{"id":"https://openalex.org/W103305319","doi":null,"title":"Forkhead box protein 3 mRNA expression in the peripheral blood of kidney-transplant recipients with acute rejection.","display_name":"Forkhead box protein 3 mRNA expression in the peripheral blood of kidney-transplant recipients with acute rejection.","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W103305319","mag":"103305319","pmid":"https://pubmed.ncbi.nlm.nih.gov/21740831"},"language":"en","primary_location":{"id":"pmid:21740831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21740831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100652493","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0003-2642-3338","observed_orcids":["https://orcid.org/0000-0003-2642-3338"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. zico73@medmail.com.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. zico73@medmail.com.cn","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao-Bei Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Bei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040079151","display_name":"Xiaoyong Yang","orcid":"https://orcid.org/0000-0001-7263-3913","observed_orcids":["https://orcid.org/0000-0001-7263-3913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Yong Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100376244","display_name":"Xiaodong Zhang","orcid":"https://orcid.org/0000-0003-4677-1620","observed_orcids":["https://orcid.org/0000-0003-4677-1620"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Dong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9139,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.72689512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"124","issue":"12","first_page":"1775","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9120000004768372},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.8849999904632568},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.6930000185966492},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8190000057220459},{"id":"https://openalex.org/keywords/living-related-donors","display_name":"living related donors","score":0.5680000185966492},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.8732602596282959},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.708234429359436},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6482341289520264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6228780746459961},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.5702118873596191},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5202621221542358},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.435019314289093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3994540274143219},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.38314419984817505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28323879837989807},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1666257083415985},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11484143137931824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:21740831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21740831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:103305319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21740831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3146765014","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85656X/201112/38613791.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541197","display_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4398234399","https://openalex.org/W2350831425","https://openalex.org/W2079423925","https://openalex.org/W1575508942","https://openalex.org/W2156504601","https://openalex.org/W2078439364","https://openalex.org/W2059467273","https://openalex.org/W4213206698","https://openalex.org/W2056813251","https://openalex.org/W3215111624"],"abstract_inverted_index":{"BACKGROUND:":[0],"Regulatory":[1],"T":[2,50],"cells":[3],"(Tregs)":[4],"are":[5],"immunologically":[6],"and":[7,63,101,180,234],"clinically":[8],"interesting":[9],"not":[10],"least":[11],"because":[12,41],"of":[13,24,39,42,48,86,257],"the":[14,25,46,57,99,126,164,204,254],"important":[15],"role":[16,44],"they":[17],"play":[18],"in":[19,34,45,67,79,112,138,163,220,253,267,279],"allograft":[20],"rejection.":[21,271,293],"Likewise,":[22],"expression":[23,62,77,136,175,212],"transcription":[26],"factor":[27],"forkhead":[28],"box":[29],"protein":[30],"3":[31],"(FOXP3),":[32],"detected":[33],"transplant":[35],"biopsies,":[36],"is":[37],"also":[38],"interest":[40],"its":[43],"development":[47],"regulatory":[49],"cells.":[51],"In":[52,71,105],"this":[53,72],"study,":[54,74,115],"we":[55],"investigated":[56],"relationship":[58],"between":[59,144],"FoxP3":[60,75,134,153,173,206,246,262,276],"mRNA":[61,76,135,154,158,174,207,211,247,263,277],"acute":[64,122,223,270,292],"organ":[65,123],"rejection":[66,224],"kidney-transplant":[68,109],"recipients.":[69,259],"METHODS:":[70],"prospective":[73],"levels":[78,137,155,159,176,208,213,248,264,278],"peripheral":[80,139,255,280],"blood":[81,140,256,281],"samples":[82,141,282],"from":[83],"10":[84,165],"recipients":[85,110,166,221,268],"living":[87],"relative-donor":[88],"kidney":[89,244],"transplants":[90],"were":[91,142,167,184,217,249,265],"measured":[92,177],"before":[93,188],"transplantation":[94,151,189],"as":[95,97,120,286],"well":[96],"at":[98,178],"14th":[100,179],"90th":[102,181],"days":[103,182],"post-transplantation.":[104],"addition,":[106],"46":[107],"first-time":[108],"participated":[111],"a":[113,287],"cross-sectional":[114],"with":[116,226,228],"28":[117],"patients":[118,129],"classified":[119],"having":[121],"rejection;":[124],"whilst":[125],"remaining":[127],"18":[128],"had":[130],"functionally":[131],"stable":[132,229],"allografts.":[133],"compared":[143,225],"these":[145],"two":[146],"different":[147],"groups.":[148],"RESULTS:":[149],"Before":[150],"mean":[152,172,205],"vs.":[156,209],"GADPH":[157,210],"(lg(FoxP3":[160,214],"mRNA/GADPH":[161,215],"mRNA))":[162,216],"1.11":[168],"\u00b1":[169,191,197,232,236],"0.67.":[170],"The":[171],"post-transplantation":[183],"significantly":[185,218],"higher":[186,219,261],"than":[187],"(1.69":[190],"0.38,":[192],"P":[193,199,239],"=":[194,200,240],"0.03;":[195],"1.44":[196],"0.21,":[198],"0.04,":[201],"respectively).":[202],"Additionally,":[203],"suffering":[222,269],"those":[227],"allografts":[230],"(1.77":[231],"0.61":[233],"1.43":[235],"0.27,":[237],"respectively,":[238],"0.03).":[241],"CONCLUSIONS:":[242],"After":[243],"transplantation,":[245],"found":[250],"to":[251],"increase":[252],"all":[258],"Considerably":[260],"observed":[266],"These":[272],"results":[273],"suggest":[274],"that":[275],"can":[283],"be":[284],"used":[285],"diagnostic":[288],"tool":[289],"for":[290],"identifying":[291]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}