{"id":"https://openalex.org/W1033332212","doi":null,"title":"Computational simulation of chronic persistent virus infection: factors determining differences in clinical outcome of HHV-6, HIV-1 and HTLV-1 infections including aplastic, hyperplastic and neoplastic responses.","display_name":"Computational simulation of chronic persistent virus infection: factors determining differences in clinical outcome of HHV-6, HIV-1 and HTLV-1 infections including aplastic, hyperplastic and neoplastic responses.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1033332212","mag":"1033332212","pmid":"https://pubmed.ncbi.nlm.nih.gov/15015596"},"language":"en","primary_location":{"id":"pmid:15015596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15015596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112199611","display_name":"G. R. F. Krueger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337852284","display_name":"Texas Medical Center","ror":"https://ror.org/00dqsbj20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1337852284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G R F Krueger","raw_affiliation_strings":["Department of Internal Medicine, University of Texas-Houston Medical School, Houston, Texas 77030, USA. Gerhard.Krueger@uth.tmc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas-Houston Medical School, Houston, Texas 77030, USA. Gerhard.Krueger@uth.tmc.edu","institution_ids":["https://openalex.org/I1337852284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111884160","display_name":"Michael E. Brandt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Brandt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034216027","display_name":"G Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038526875","display_name":"Louis Maximilian Buja","orcid":"https://orcid.org/0000-0001-8386-7029","observed_orcids":["https://orcid.org/0000-0001-8386-7029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L M Buja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1068,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.3284413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":"187","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.15649999678134918,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/human-herpesvirus-6","display_name":"human herpesvirus 6","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.9449999928474426},{"id":"https://openalex.org/keywords/aplasia","display_name":"aplasia","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hyperplasia","display_name":"hyperplasia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.654466986656189},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.561432957649231},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5532433986663818},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4291277527809143},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.4254938066005707},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41909435391426086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4099772572517395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3641566038131714},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19714298844337463}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015490","descriptor_name":"HTLV-I Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015490","descriptor_name":"HTLV-I Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015654","descriptor_name":"Herpesvirus 6, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019349","descriptor_name":"Roseolovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019349","descriptor_name":"Roseolovirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15015596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15015596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},{"id":"mag:1033332212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15015596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W17446959","https://openalex.org/W65130119","https://openalex.org/W168058771","https://openalex.org/W1629340914","https://openalex.org/W1969606315","https://openalex.org/W1970039422","https://openalex.org/W1992716617","https://openalex.org/W2002627787","https://openalex.org/W2012524901","https://openalex.org/W2040787119","https://openalex.org/W2063485002","https://openalex.org/W2067371565","https://openalex.org/W2074897557","https://openalex.org/W2116589659","https://openalex.org/W2127652935","https://openalex.org/W2129694350","https://openalex.org/W2137267461","https://openalex.org/W2138896835","https://openalex.org/W2143271547","https://openalex.org/W2150202027","https://openalex.org/W2154701060","https://openalex.org/W2256062038","https://openalex.org/W2401788324","https://openalex.org/W2406858656","https://openalex.org/W2413469843","https://openalex.org/W2414653540","https://openalex.org/W2418104929","https://openalex.org/W3185600017"],"related_works":["https://openalex.org/W1990507981","https://openalex.org/W1526372301","https://openalex.org/W2414653540","https://openalex.org/W2408932790","https://openalex.org/W27352116","https://openalex.org/W2183885366","https://openalex.org/W86096886","https://openalex.org/W234137079","https://openalex.org/W2065351773","https://openalex.org/W2064059889"],"abstract_inverted_index":{"A":[0],"computational":[1],"model":[2,17],"was":[3,18,47],"recently":[4],"designed":[5],"to":[6],"simulate":[7],"cellular":[8],"changes":[9,23,77],"in":[10,24,111],"the":[11,29,80,84],"T":[12,32,62],"cell":[13,22,63,69],"immune":[14],"system.":[15],"The":[16],"validated":[19],"by":[20,89],"simulating":[21],"viral":[25],"infections":[26,51,86],"which":[27],"target":[28],"same":[30],"CD4+":[31],"cell,":[33],"yet":[34],"cause":[35],"either":[36],"hyperplastic,":[37],"aplastic":[38],"or":[39,60,104],"neoplastic":[40],"responses.":[41],"Respective":[42],"case":[43],"material":[44],"for":[45,71],"comparison":[46],"available":[48],"from":[49],"human":[50,53,56,61,74],"with":[52,68,101],"herpesvirus-6":[54],"(HHV-6),":[55],"immunodeficiency":[57],"virus":[58,65],"(HIV-1)":[59],"leukemia":[64],"(HTLV-1).":[66],"Starting":[67],"values":[70],"a":[72,98],"healthy":[73],"individual,":[75],"factorial":[76,95],"that":[78],"influence":[79],"individual":[81],"course":[82,100],"of":[83],"various":[85],"were":[87],"determined":[88],"an":[90],"algorithm":[91],"search":[92],"procedure.":[93],"Such":[94],"differences":[96],"determining":[97],"clinical":[99],"aplasia,":[102],"hyperplasia":[103],"neoplasia":[105],"are":[106],"outlined":[107],"and":[108],"further":[109],"discussed":[110],"this":[112],"paper.":[113]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}