{"id":"https://openalex.org/W1040190103","doi":null,"title":"Granulocyte colony-stimulating factor-producing undifferentiated carcinoma of the colon mimicking a pulmonary giant cell carcinoma: a case showing overexpression of CD44 along with highly proliferating nestin-positive tumor vessels.","display_name":"Granulocyte colony-stimulating factor-producing undifferentiated carcinoma of the colon mimicking a pulmonary giant cell carcinoma: a case showing overexpression of CD44 along with highly proliferating nestin-positive tumor vessels.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1040190103","mag":"1040190103","pmid":"https://pubmed.ncbi.nlm.nih.gov/25400792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4230158"},"language":"en","primary_location":{"id":"pmid:25400792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25400792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4230158/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102229097","display_name":"Shogo Tajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111574","display_name":"Shizuoka Saiseikai General Hospital","ror":"https://ror.org/01s4cx283","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111574"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shogo Tajima","raw_affiliation_strings":["Department of Pathology, Shizuoka Saiseikai General Hospital Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shizuoka Saiseikai General Hospital Shizuoka, Japan","institution_ids":["https://openalex.org/I4210111574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047027677","display_name":"Michihiko Waki","orcid":"https://orcid.org/0000-0002-3754-9780","observed_orcids":["https://orcid.org/0000-0002-3754-9780"]},"institutions":[{"id":"https://openalex.org/I3123035732","display_name":"Hamamatsu University School of Medicine","ror":"https://ror.org/00ndx3g44","country_code":"JP","type":"education","lineage":["https://openalex.org/I3123035732"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michihiko Waki","raw_affiliation_strings":["Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine Shizuoka, Japan","institution_ids":["https://openalex.org/I3123035732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112076027","display_name":"Tomonori Tsuchiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111574","display_name":"Shizuoka Saiseikai General Hospital","ror":"https://ror.org/01s4cx283","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111574"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonori Tsuchiya","raw_affiliation_strings":["Department of Surgery, Shizuoka Saiseikai General Hospital Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Shizuoka Saiseikai General Hospital Shizuoka, Japan","institution_ids":["https://openalex.org/I4210111574"]}]},{"author_position":"last","author":{"id":null,"display_name":"Shoji Hoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111574","display_name":"Shizuoka Saiseikai General Hospital","ror":"https://ror.org/01s4cx283","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111574"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoji Hoshi","raw_affiliation_strings":["Department of Pathology, Shizuoka Saiseikai General Hospital Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shizuoka Saiseikai General Hospital Shizuoka, Japan","institution_ids":["https://openalex.org/I4210111574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4914,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.64951484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"7","issue":"10","first_page":"7034","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9769999980926514},{"id":"https://openalex.org/keywords/g-csf-producing-tumor","display_name":"G-CSF-producing tumor","score":0.8240000009536743},{"id":"https://openalex.org/keywords/undifferentiated-carcinoma","display_name":"undifferentiated carcinoma","score":0.9210000038146973},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.6389999985694885},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.7110000252723694},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7260000109672546},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7699999809265137},{"id":"https://openalex.org/keywords/g-csf-receptor","display_name":"G-CSF receptor","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2777738006","wikidata":"https://www.wikidata.org/wiki/Q14906812","display_name":"Nestin","level":4,"score":0.7253783941268921},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6132605075836182},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.6086772084236145},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6056705713272095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5151190161705017},{"id":"https://openalex.org/C2778292851","wikidata":"https://www.wikidata.org/wiki/Q2562565","display_name":"Descending colon","level":3,"score":0.5104488134384155},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.49021226167678833},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.47525450587272644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32543009519577026},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25924575328826904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25725871324539185},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.22610676288604736},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.15771687030792236},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.07811230421066284},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.07064712047576904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003082","descriptor_name":"Colectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018286","descriptor_name":"Carcinoma, Giant Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064231","descriptor_name":"Nestin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:25400792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25400792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:4230158","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4230158/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:1040190103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25400792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4230158","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4230158/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W28926443","https://openalex.org/W1501181157","https://openalex.org/W1567802479","https://openalex.org/W1712715060","https://openalex.org/W1873369382","https://openalex.org/W1980168406","https://openalex.org/W1982354412","https://openalex.org/W1982912817","https://openalex.org/W1986189118","https://openalex.org/W1997309422","https://openalex.org/W1997785224","https://openalex.org/W2004935845","https://openalex.org/W2014737409","https://openalex.org/W2018357635","https://openalex.org/W2029852820","https://openalex.org/W2039850711","https://openalex.org/W2041070235","https://openalex.org/W2046208473","https://openalex.org/W2057370966","https://openalex.org/W2058601429","https://openalex.org/W2072081789","https://openalex.org/W2085362515","https://openalex.org/W2088986869","https://openalex.org/W2097046206","https://openalex.org/W2099735500","https://openalex.org/W2111387788","https://openalex.org/W2114146544","https://openalex.org/W2122496801","https://openalex.org/W2135384302","https://openalex.org/W2140948660","https://openalex.org/W2157177239","https://openalex.org/W2160229439","https://openalex.org/W2410515173","https://openalex.org/W2418343700"],"related_works":["https://openalex.org/W2041070235","https://openalex.org/W1567802479","https://openalex.org/W2099735500","https://openalex.org/W4407592948","https://openalex.org/W190921443","https://openalex.org/W2008577338","https://openalex.org/W2022427970","https://openalex.org/W3123153908","https://openalex.org/W3197835061","https://openalex.org/W3092746099"],"abstract_inverted_index":{"Granulocyte":[0],"colony-stimulating":[1],"factor":[2],"(G-CSF)-producing":[3],"tumors":[4],"are":[5,207],"known":[6],"for":[7],"their":[8],"aggressive":[9],"behavior.":[10],"Only":[11],"four":[12],"cases":[13],"of":[14,27,31,52,122,146,158,169,213],"G-CSF-producing":[15],"colorectal":[16],"carcinoma":[17,30,41],"have":[18],"been":[19],"previously":[20],"reported.":[21],"Herein,":[22],"we":[23],"present":[24],"a":[25,44,50,180],"case":[26],"an":[28],"undifferentiated":[29],"the":[32,58,69,97,140,167,192,211],"descending":[33,59],"colon":[34,60],"showing":[35],"G-CSF":[36,115,132,177,193],"production":[37],"and":[38,113,148,196],"giant":[39],"cell":[40,80,111],"morphology":[42],"in":[43,57,136,139],"93-year-old":[45],"woman.":[46],"A":[47],"tumor":[48,73,137,152,189],"with":[49,144,163],"diameter":[51],"80":[53],"mm":[54],"was":[55,66,75,83,100,134],"identified":[56],"via":[61,191],"computed":[62],"tomography.":[63],"Descending":[64],"colectomy":[65],"performed":[67],"involving":[68],"abdominal":[70],"wall":[71],"where":[72],"invasion":[74],"observed.":[76],"The":[77,118,154],"white":[78,109],"blood":[79,110],"count,":[81],"which":[82],"elevated":[84],"before":[85],"resection,":[86],"decreased":[87],"to":[88,187,209],"normal":[89],"levels":[90],"after":[91,104,127],"intervention.":[92],"However,":[93],"local":[94],"recurrence":[95],"at":[96],"resected":[98,141],"site":[99],"detected":[101,135],"39":[102],"days":[103,126],"surgery.":[105],"Upon":[106],"recurrence,":[107],"increased":[108],"counts":[112],"serum":[114],"were":[116],"seen.":[117],"patient":[119,160],"died":[120],"because":[121],"respiratory":[123],"failure":[124],"98":[125],"colectomy.":[128],"By":[129],"using":[130],"immunohistochemistry,":[131],"expression":[133,168],"cells":[138],"specimen,":[142],"along":[143],"overexpression":[145],"CD44":[147,195],"highly":[149],"proliferating":[150],"nestin-positive":[151],"vessels.":[153],"poor":[155,174],"clinical":[156],"outcome":[157],"this":[159],"is":[161],"consistent":[162],"previous":[164],"reports":[165],"that":[166],"these":[170,216],"three":[171,217],"molecules":[172],"predict":[173],"prognosis.":[175],"While":[176],"can":[178],"be":[179,200],"therapeutic":[181,203],"target":[182],"considering":[183],"its":[184],"auto/paracrine":[185],"function":[186],"induce":[188],"growth":[190],"receptor,":[194],"nestin":[197],"may":[198],"also":[199],"possible":[201],"candidate":[202],"targets.":[204],"Further":[205],"studies":[206],"required":[208],"assess":[210],"efficacy":[212],"treatments":[214],"targeting":[215],"molecules.":[218]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
