{"id":"https://openalex.org/W10339573","doi":null,"title":"elk-1 proteins interact with MAP kinases.","display_name":"elk-1 proteins interact with MAP kinases.","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W10339573","mag":"10339573","pmid":"https://pubmed.ncbi.nlm.nih.gov/8208531"},"language":"en","primary_location":{"id":"pmid:8208531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8208531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113899427","display_name":"V. N. Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V N Rao","raw_affiliation_strings":["Department of Microbiology and Immunology, Jefferson Cancer Institute, Philadelphia, Pennsylvania 19107-5541"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Jefferson Cancer Institute, Philadelphia, Pennsylvania 19107-5541","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113756945","display_name":"E Shyam P Reddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E S Reddy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8047,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.85083571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"9","issue":"7","first_page":"1855","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elk-1","display_name":"Elk-1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mapk-activation","display_name":"MAPK activation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ets-transcription-factors","display_name":"ETS transcription factors","score":0.7149999737739563},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7329999804496765},{"id":"https://openalex.org/keywords/autophosphorylation","display_name":"autophosphorylation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/c-fos-transcription","display_name":"c-fos transcription","score":0.6549999713897705},{"id":"https://openalex.org/keywords/egf-stimulation","display_name":"EGF stimulation","score":0.5630000233650208},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C163035849","wikidata":"https://www.wikidata.org/wiki/Q15326910","display_name":"MAPK14","level":5,"score":0.8052837252616882},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7182403802871704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7122816443443298},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.6882114410400391},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.671749472618103},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.5694732069969177},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5387886762619019},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5316603183746338},{"id":"https://openalex.org/C99405784","wikidata":"https://www.wikidata.org/wiki/Q410434","display_name":"c-Raf","level":5,"score":0.5146909356117249},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.4771689474582672},{"id":"https://openalex.org/C138227536","wikidata":"https://www.wikidata.org/wiki/Q18030789","display_name":"MAPK7","level":5,"score":0.468955934047699},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4272882044315338},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.4216083288192749},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.42100194096565247},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.4053586423397064},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.3069807291030884},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.29825878143310547},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.25913184881210327},{"id":"https://openalex.org/C155985219","wikidata":"https://www.wikidata.org/wiki/Q409325","display_name":"Extracellular signal-regulated kinases","level":4,"score":0.13718026876449585}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015682","descriptor_name":"Retroviridae Proteins, Oncogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050807","descriptor_name":"ets-Domain Protein Elk-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8208531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8208531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:10339573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8208531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3730128127","display_name":"ONCOGENES IN CANCER ETIOLOGY AND PROGRESSION","funder_award_id":"P01CA050507","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1502767888","https://openalex.org/W1630201176","https://openalex.org/W1780928079","https://openalex.org/W1801106228","https://openalex.org/W2118929543","https://openalex.org/W2149717212","https://openalex.org/W2228439981","https://openalex.org/W2408972802"],"related_works":["https://openalex.org/W1546152863","https://openalex.org/W912507531","https://openalex.org/W2122510832","https://openalex.org/W2110911902","https://openalex.org/W1993433059","https://openalex.org/W2046314213","https://openalex.org/W2028333426","https://openalex.org/W2118457425","https://openalex.org/W2002282120","https://openalex.org/W1997075903"],"abstract_inverted_index":{"Mitogen":[0],"activated":[1,21],"protein":[2,9,16,174],"kinases":[3,10,18,126,142,251],"(MAP)":[4],"or":[5],"extracellular":[6,28],"signal":[7],"regulated":[8],"(ERK)":[11],"are":[12,20,51],"a":[13,148,193],"family":[14],"of":[15,49,58,80,93,95,100,112,121,140,165,172,183,196,236,249],"serine/threonine":[17,257],"that":[19,221],"very":[22],"rapidly":[23],"in":[24,86],"response":[25],"to":[26,68,75,89,108,136,190,211],"many":[27],"stimuli.":[29],"elk-1,":[30,40,47],"an":[31,78,87,197,237],"ets":[32],"related":[33],"gene":[34],"codes":[35],"for":[36,53,178,246],"two":[37],"transcriptional":[38,61],"factors":[39],"which":[41,50,65,187,205],"regulates":[42],"c-fos":[43],"transcription":[44],"and":[45,103,151,155,167,208,259],"delta":[46],"both":[48,69],"substrates":[52],"MAP":[54,81,96,116,125,141,203,229,242,250],"kinases.":[55,82,117],"A":[56],"part":[57],"the":[59,70,91,110,138,163,234,247],"C-terminal":[60],"activation":[62,94,156,159,248,260],"domain":[63],"(ETA-2)":[64],"is":[66],"common":[67],"proteins":[71,105,114,123,134,223],"was":[72,160,175,209],"previously":[73],"shown":[74],"function":[76],"as":[77],"activator":[79],"In":[83,169],"this":[84],"report,":[85],"attempt":[88],"investigate":[90],"mechanism":[92],"kinases,":[97],"purified":[98],"preparations":[99],"recombinant":[101],"elk-1":[102,113,122,133,173,184,198,222,262],"P44mpk/ERK-1/ERK-2":[104],"were":[106,127,188],"used":[107],"show":[109],"association":[111],"with":[115,124,145,214,252],"The":[118,158],"specific":[119,199],"interactions":[120],"confirmed":[128],"by":[129,143,261],"co-immunoprecipitation":[130],"studies.":[131],"Thus":[132],"appear":[135],"regulate":[137],"activity":[139,182],"interacting":[144],"them":[146],"ensuring":[147],"conformational":[149],"change":[150],"stimulating":[152],"their":[153],"autophosphorylation":[154,258],"property.":[157],"dependent":[161],"on":[162],"presence":[164,235],"ATP":[166],"Mg2+.":[168],"vitro":[170],"phosphorylation":[171,254],"not":[176],"regulatory":[177],"autonomous":[179],"DNA":[180],"binding":[181],"protein.":[185],"Cells":[186],"exposed":[189],"EGF":[191],"showed":[192],"rapid":[194],"stimulation":[195],"kinase":[200,204,243],"activity,":[201],"probably":[202],"phosphorylated":[206,228],"MBP":[207],"found":[210],"be":[212],"associated":[213],"immobilized":[215],"GST-elk-1.":[216],"Furthermore,":[217],"dephosphorylation":[218],"studies":[219],"indicate":[220],"can":[224],"activate":[225],"only":[226],"tyrosine":[227,253],"kinase.":[230],"These":[231],"results":[232],"demonstrate":[233],"alternative":[238],"pathway/mechanism":[239],"(other":[240],"than":[241],"kinase,":[244],"MAPKK/Mek)":[245],"occurring":[255],"before":[256],"proteins.":[263]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}