{"id":"https://openalex.org/W1040259658","doi":null,"title":"Sequential translocation of tyrosine kinases Lyn and Syk to the activated Fcgamma receptors during phagocytosis.","display_name":"Sequential translocation of tyrosine kinases Lyn and Syk to the activated Fcgamma receptors during phagocytosis.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W1040259658","mag":"1040259658","pmid":"https://pubmed.ncbi.nlm.nih.gov/12056610"},"language":"en","primary_location":{"id":"pmid:12056610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12056610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091515581","display_name":"Agnieszka Strzelecka\u2010Kiliszek","orcid":"https://orcid.org/0000-0001-8112-8548","observed_orcids":["https://orcid.org/0000-0001-8112-8548"]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"A Strzelecka-Kiliszek","raw_affiliation_strings":["Department of Cell Biology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw. aslibra@nencki.gov.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw. aslibra@nencki.gov.pl","institution_ids":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035574500","display_name":"Andrzej Sobota","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Sobota","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1054,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.42324049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"40","issue":"2","first_page":"131","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.7279999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.7279999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.07890000194311142,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.04320000112056732,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lyn-kinase","display_name":"Lyn kinase","score":0.8240000009536743},{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.996999979019165},{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8970000147819519},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.8080000281333923},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.8320000171661377},{"id":"https://openalex.org/keywords/receptor-signaling-complex","display_name":"receptor signaling complex","score":0.43799999356269836},{"id":"https://openalex.org/keywords/particle-uptake","display_name":"particle uptake","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.9800817370414734},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.963829755783081},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.7725014686584473},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6500992178916931},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.6389617919921875},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.6287636756896973},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.601250171661377},{"id":"https://openalex.org/C183141693","wikidata":"https://www.wikidata.org/wiki/Q5005962","display_name":"Tyrosine-protein kinase CSK","level":5,"score":0.5755323171615601},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5537713766098022},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.5516388416290283},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5458716154098511},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5012941360473633},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49309465289115906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4290214478969574},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.41663622856140137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38659292459487915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3752972185611725},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.251788854598999}],"mesh":[{"descriptor_ui":"D000072377","descriptor_name":"Syk Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12056610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12056610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Journal Article"},{"id":"mag:1040259658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12056610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1552779466","https://openalex.org/W2029781087","https://openalex.org/W2133118708","https://openalex.org/W7097544376","https://openalex.org/W4312243655","https://openalex.org/W1920180399","https://openalex.org/W2009481807","https://openalex.org/W1545383294","https://openalex.org/W2155465613","https://openalex.org/W2156539075"],"abstract_inverted_index":{"Tyrosine":[0],"phosphorylation":[1,45],"of":[2,7,25,78,86,93,108,126],"numerous":[3,30],"proteins":[4,37,116],"is":[5,46,50,63,120],"one":[6],"the":[8,23,36,64,104,109],"earliest":[9],"events":[10],"detectable":[11],"during":[12],"Fcgamma":[13,94,118],"receptor-mediated":[14],"phagocytosis.":[15,87],"We":[16],"demonstrate":[17],"that":[18,91],"IgG-coated":[19],"particles":[20,42],"associated":[21,40,67],"with":[22,29,41,68,117],"surface":[24],"macrophages":[26],"are":[27,38],"enriched":[28],"tyrosine-phosphorylated":[31],"proteins.":[32],"During":[33],"particle":[34,54,130],"internalization":[35,57],"still":[39],"but":[43],"their":[44],"reduced.":[47],"Lyn":[48,79,97],"kinase":[49,62,66,101],"phosphorylated":[51,60,115],"both":[52],"at":[53,83],"binding":[55],"and":[56,75,80,102,111,129],"steps.":[58],"The":[59],"Syk":[61,81,100],"major":[65],"engulfed":[69],"particles.":[70],"Imnunofluorescent":[71],"studies":[72],"confirm":[73],"spatial":[74],"temporal":[76],"distribution":[77],"kinases":[82,110],"different":[84],"stages":[85],"Our":[88],"data":[89],"indicate":[90],"ligation":[92],"receptors":[95,119],"activates":[96],"followed":[98],"by":[99],"in":[103],"result":[105],"multimolecular":[106],"complex":[107],"several":[112],"accompanying":[113],"tyrosine":[114],"organized":[121],"leading":[122],"to":[123],"local":[124],"reorganization":[125],"actin-based":[127],"skeleton":[128],"uptake.":[131]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
