{"id":"https://openalex.org/W1034551901","doi":null,"title":"Impact of treatment with methimazole on the Bcl-2 expression in CD8+ peripheral blood lymphocytes in children with Graves' disease.","display_name":"Impact of treatment with methimazole on the Bcl-2 expression in CD8+ peripheral blood lymphocytes in children with Graves' disease.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1034551901","mag":"1034551901","pmid":"https://pubmed.ncbi.nlm.nih.gov/24364474"},"language":"en","primary_location":{"id":"pmid:24364474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24364474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of agricultural and environmental medicine : AAEM","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052625165","display_name":"Maria Klatka","orcid":"https://orcid.org/0000-0002-2743-8139","observed_orcids":["https://orcid.org/0000-0002-2743-8139"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Maria Klatka","raw_affiliation_strings":["Department of Pediatric Endocrinology and Diabetology,Medical University, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Endocrinology and Diabetology,Medical University, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061121227","display_name":"Ewelina Grywalska","orcid":"https://orcid.org/0000-0002-0451-4741","observed_orcids":["https://orcid.org/0000-0002-0451-4741"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewelina Grywalska","raw_affiliation_strings":["Department of Clinical Immunology and Immunotherapy, Medical University, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology and Immunotherapy, Medical University, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082666040","display_name":"Agnieszka Polak","orcid":"https://orcid.org/0000-0003-1694-4738","observed_orcids":["https://orcid.org/0000-0003-1694-4738","https://orcid.org/0000-0001-8954-8774","https://orcid.org/0000-0001-7306-1427"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Agnieszka Polak","raw_affiliation_strings":["Department of Clinical Immunology and Immunotherapy, Medical University, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology and Immunotherapy, Medical University, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085299270","display_name":"Jacek Roli\u0144ski","orcid":"https://orcid.org/0000-0003-4841-6120","observed_orcids":["https://orcid.org/0000-0003-4841-6120","https://orcid.org/0000-0001-5596-2651"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jacek Roli\u0144ski","raw_affiliation_strings":["Department of Clinical Immunology and Immunotherapy, Medical University, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology and Immunotherapy, Medical University, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I121032520"],"apc_list":null,"apc_paid":null,"fwci":0.2037,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57159886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"20","issue":"4","first_page":"884","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/methimazole","display_name":"methimazole","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pediatric-thyroid-disease","display_name":"pediatric thyroid disease","score":0.621999979019165},{"id":"https://openalex.org/keywords/antithyroid-drug-therapy","display_name":"antithyroid drug therapy","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7229663133621216},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6702222228050232},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.6579036116600037},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5538880228996277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.508864164352417},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5025804042816162},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4665757119655609},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.45261839032173157},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44150179624557495},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41979244351387024},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39667993783950806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14482465386390686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008713","descriptor_name":"Methimazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:24364474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24364474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of agricultural and environmental medicine : AAEM","raw_type":"Journal Article"},{"id":"mag:1034551901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24364474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1968299684","https://openalex.org/W1971783269","https://openalex.org/W1980100638","https://openalex.org/W1982432478","https://openalex.org/W1984273763","https://openalex.org/W1991666450","https://openalex.org/W2028530739","https://openalex.org/W2032279316","https://openalex.org/W2035478739","https://openalex.org/W2049885431","https://openalex.org/W2080375558","https://openalex.org/W2081421763","https://openalex.org/W2084559406","https://openalex.org/W2087194312","https://openalex.org/W2087877138","https://openalex.org/W2112027904","https://openalex.org/W2118978221","https://openalex.org/W2127432084","https://openalex.org/W2132552212","https://openalex.org/W2139932592","https://openalex.org/W2147374444","https://openalex.org/W2148965427","https://openalex.org/W2169010806"],"related_works":["https://openalex.org/W1971783269","https://openalex.org/W4282598892","https://openalex.org/W2386717028","https://openalex.org/W1969695216","https://openalex.org/W1991666450","https://openalex.org/W2055577777","https://openalex.org/W2126452051","https://openalex.org/W2051682802","https://openalex.org/W2168762628","https://openalex.org/W4985366"],"abstract_inverted_index":{"INTRODUCTION":[0],"AND":[1,87],"OBJECTIVES:":[2],"The":[3,18,40,49,115,166,180,195],"protein":[4,60,148],"product":[5],"of":[6,14,34,44,51,56,58,146,154,168,197,202,211,231,240,250],"the":[7,32,113,144,200,209,212,216,226,229,234,238,248],"proto-oncogene":[8],"Bcl-2":[9,59,123,147,169,183,213,232],"is":[10,46],"a":[11],"physiological":[12],"inhibitor":[13],"programmed":[15],"cell":[16],"death.":[17],"results":[19],"obtained":[20],"in":[21,31,38,61,66,81,149,162,182,199,219,228,247],"our":[22],"previous":[23],"researches":[24],"suggest":[25,224],"that":[26,143,225],"apoptosis":[27],"may":[28],"be":[29],"involved":[30],"regulation":[33],"an":[35],"immune":[36],"response":[37],"hyperthyroidism.":[39],"most":[41],"common":[42],"cause":[43],"hyperthyroidism":[45,203],"Graves'":[47,71],"disease.":[48],"aim":[50],"this":[52],"study":[53,141],"was":[54,124,158,192],"evaluation":[55],"expression":[57,145,167,184,214,230],"peripheral":[62,220],"blood":[63],"T":[64,152],"lymphocytes":[65,153,218],"hyperthyroid":[67],"children":[68,90],"due":[69,95,204],"to":[70,96,177,205,208],"disease":[72],"(GD)":[73],"before":[74,98],"and":[75,99,106,122,131,137,189,243],"after":[76,100,129,170,187],"therapy":[77,173],"with":[78,83,91,104,117,133,156,174],"methimazole":[79],"(MMI),":[80],"comparison":[82],"healthy":[84,108,163],"controls.":[85],"MATERIAL":[86],"METHODS:":[88],"Thirty-two":[89],"newly":[92],"diagnosed":[93],"hyperthyreosis":[94,157],"GD":[97,206],"4-6":[101,171],"weeks":[102],"treatment":[103,188,201],"MMI,":[105],"20":[107],"controls":[109,164],"were":[110],"included":[111],"into":[112],"study.":[114],"staining":[116],"monoclonal":[118],"antibodies":[119],"against":[120],"CD8":[121],"performed":[125],"within":[126],"2":[127],"hours":[128],"collection,":[130],"followed":[132],"flow":[134],"cytometry":[135],"acquisition":[136],"analysis.":[138],"RESULTS:":[139],"Our":[140,222],"revealed":[142],"circulating":[150],"CD8+":[151,217,235],"patients":[155,186],"significantly":[159],"lower":[160],"than":[161],"(p<0.03).":[165],"week":[172],"MMI":[175,198],"returned":[176],"normal":[178],"level.":[179],"difference":[181],"between":[185],"control":[190],"group":[191],"insignificant.":[193],"CONCLUSIONS:":[194],"use":[196],"leads":[207],"normalization":[210],"on":[215,233],"blood.":[221],"findings":[223],"changes":[227],"cells":[236,242],"indicate":[237],"involvement":[239],"these":[241],"Bcl-2-regulated":[244],"apoptotic":[245],"pathway":[246],"pathogenesis":[249],"GD.":[251]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
