],"an":[103],"important":[104],"part":[105],"androgens":[111],"both":[113],"CONCLUSION:":[115],"alteration":[117],"proposed":[125],"as":[126],"biological":[128],"characteristic":[129],"involved":[130],"hormone-refractory":[135],"cancer.":[137]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}