{"id":"https://openalex.org/W1037500466","doi":null,"title":"Protective effect of tubuloside B on TNFalpha-induced apoptosis in neuronal cells.","display_name":"Protective effect of tubuloside B on TNFalpha-induced apoptosis in neuronal cells.","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W1037500466","mag":"1037500466","pmid":"https://pubmed.ncbi.nlm.nih.gov/15456528"},"language":"en","primary_location":{"id":"pmid:15456528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15456528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080847800","display_name":"MinDENG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Deng","raw_affiliation_strings":["Research Center of Occupational Medicine, Peking University Third Hospital, Beijing 100083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Occupational Medicine, Peking University Third Hospital, Beijing 100083, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039833690","display_name":"Jin-yuanZHAO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin-Yuan Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060044303","display_name":"Xiao-dongJU","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Dong Ju","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084313401","display_name":"Peng-feiTU","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng-Fei Tu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043045275","display_name":"Yong-jiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039879766","display_name":"Zheng-binLI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zheng-Bin Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6832,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.59919077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"25","issue":"10","first_page":"1276","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.44679999351501465,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.44679999351501465,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.2639000117778778,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cistanche-salsa","display_name":"Cistanche salsa","score":0.9520000219345093},{"id":"https://openalex.org/keywords/phenylethanoids","display_name":"phenylethanoids","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.871999979019165},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9020000100135803},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7971495389938354},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6555972695350647},{"id":"https://openalex.org/C2778271344","wikidata":"https://www.wikidata.org/wiki/Q903395","display_name":"Agarose gel electrophoresis","level":3,"score":0.6388275623321533},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6249502897262573},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.6045646667480469},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.5841400623321533},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5055782794952393},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.46237847208976746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4559796452522278},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4369734823703766},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.436673641204834},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.4348088502883911},{"id":"https://openalex.org/C2778470358","wikidata":"https://www.wikidata.org/wiki/Q908761","display_name":"Fura-2","level":4,"score":0.4344456195831299},{"id":"https://openalex.org/C2779083432","wikidata":"https://www.wikidata.org/wiki/Q7390126","display_name":"SH-SY5Y","level":4,"score":0.4297100305557251},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4277965724468231},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.41648536920547485},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.41478633880615234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40344566106796265},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3830524682998657},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.36681342124938965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3065120577812195},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25327959656715393},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19175195693969727},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14144057035446167},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11079031229019165},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.05353248119354248},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D031671","descriptor_name":"Cistanche","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15456528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15456528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:1037500466","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/95561A/200410/11033554.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542255","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W135937383","https://openalex.org/W169111171","https://openalex.org/W253559036","https://openalex.org/W1535426243","https://openalex.org/W1540436551","https://openalex.org/W1566676785","https://openalex.org/W1571529930","https://openalex.org/W1818989087","https://openalex.org/W1832527043","https://openalex.org/W1969243118","https://openalex.org/W1972445264","https://openalex.org/W1978111359","https://openalex.org/W1989466994","https://openalex.org/W1999139720","https://openalex.org/W2009837270","https://openalex.org/W2017692041","https://openalex.org/W2021030855","https://openalex.org/W2029083682","https://openalex.org/W2042594494","https://openalex.org/W2054844344","https://openalex.org/W2057810394","https://openalex.org/W2058651055","https://openalex.org/W2061497413","https://openalex.org/W2063737330","https://openalex.org/W2088791795","https://openalex.org/W2117711594","https://openalex.org/W2120614140","https://openalex.org/W2129902275","https://openalex.org/W2130866079","https://openalex.org/W2136781825","https://openalex.org/W2170311610","https://openalex.org/W2170961323","https://openalex.org/W2298906034","https://openalex.org/W2409378878","https://openalex.org/W2412650393","https://openalex.org/W2442082896"],"related_works":["https://openalex.org/W2172079964","https://openalex.org/W2380809464","https://openalex.org/W1996492103","https://openalex.org/W2147657543","https://openalex.org/W7139116087","https://openalex.org/W7163568078","https://openalex.org/W1999304536","https://openalex.org/W2150627157","https://openalex.org/W2069333203","https://openalex.org/W2011123924"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"investigate":[2],"the":[3,11,15,73,86,187,224],"neuroprotective":[4,225],"effect":[5],"of":[6,10,17,56,66,80,88,122,136,150,193,205,209,211,217],"tubuloside":[7,176,194],"B,":[8],"one":[9],"phenylethanoids":[12],"isolated":[13],"from":[14],"stems":[16],"Cistanche":[18],"salsa,":[19],"on":[20,199],"tumor":[21],"necrosis":[22],"factor-alpha":[23],"(TNFalpha)-induced":[24],"apoptosis":[25,230],"in":[26,157,231,238],"SH-SY5Y":[27,108,232],"neuronal":[28],"cells.":[29],"METHODS:":[30],"Cell":[31],"viability":[32],"was":[33,58,70,196],"analyzed":[34],"using":[35,42],"MTT":[36],"assay.":[37],"Apoptotic":[38],"cells":[39,109,138,233],"were":[40,91,161],"detected":[41],"Hoechst33342":[43],"staining,":[44],"and":[45,50,85,153,155,163,215,234],"confirmed":[46],"by":[47,76,93,129,167],"DNA":[48,124],"fragmentation":[49],"flow":[51],"cytometric":[52],"analysis.":[53],"The":[54,64,78,133,190],"activity":[55,165],"caspase-3":[57,164,218],"measured":[59],"with":[60,72,100,111,147,171,175],"special":[61],"assay":[62],"kit.":[63],"concentration":[65,210],"free":[67,212],"intracellular":[68,81,151,213],"calcium":[69,214],"determined":[71,92],"probe":[74,102],"Indo-1":[75],"spectrometer.":[77],"level":[79],"reactive":[82],"oxygen":[83],"species":[84],"potential":[87,160],"mitochondrial":[89,158],"membrane":[90,159],"laser":[94],"scanning":[95],"confocal":[96],"microscopy":[97],"(LSCM)":[98],"combined":[99],"fluorescence":[101],"H2DCFDA":[103],"or":[104,180],"JC-1":[105],"respectively.":[106],"RESULTS:":[107],"treated":[110],"TNFalpha":[112],"100":[113,181],"microg/L":[114],"for":[115,183],"36":[116,144],"h":[117,145,185],"showed":[118],"typical":[119],"morphological":[120],"changes":[121],"apoptosis.":[123,189],"ladder":[125],"could":[126],"be":[127,236],"observed":[128],"agarose":[130],"gel":[131],"electrophoresis.":[132],"highest":[134],"percentage":[135],"apoptotic":[137],"accumulated":[139],"to":[140,227],"37.5":[141],"%.":[142],"Following":[143],"treatment":[146],"TNFalpha,":[148],"accumulation":[149],"ROS":[152],"[Ca2+]i":[154],"decrease":[156,208],"observed,":[162],"increased":[166],"about":[168],"five-fold":[169],"compared":[170],"controls.":[172],"However,":[173],"pretreatment":[174],"B":[177,195,222],"(1,":[178],"10,":[179],"mg/L)":[182],"2":[184],"attenuated":[186],"TNFalpha-mediated":[188],"antiapoptotic":[191],"action":[192],"partially":[197],"dependent":[198],"an":[200],"anti-oxidative":[201],"stress":[202],"effects,":[203],"maintain":[204],"mitochondria":[206],"function,":[207],"inhibition":[216],"activity.":[219],"CONCLUSION:":[220],"Tubuloside":[221],"has":[223],"capacity":[226],"antagonize":[228],"TNFalpha-induced":[229],"may":[235],"useful":[237],"treating":[239],"some":[240],"neurodegenerative":[241],"diseases.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
