{"id":"https://openalex.org/W103575209","doi":null,"title":"Arachidonic acid metabolism in human trabecular meshwork cells.","display_name":"Arachidonic acid metabolism in human trabecular meshwork cells.","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W103575209","mag":"103575209","pmid":"https://pubmed.ncbi.nlm.nih.gov/3141310"},"language":"en","primary_location":{"id":"pmid:3141310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3141310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043994887","display_name":"Robert Neal Weinreb","orcid":"https://orcid.org/0000-0001-9553-3202","observed_orcids":["https://orcid.org/0000-0001-9553-3202","https://orcid.org/0000-0003-4217-4853"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R N Weinreb","raw_affiliation_strings":["Department of Ophthalmology, University of California, San Diego, La Jolla 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of California, San Diego, La Jolla 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110033520","display_name":"Jon R. Polansky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Polansky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062409605","display_name":"Jorge A. Alvarado","orcid":"https://orcid.org/0000-0002-1677-361X","observed_orcids":["https://orcid.org/0000-0002-1677-361X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Alvarado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060812724","display_name":"Murray David Mitchell","orcid":"https://orcid.org/0000-0002-6167-7176","observed_orcids":["https://orcid.org/0000-0002-6167-7176"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M D Mitchell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4352,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.48169782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"29","issue":"11","first_page":"1708","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.1298999935388565,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":1.0},{"id":"https://openalex.org/keywords/human-trabecular-meshwork-cells","display_name":"human trabecular meshwork cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/prostaglandin-f2alpha","display_name":"prostaglandin F2alpha","score":0.9279999732971191},{"id":"https://openalex.org/keywords/6-keto-prostaglandin-f1-alpha","display_name":"6-keto-prostaglandin F1alpha","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lipoxygenase-pathway","display_name":"lipoxygenase pathway","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hydroxyeicosatetraenoic-acids","display_name":"hydroxyeicosatetraenoic acids","score":0.9459999799728394},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.9819999933242798},{"id":"https://openalex.org/keywords/aqueous-humor-outflow","display_name":"aqueous humor outflow","score":0.9290000200271606},{"id":"https://openalex.org/keywords/bw755c","display_name":"BW755C","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9070000052452087},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.835496187210083},{"id":"https://openalex.org/C2781121420","wikidata":"https://www.wikidata.org/wiki/Q750873","display_name":"Trabecular meshwork","level":3,"score":0.7137278914451599},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.680801272392273},{"id":"https://openalex.org/C2776685179","wikidata":"https://www.wikidata.org/wiki/Q2704449","display_name":"Leukotriene B4","level":3,"score":0.616182804107666},{"id":"https://openalex.org/C2779630222","wikidata":"https://www.wikidata.org/wiki/Q65658502","display_name":"Hydroxyeicosatetraenoic acid","level":4,"score":0.5399075150489807},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5333155393600464},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5256199240684509},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5166866779327393},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4891720116138458},{"id":"https://openalex.org/C2776352991","wikidata":"https://www.wikidata.org/wiki/Q407680","display_name":"Eicosanoid","level":4,"score":0.4583929777145386},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.44920292496681213},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.4447427988052368},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44455039501190186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42008838057518005},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4156973361968994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3541710376739502},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16292905807495117},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1318962574005127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08917418122291565},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3141310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3141310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:103575209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3141310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W192960299","https://openalex.org/W989142126","https://openalex.org/W2413307264"],"related_works":["https://openalex.org/W2400800535","https://openalex.org/W1964893045","https://openalex.org/W193600061","https://openalex.org/W2054904872","https://openalex.org/W1966244893","https://openalex.org/W2121216118","https://openalex.org/W1985153176","https://openalex.org/W2122026500","https://openalex.org/W2069429896","https://openalex.org/W1487824760"],"abstract_inverted_index":{"Prostaglandins":[0],"and":[1,12,54,129,137,156,171],"other":[2],"eicosanoids":[3,37],"in":[4,15,38,81,91,149],"the":[5,16,21,34,77,82,92,100,112,121],"trabecular":[6,41],"meshwork":[7,42],"may":[8],"play":[9],"important":[10,31],"physiological":[11],"pharmacological":[13],"roles":[14],"aqueous":[17],"outflow":[18],"pathway.":[19,123],"In":[20,45],"present":[22],"studies,":[23],"we":[24,48],"employed":[25],"[14C]-arachidonic":[26],"acid":[27,187],"to":[28],"explore":[29],"potentially":[30],"pathways":[32],"for":[33],"production":[35],"of":[36,69,88,102,118,120,143,162,184,192],"cultured":[39],"human":[40],"cells":[43,181],"(HTM).":[44],"these":[46],"cells,":[47],"demonstrated":[49],"that":[50,179],"prostaglandin":[51],"E2":[52],"(PGE2)":[53],"PGF2":[55,78,89],"alpha":[56,64,79,90],"are":[57,182],"major":[58],"cyclooxygenase":[59],"products,":[60],"with":[61,126,135,152],"some":[62],"6-keto-PGF1":[63],"also":[65,148],"detected.":[66],"The":[67,86],"amount":[68,87,101,142],"radiolabelled":[70,144],"PGE2":[71,103],"formed":[72,80],"was":[73,104,146,165],"substantially":[74],"higher":[75],"than":[76,196],"early":[83],"time":[84,98],"periods.":[85],"culture":[93],"media":[94],"increased":[95],"at":[96],"a":[97,107,116,189],"when":[99],"declining,":[105],"suggesting":[106],"possible":[108],"metabolic":[109],"conversion":[110],"between":[111],"prostaglandins.":[113],"HTM":[114,180],"produced":[115],"range":[117],"products":[119,164,195],"lipoxygenase":[122,163],"Products":[124],"co-eluting":[125,151],"5,":[127],"12,":[128],"15-hydroxyeicosatetraenoic":[130],"acids":[131],"(HETEs)":[132],"were":[133],"detected,":[134],"12":[136],"15-HETEs":[138],"predominating.":[139],"A":[140],"large":[141],"product":[145],"detected":[147],"peaks":[150],"leukotriene":[153],"B4":[154],"(LTB4)":[155],"an":[157],"LTB4":[158],"degradation":[159],"product.":[160],"Biosynthesis":[161],"markedly":[166],"inhibited":[167,173],"by":[168,174],"BW":[169],"755c":[170],"partially":[172],"dexamethasone.":[175],"These":[176],"data":[177],"emphasize":[178],"capable":[183],"converting":[185],"arachidonic":[186],"into":[188],"wider":[190],"variety":[191],"biologically":[193],"active":[194],"previously":[197],"recognized.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
