{"id":"https://openalex.org/W103745993","doi":null,"title":"Crosstalk of cells in bone metastasis: Molecular and cellular analysis of the mutual effects of prostate cancer cells and osteoblasts","display_name":"Crosstalk of cells in bone metastasis: Molecular and cellular analysis of the mutual effects of prostate cancer cells and osteoblasts","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W103745993","mag":"103745993"},"language":"en","primary_location":{"id":"pmh:oai:kluedo.ub.rptu.de:2173","doi":null,"is_oa":false,"landing_page_url":"https://kluedo.ub.rptu.de/frontdoor/index/index/docId/2173","pdf_url":null,"source":{"id":"https://openalex.org/S4306402046","display_name":"Publication Server of Kaiserslautern University of Technology (Kaiserslautern University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153267046","host_organization_name":"University of Kaiserslautern","host_organization_lineage":["https://openalex.org/I153267046"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Agnieszka Ha\u0142a\u015b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Agnieszka Ha\u0142a\u015b","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.31450000405311584,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.31450000405311584,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.2969000041484833,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.19519999623298645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer-bone-metastasis","display_name":"prostate cancer bone metastasis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8100000023841858},{"id":"https://openalex.org/keywords/osteomimicry","display_name":"osteomimicry","score":0.9779999852180481},{"id":"https://openalex.org/keywords/il-6-signaling","display_name":"IL-6 signaling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/opg","display_name":"OPG","score":0.6970000267028809},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.9589999914169312},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cancer-stem-cell-niche","display_name":"cancer stem cell niche","score":0.781000018119812},{"id":"https://openalex.org/keywords/nppb","display_name":"NPPB","score":0.7870000004768372},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/bone-microenvironment","display_name":"bone microenvironment","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.7445952296257019},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6060597896575928},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.5915290117263794},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5827173590660095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5132689476013184},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5128374695777893},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5026774406433105},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4997682571411133},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4759376049041748},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.4711046814918518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4609307646751404},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.45071539282798767},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.42164599895477295},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4203081727027893},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38898470997810364},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22399011254310608},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.16857728362083435},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0827626883983612},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.06292590498924255},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:kluedo.ub.rptu.de:2173","doi":null,"is_oa":false,"landing_page_url":"https://kluedo.ub.rptu.de/frontdoor/index/index/docId/2173","pdf_url":null,"source":{"id":"https://openalex.org/S4306402046","display_name":"Publication Server of Kaiserslautern University of Technology (Kaiserslautern University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153267046","host_organization_name":"University of Kaiserslautern","host_organization_lineage":["https://openalex.org/I153267046"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},{"id":"pmh:oai:kluedo.ub.uni-kl.de:2173","doi":null,"is_oa":false,"landing_page_url":"https://kluedo.ub.uni-kl.de/frontdoor/index/index/docId/2173","pdf_url":null,"source":{"id":"https://openalex.org/S4306402046","display_name":"Publication Server of Kaiserslautern University of Technology (Kaiserslautern University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153267046","host_organization_name":"University of Kaiserslautern","host_organization_lineage":["https://openalex.org/I153267046"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralthesis"},{"id":"mag:103745993","doi":null,"is_oa":false,"landing_page_url":"https://kluedo.ub.uni-kl.de/files/2173/Halas_dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":262,"referenced_works":["https://openalex.org/W53596582","https://openalex.org/W113823410","https://openalex.org/W189593432","https://openalex.org/W1419228847","https://openalex.org/W1493004097","https://openalex.org/W1503388237","https://openalex.org/W1520425169","https://openalex.org/W1536763098","https://openalex.org/W1560201422","https://openalex.org/W1571232771","https://openalex.org/W1639450499","https://openalex.org/W1671698008","https://openalex.org/W1672290086","https://openalex.org/W1693984391","https://openalex.org/W1775749144","https://openalex.org/W1809966404","https://openalex.org/W1840163537","https://openalex.org/W1898988323","https://openalex.org/W1951412780","https://openalex.org/W1953156003","https://openalex.org/W1966970126","https://openalex.org/W1967402039","https://openalex.org/W1967456673","https://openalex.org/W1968223455","https://openalex.org/W1968428144","https://openalex.org/W1969323709","https://openalex.org/W1969670678","https://openalex.org/W1970228722","https://openalex.org/W1971707389","https://openalex.org/W1973879044","https://openalex.org/W1974444359","https://openalex.org/W1974659965","https://openalex.org/W1975025595","https://openalex.org/W1975244118","https://openalex.org/W1975319922","https://openalex.org/W1976329877","https://openalex.org/W1976454147","https://openalex.org/W1977453254","https://openalex.org/W1978146894","https://openalex.org/W1979090002","https://openalex.org/W1979153645","https://openalex.org/W1979472633","https://openalex.org/W1979847738","https://openalex.org/W1981003014","https://openalex.org/W1981401469","https://openalex.org/W1983663007","https://openalex.org/W1984539870","https://openalex.org/W1984673297","https://openalex.org/W1984804693","https://openalex.org/W1985422656","https://openalex.org/W1985760249","https://openalex.org/W1986207534","https://openalex.org/W1987317889","https://openalex.org/W1988616931","https://openalex.org/W1989803052","https://openalex.org/W1992514491","https://openalex.org/W1992933633","https://openalex.org/W1993083123","https://openalex.org/W1994195248","https://openalex.org/W1994417406","https://openalex.org/W1994596418","https://openalex.org/W1995789564","https://openalex.org/W1996058081","https://openalex.org/W1997286496","https://openalex.org/W1997374120","https://openalex.org/W1997829755","https://openalex.org/W1998276951","https://openalex.org/W1998696289","https://openalex.org/W1999178985","https://openalex.org/W1999352200","https://openalex.org/W2000595654","https://openalex.org/W2000906131","https://openalex.org/W2002821874","https://openalex.org/W2003843932","https://openalex.org/W2004337395","https://openalex.org/W2004363028","https://openalex.org/W2005360738","https://openalex.org/W2005472560","https://openalex.org/W2005566723","https://openalex.org/W2005841227","https://openalex.org/W2006250327","https://openalex.org/W2006511292","https://openalex.org/W2007264367","https://openalex.org/W2007897263","https://openalex.org/W2009017218","https://openalex.org/W2009750404","https://openalex.org/W2009896867","https://openalex.org/W2011311044","https://openalex.org/W2012038722","https://openalex.org/W2012672965","https://openalex.org/W2012691496","https://openalex.org/W2012804955","https://openalex.org/W2012884263","https://openalex.org/W2013953134","https://openalex.org/W2014006626","https://openalex.org/W2015192989","https://openalex.org/W2017557087","https://openalex.org/W2017757468","https://openalex.org/W2018142473","https://openalex.org/W2018446432","https://openalex.org/W2018836208","https://openalex.org/W2018918471","https://openalex.org/W2020285903","https://openalex.org/W2021276131","https://openalex.org/W2023106260","https://openalex.org/W2025314183","https://openalex.org/W2025962890","https://openalex.org/W2026898871","https://openalex.org/W2031883266","https://openalex.org/W2032394856","https://openalex.org/W2033059778","https://openalex.org/W2033210006","https://openalex.org/W2033438402","https://openalex.org/W2033890749","https://openalex.org/W2034779933","https://openalex.org/W2035321569","https://openalex.org/W2035356920","https://openalex.org/W2035653659","https://openalex.org/W2035857483","https://openalex.org/W2037499635","https://openalex.org/W2037943063","https://openalex.org/W2037949540","https://openalex.org/W2038036973","https://openalex.org/W2038675898","https://openalex.org/W2039215669","https://openalex.org/W2039748263","https://openalex.org/W2040002581","https://openalex.org/W2042839797","https://openalex.org/W2043103956","https://openalex.org/W2043536378","https://openalex.org/W2044742025","https://openalex.org/W2046018563","https://openalex.org/W2046675807","https://openalex.org/W2047588393","https://openalex.org/W2047902687","https://openalex.org/W2050902903","https://openalex.org/W2051528631","https://openalex.org/W2052052041","https://openalex.org/W2055489437","https://openalex.org/W2057360439","https://openalex.org/W2057477877","https://openalex.org/W2057888154","https://openalex.org/W2058053962","https://openalex.org/W2059085904","https://openalex.org/W2060086044","https://openalex.org/W2060719489","https://openalex.org/W2062276394","https://openalex.org/W2062706888","https://openalex.org/W2065184790","https://openalex.org/W2067590651","https://openalex.org/W2068627477","https://openalex.org/W2070291618","https://openalex.org/W2072772987","https://openalex.org/W2072925059","https://openalex.org/W2073788939","https://openalex.org/W2074494405","https://openalex.org/W2075760937","https://openalex.org/W2076261339","https://openalex.org/W2076704745","https://openalex.org/W2077958519","https://openalex.org/W2078419961","https://openalex.org/W2079932446","https://openalex.org/W2079934671","https://openalex.org/W2080908680","https://openalex.org/W2082575625","https://openalex.org/W2083337630","https://openalex.org/W2083933788","https://openalex.org/W2084102864","https://openalex.org/W2084604753","https://openalex.org/W2084913763","https://openalex.org/W2085747258","https://openalex.org/W2086008590","https://openalex.org/W2086320165","https://openalex.org/W2086477764","https://openalex.org/W2086840459","https://openalex.org/W2087324367","https://openalex.org/W2087472570","https://openalex.org/W2087504707","https://openalex.org/W2088357471","https://openalex.org/W2092230690","https://openalex.org/W2092543817","https://openalex.org/W2093571282","https://openalex.org/W2094885378","https://openalex.org/W2095494773","https://openalex.org/W2095994081","https://openalex.org/W2098347523","https://openalex.org/W2099368049","https://openalex.org/W2100837269","https://openalex.org/W2102085111","https://openalex.org/W2102174623","https://openalex.org/W2103023842","https://openalex.org/W2105738238","https://openalex.org/W2110149781","https://openalex.org/W2112736306","https://openalex.org/W2112981969","https://openalex.org/W2113949832","https://openalex.org/W2114162483","https://openalex.org/W2114394594","https://openalex.org/W2119962765","https://openalex.org/W2120372000","https://openalex.org/W2121778907","https://openalex.org/W2122450538","https://openalex.org/W2123306698","https://openalex.org/W2124281312","https://openalex.org/W2126482839","https://openalex.org/W2126990159","https://openalex.org/W2127107445","https://openalex.org/W2127360580","https://openalex.org/W2127393724","https://openalex.org/W2128473328","https://openalex.org/W2128827916","https://openalex.org/W2129063289","https://openalex.org/W2130687125","https://openalex.org/W2132655645","https://openalex.org/W2134024560","https://openalex.org/W2134812217","https://openalex.org/W2137676632","https://openalex.org/W2137958038","https://openalex.org/W2138120234","https://openalex.org/W2138143990","https://openalex.org/W2142820105","https://openalex.org/W2144206769","https://openalex.org/W2145269260","https://openalex.org/W2146965174","https://openalex.org/W2147745959","https://openalex.org/W2147844897","https://openalex.org/W2148454447","https://openalex.org/W2149218924","https://openalex.org/W2149244210","https://openalex.org/W2149861871","https://openalex.org/W2151313405","https://openalex.org/W2152770189","https://openalex.org/W2153382986","https://openalex.org/W2153720415","https://openalex.org/W2154568166","https://openalex.org/W2156106286","https://openalex.org/W2156717941","https://openalex.org/W2159590253","https://openalex.org/W2160042168","https://openalex.org/W2161949020","https://openalex.org/W2163341100","https://openalex.org/W2163745864","https://openalex.org/W2163995267","https://openalex.org/W2164042638","https://openalex.org/W2164448282","https://openalex.org/W2165580132","https://openalex.org/W2166159531","https://openalex.org/W2167030358","https://openalex.org/W2167184409","https://openalex.org/W2167288022","https://openalex.org/W2168490066","https://openalex.org/W2169062791","https://openalex.org/W2170595983","https://openalex.org/W2171466904","https://openalex.org/W2341456905","https://openalex.org/W2382205582","https://openalex.org/W2406679019","https://openalex.org/W2413001830","https://openalex.org/W2525468814","https://openalex.org/W2887937198","https://openalex.org/W3151307858","https://openalex.org/W3216705818"],"related_works":["https://openalex.org/W2167184409","https://openalex.org/W2053662837","https://openalex.org/W2059085904","https://openalex.org/W1163900701","https://openalex.org/W2171466904","https://openalex.org/W2018918471","https://openalex.org/W1989341512","https://openalex.org/W179236935","https://openalex.org/W4386523443","https://openalex.org/W2163745864"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,19,33,45,96,145,186,306,353],"preferentially":[2],"metastasizes":[3],"to":[4,86,131,147,155,181,212,358],"the":[5,15,71,87,99,132,140,171,182,253,262,273,277,284,333,341,346],"skeleton":[6],"and":[7,35,53,110,113,128,164,167,199,231,245,258,260,266,291,303,336,355],"abundant":[8],"evidence":[9],"exists":[10],"that":[11,84,178],"osteoblasts":[12,36,179,302,330,356],"specifically":[13],"support":[14],"metastatic":[16,153,321],"process,":[17],"including":[18,98],"stem":[20,293,337],"cell":[21,46,294],"niche":[22],"formation.":[23],"At":[24],"early":[25,122],"stages":[26],"of":[27,31,44,56,65,77,101,134,143,162,184,193,224,228,232,238,252,261,279,286,316,340,349],"bone":[28,73,289,318],"metastasis,":[29],"crosstalk":[30],"prostate":[32,95,144,185,305,322,352],"cells":[34,146,154,187,354],"through":[37],"soluble":[38],"molecules":[39,241,255],"results":[40,309],"in":[41,94,137,283,288,292,301,304,320,351],"a":[42,63,174,280],"decrease":[43],"proliferation,":[47,195],"accompanied":[48],"by":[49,221,328],"altered":[50],"adhesive":[51],"properties":[52,339],"increased":[54],"expression":[55,92,190,223],"bone-specific":[57],"genes,":[58],"or":[59],"osteomimicry.":[60],"Osteoblasts":[61],"synthesize":[62],"plethora":[64],"biologically":[66],"active":[67],"factors,":[68,149],"which":[69,150,203,268,329],"comprise":[70],"unique":[72],"microenvironment.":[74],"By":[75],"means":[76],"quantitative":[78],"real-time":[79],"RT-PCR":[80],"it":[81],"was":[82,216],"determined":[83],"exposure":[85],"osteoblast":[88,214,239,270],"secretome":[89,183],"induced":[90],"gene":[91,189],"changes":[93],"cells,":[97],"upregulation":[100,133,251],"osteomimetic":[102,158,335],"genes":[103],"such":[104,242],"as":[105,219,243,324,326],"BMP2,":[106,259],"AP,":[107],"COL1A1,":[108],"OPG":[109,135],"RANKL.":[111],"IL6":[112,127,166],"TGFbeta1":[114,129],"signaling":[115],"pathway":[116,229],"components":[117,230],"also":[118,247],"became":[119,296],"upregulated":[120,297],"at":[121],"time":[123],"points.":[124],"Moreover,":[125],"osteoblast-released":[126,148],"contributed":[130],"mRNA":[136,274],"LNCaP.":[138],"Thus,":[139],"earliest":[141],"response":[142],"ultimately":[151],"cause":[152],"assume":[156],"an":[157,311],"phenotype,":[159],"involved":[160],"activation":[161],"paracrine":[163],"autocrine":[165],"TGFbeta":[168,209],"signaling.":[169],"On":[170],"other":[172],"hand,":[173],"microarray":[175],"analysis":[176],"showed":[177],"exposed":[180],"exhibited":[188],"alterations":[191],"suggestive":[192],"repressed":[194],"decreased":[196],"matrix":[197],"synthesis":[198],"inhibited":[200],"immune":[201],"response,":[202],"together":[204],"indicate":[205],"enhanced":[206],"preosteocytic":[207],"differentiation.":[208,271],"signaling,":[210],"known":[211],"inhibit":[213],"maturation,":[215],"strongly":[217],"suppressed,":[218],"shown":[220],"elevated":[222],"negative":[225],"regulators,":[226],"downregulation":[227,237],"numerous":[233],"target":[234],"genes.":[235],"Transcriptional":[236],"inhibitory":[240],"DKK1":[244],"FST":[246],"occurred,":[248],"with":[249],"concomitant":[250],"osteoinductive":[254],"ADM,":[256],"STC1":[257],"transcription":[263],"factors":[264],"CBFA1":[265],"HES1,":[267],"promote":[269],"Finally,":[272],"encoding":[275],"NPPB,":[276],"precursor":[278],"molecule":[281],"implicated":[282],"inhibition":[285],"TGFbeta\uf020effects,":[287],"formation":[290,319],"maintenance,":[295],"after":[298],"coculture":[299],"both":[300],"cells.":[307,343],"These":[308],"provide":[310],"insight":[312],"into":[313],"potential":[314],"mechanisms":[315,327],"dysregulated":[317],"cancer,":[323],"well":[325],"might":[331],"enhance":[332],"invasive,":[334],"cell-like":[338],"tumor":[342],"In":[344],"particular,":[345],"differential":[347],"modulation":[348],"TGFbeta\uf020signaling":[350],"appears":[357],"merit":[359],"further":[360],"research.":[361]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
