{"id":"https://openalex.org/W103485765","doi":null,"title":"Effect of intensive therapy on early macrovascular disease in young individuals with type 1 diabetes. A systematic review and meta-analysis.","display_name":"Effect of intensive therapy on early macrovascular disease in young individuals with type 1 diabetes. A systematic review and meta-analysis.","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W103485765","mag":"103485765","pmid":"https://pubmed.ncbi.nlm.nih.gov/10097897"},"language":"en","primary_location":{"id":"pmid:10097897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10097897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015358123","display_name":"Margaret L. Lawson","orcid":"https://orcid.org/0000-0002-2370-9552","observed_orcids":["https://orcid.org/0000-0002-2370-9552"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I2799330578","display_name":"Children's Hospital of Eastern Ontario","ror":"https://ror.org/05nsbhw27","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799330578"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M L Lawson","raw_affiliation_strings":["Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I2799330578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024577116","display_name":"Hertzel C. Gerstein","orcid":"https://orcid.org/0000-0001-8072-2836","observed_orcids":["https://orcid.org/0000-0001-8072-2836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H C Gerstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019865045","display_name":"Elaine Y. L. Tsui","orcid":"https://orcid.org/0000-0001-8200-2429","observed_orcids":["https://orcid.org/0000-0001-8200-2429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Tsui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032817714","display_name":"Bernard Zinman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Zinman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2373,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.86415393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22 Suppl 2","issue":null,"first_page":"B35","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intensive-insulin-therapy","display_name":"intensive insulin therapy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/macrovascular-complications","display_name":"macrovascular complications","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.7519999742507935},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.7950000166893005},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.6840000152587891},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.7459999918937683},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.8199999928474426},{"id":"https://openalex.org/keywords/peripheral-vascular-disease","display_name":"peripheral vascular disease","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9368464350700378},{"id":"https://openalex.org/C2778848681","wikidata":"https://www.wikidata.org/wiki/Q6725716","display_name":"Macrovascular disease","level":4,"score":0.9128141403198242},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6687822341918945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6571223139762878},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5515735149383545},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5088622570037842},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5064562559127808},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5022382736206055},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4844920337200165},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4704051613807678},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4430885314941406},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.44105789065361023},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10144913196563721},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D016239","descriptor_name":"MEDLINE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10097897","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10097897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"},{"id":"mag:103485765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10097897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089770071","https://openalex.org/W2042116693","https://openalex.org/W2042008548","https://openalex.org/W2468339705","https://openalex.org/W2239833368","https://openalex.org/W1866660160","https://openalex.org/W2395195143","https://openalex.org/W4384820425","https://openalex.org/W2183573783","https://openalex.org/W1595367857"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1],"conducted":[2],"a":[3],"systematic":[4],"review":[5],"of":[6,11,45,113,123,144,174,192],"randomized":[7],"controlled":[8],"trials":[9],"(RCTs)":[10],"intensive":[12],"insulin":[13],"therapy":[14,54],"(IIT)":[15],"in":[16,56,178,211],"type":[17,57,115,182],"1":[18,58,183],"diabetes":[19,184],"to":[20,42,52],"determine":[21],"the":[22,121,142,172,190],"effect":[23,140,188],"on":[24,85,141,158,189,196],"macrovascular":[25,80,86,124,147,159,176,197,206],"complications.":[26,81],"RESEARCH":[27],"DESIGN":[28],"AND":[29],"METHODS:":[30],"MEDLINE":[31],"(1966-1996),":[32],"Citation":[33],"Index,":[34],"reference":[35],"lists,":[36],"and":[37,66,88],"personal":[38],"files":[39],"were":[40,71,77,83],"used":[41],"identify":[43],"RCTs":[44],">":[46],"2":[47],"years'":[48],"duration":[49],"comparing":[50],"IIT":[51,119,170,203],"conventional":[53],"(CT)":[55],"diabetes.":[59],"Two":[60],"independent":[61],"reviewers":[62],"applied":[63],"selection":[64],"criteria":[65],"identified":[67],"11":[68],"studies;":[69],"5":[70],"subsequently":[72],"excluded":[73],"because":[74],"no":[75,138,187],"data":[76,200],"available":[78],"for":[79],"Data":[82],"extracted":[84],"disease":[87,93,148,177,207],"cardiovascular":[89],"risk":[90],"factors.":[91],"Macrovascular":[92],"was":[94,116],"defined":[95],"as":[96],"angina,":[97],"myocardial":[98],"infarction,":[99],"angioplasty,":[100],"coronary":[101],"artery":[102],"bypass":[103],"graft,":[104],"stroke,":[105],"claudication,":[106],"or":[107,157,195,208],"peripheral":[108],"bypass.":[109],"The":[110],"first":[111],"event":[112],"each":[114],"counted.":[117],"RESULTS:":[118],"decreased":[120],"number":[122,143,191],"events":[125],"(odds":[126],"ratio":[127],"[OR]":[128],"0.55,":[129],"[95%":[130,151,163],"CI":[131,152,164],"0.35-0.88],":[132],"P":[133,154,166],"=":[134,155,167],"0.015)":[135],"but":[136,185],"had":[137],"significant":[139],"patients":[145,193],"developing":[146],"(OR":[149,161],"0.72,":[150],"0.44-1.17],":[153],"0.22)":[156],"mortality":[160],"0.91,":[162],"0.31-2.65],":[165],"0.93).":[168],"CONCLUSIONS:":[169],"decreases":[171],"extent":[173],"early":[175],"young":[179],"individuals":[180],"with":[181],"has":[186],"affected":[194],"mortality.":[198],"These":[199],"suggest":[201],"that":[202],"may":[204],"stabilize":[205],"prevent":[209],"progression":[210],"those":[212],"at":[213],"risk.":[214]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
