{"id":"https://openalex.org/W103288219","doi":"https://doi.org/10.1007/978-94-017-3345-8_29","title":"Ex vivo hepatocyte-directed gene therapy","display_name":"Ex vivo hepatocyte-directed gene therapy","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W103288219","doi":"https://doi.org/10.1007/978-94-017-3345-8_29","mag":"103288219"},"language":"en","primary_location":{"id":"doi:10.1007/978-94-017-3345-8_29","doi":"https://doi.org/10.1007/978-94-017-3345-8_29","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-94-017-3345-8_29","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Hepatocyte Review","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W641642482","display_name":"The Hepatocyte Review"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108437486","display_name":"Steven E. Raper","orcid":"https://orcid.org/0000-0001-9191-4681","observed_orcids":["https://orcid.org/0000-0001-9191-4681"]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Raper","raw_affiliation_strings":["Institute for Human Gene Therapy, University of Pennsylvania Medical Center, 607BRBII/III 421 Curie Blvd, Philadelphia, PA, 19104-6160, USA","Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Human Gene Therapy, University of Pennsylvania Medical Center, 607BRBII/III 421 Curie Blvd, Philadelphia, PA, 19104-6160, USA","institution_ids":["https://openalex.org/I4210143392","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078049281","display_name":"Albert D. Moscioni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. David Moscioni","raw_affiliation_strings":["Institute for Human Gene Therapy, University of Pennsylvania Medical Center, 607BRBII/III 421 Curie Blvd, Philadelphia, PA, 19104-6160, USA","Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Human Gene Therapy, University of Pennsylvania Medical Center, 607BRBII/III 421 Curie Blvd, Philadelphia, PA, 19104-6160, USA","institution_ids":["https://openalex.org/I4210143392","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"503","last_page":"520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ex-vivo-gene-therapy","display_name":"ex vivo gene therapy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/liver-directed-gene-delivery","display_name":"liver-directed gene delivery","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hepatocyte-transduction","display_name":"hepatocyte transduction","score":0.640999972820282},{"id":"https://openalex.org/keywords/transgene-integration","display_name":"transgene integration","score":0.7820000052452087},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/somatic-gene-therapy","display_name":"somatic gene therapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7745946645736694},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7530836462974548},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5793353319168091},{"id":"https://openalex.org/C2781161190","wikidata":"https://www.wikidata.org/wiki/Q1055374","display_name":"Adenosine deaminase deficiency","level":4,"score":0.5636444091796875},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5515782237052917},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5425875186920166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5359606742858887},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.5035924315452576},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.45728060603141785},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.44666677713394165},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4290739893913269},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4196498394012451},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.41631802916526794},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.414113312959671},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.39996635913848877},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33829379081726074},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3023217022418976},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2734465003013611},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1783873736858368},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.13417011499404907},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-94-017-3345-8_29","doi":"https://doi.org/10.1007/978-94-017-3345-8_29","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-94-017-3345-8_29","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Hepatocyte Review","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W186822711","https://openalex.org/W220966803","https://openalex.org/W648601620","https://openalex.org/W1255813291","https://openalex.org/W1506918742","https://openalex.org/W1512554485","https://openalex.org/W1525063665","https://openalex.org/W1593177203","https://openalex.org/W1704094093","https://openalex.org/W1856725759","https://openalex.org/W1891666617","https://openalex.org/W1901315342","https://openalex.org/W1971032167","https://openalex.org/W1972832005","https://openalex.org/W1983728851","https://openalex.org/W1985192507","https://openalex.org/W1987368916","https://openalex.org/W1991037396","https://openalex.org/W1993326517","https://openalex.org/W1993367141","https://openalex.org/W1995612506","https://openalex.org/W1997482819","https://openalex.org/W1997778628","https://openalex.org/W2000101394","https://openalex.org/W2002333878","https://openalex.org/W2004818604","https://openalex.org/W2009303445","https://openalex.org/W2009761723","https://openalex.org/W2011767474","https://openalex.org/W2013359336","https://openalex.org/W2014397874","https://openalex.org/W2023184383","https://openalex.org/W2023962152","https://openalex.org/W2025517694","https://openalex.org/W2028768981","https://openalex.org/W2032564106","https://openalex.org/W2036714116","https://openalex.org/W2040846175","https://openalex.org/W2045367705","https://openalex.org/W2046520047","https://openalex.org/W2047458913","https://openalex.org/W2048052186","https://openalex.org/W2051742401","https://openalex.org/W2062723580","https://openalex.org/W2063338839","https://openalex.org/W2067189573","https://openalex.org/W2067379696","https://openalex.org/W2068764558","https://openalex.org/W2070749270","https://openalex.org/W2076003033","https://openalex.org/W2086584640","https://openalex.org/W2089582480","https://openalex.org/W2089970931","https://openalex.org/W2091757239","https://openalex.org/W2092716180","https://openalex.org/W2097154687","https://openalex.org/W2098290992","https://openalex.org/W2105007068","https://openalex.org/W2118944608","https://openalex.org/W2142648055","https://openalex.org/W2166797660","https://openalex.org/W2170278936","https://openalex.org/W2177849941","https://openalex.org/W2334694763","https://openalex.org/W2337414415","https://openalex.org/W2395663099","https://openalex.org/W2415633212","https://openalex.org/W2416671861","https://openalex.org/W2417933998","https://openalex.org/W2418194054","https://openalex.org/W2443845705","https://openalex.org/W3145894777"],"related_works":["https://openalex.org/W2435339564","https://openalex.org/W2270941836","https://openalex.org/W1911841216","https://openalex.org/W2915524934","https://openalex.org/W2416671861","https://openalex.org/W2112343375","https://openalex.org/W1980229872","https://openalex.org/W2067985097","https://openalex.org/W2443845705","https://openalex.org/W1975658477"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}