{"id":"https://openalex.org/W104257086","doi":null,"title":"Target-effector interaction in the natural killer (NK) cell system. VI. The influence of age and genotype on NK binding characteristics.","display_name":"Target-effector interaction in the natural killer (NK) cell system. VI. The influence of age and genotype on NK binding characteristics.","publication_year":1980,"publication_date":"1980-10-01","ids":{"openalex":"https://openalex.org/W104257086","mag":"104257086","pmid":"https://pubmed.ncbi.nlm.nih.gov/7439938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1458190"},"language":"en","primary_location":{"id":"pmid:7439938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7439938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111715744","display_name":"John Roder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J C Roder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111715744"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4828,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.58197211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"2","first_page":"483","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nk-cell-receptors","display_name":"NK cell receptors","score":0.4880000054836273},{"id":"https://openalex.org/keywords/binding-avidity","display_name":"binding avidity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/ontogeny","display_name":"ontogeny","score":0.6809999942779541},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.9100000262260437},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.4729999899864197},{"id":"https://openalex.org/keywords/genotype-effects","display_name":"genotype effects","score":0.5820000171661377},{"id":"https://openalex.org/keywords/yeast-artificial-chromosomes","display_name":"yeast artificial chromosomes","score":0.5400000214576721},{"id":"https://openalex.org/keywords/nk-cell-maturation","display_name":"NK cell maturation","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C179223381","wikidata":"https://www.wikidata.org/wiki/Q419425","display_name":"Avidity","level":3,"score":0.6990899443626404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6394990682601929},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5938462018966675},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48899519443511963},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.47679972648620605},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.47108137607574463},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.43262019753456116},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4226277470588684},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42156368494033813},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.415759414434433},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37985724210739136},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30526819825172424},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22741270065307617},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.20000016689300537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1977231204509735},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.17637354135513306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1648608148097992},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1387878954410553},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008805","descriptor_name":"Mice, Inbred A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7439938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7439938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:104257086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7439938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1482804511","https://openalex.org/W1520282773","https://openalex.org/W1993319836","https://openalex.org/W2027115443","https://openalex.org/W2047039569","https://openalex.org/W2087092024","https://openalex.org/W2129278872","https://openalex.org/W2144931720","https://openalex.org/W2153735036","https://openalex.org/W4313307102"],"related_works":["https://openalex.org/W2065566971","https://openalex.org/W2047039569","https://openalex.org/W2028106548","https://openalex.org/W2087092024","https://openalex.org/W1562148296","https://openalex.org/W1599119377","https://openalex.org/W2079693752","https://openalex.org/W2885873367","https://openalex.org/W2033252622","https://openalex.org/W2306970539"],"abstract_inverted_index":{"Four":[0],"independent":[1],"assays":[2],"were":[3,29,41,53,70,89],"used":[4,47,54],"to":[5,55,101,117,163,178],"compare":[6],"target-cell":[7],"binding":[8,104],"by":[9,37,72],"NK":[10,38,96,109,131,141,150,159,176],"cells":[11,27,39,88,97,151,160],"in":[12,31,48,84,108,120,136,165],"different":[13],"populations.":[14],"First,":[15],"detergent":[16],"solubilized":[17],"and":[18,46,81,128,154],"reduced":[19],"proteins":[20],"from":[21,43],"the":[22,44,57,106,166,174],"surface":[23],"of":[24,59,65,76,125,158,182],"Moloney":[25],"lymphoma":[26],"(YAC)":[28],"electrophoresed":[30],"SDS-polyacrylamide":[32],"gels.":[33],"The":[34,92],"glycoproteins":[35],"recognized":[36],"(NK-TS)":[40],"eluted":[42],"gels":[45],"semi-quantitative":[49],"absorption":[50,148],"studies":[51,83],"or":[52],"inhibit":[56],"formation":[58],"target-effector":[60],"conjugates":[61],"as":[62],"an":[63],"estimate":[64],"relative":[66,146,156],"avidity.":[67],"These":[68,170],"findings":[69],"supported":[71],"a":[73,118],"comparative":[74],"analysis":[75],"cold":[77],"target":[78,87],"competition":[79],"curves":[80],"saturation":[82],"which":[85],"51Cr-labelled":[86],"carefully":[90],"titrated.":[91],"results":[93,171],"suggest":[94,172],"that":[95,135,164,173],"'mature'":[98],"during":[99,111],"ontogeny":[100],"higher":[102],"avidity":[103,157],"whereas":[105],"decline":[107],"function":[110],"senescence":[112],"can":[113],"solely":[114],"be":[115,181],"attributed":[116],"decrease":[119],"population":[121],"size.":[122],"A":[123],"comparison":[124],"high":[126,167],"(CBA)":[127],"low":[129,137],"(A/Sn)":[130],"reactive":[132],"strains":[133],"revealed":[134],"responder":[138,168],"(i)":[139],"absolute":[140],"frequency":[142],"was":[143,152,161],"decreased,":[144],"(ii)":[145],"NK-TS":[147],"per":[149],"low,":[153],"(iii)":[155],"identical":[162],"strain.":[169],"putative":[175],"receptor":[177],"YAC":[179],"may":[180],"restricted":[183],"heterogeneity.":[184]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}