{"id":"https://openalex.org/W1032394645","doi":null,"title":"PRECLINICAL STUDIES ON ATM KINASE INHIBITORS AS ANTI-CANCER AGENTS","display_name":"PRECLINICAL STUDIES ON ATM KINASE INHIBITORS AS ANTI-CANCER AGENTS","publication_year":2011,"publication_date":"2011-08-04","ids":{"openalex":"https://openalex.org/W1032394645","mag":"1032394645"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:8872","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/8872/1/ETD_Choi_2011.pdf","pdf_url":"http://d-scholarship.pitt.edu/8872/1/ETD_Choi_2011.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/8872/1/ETD_Choi_2011.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103224908","display_name":"Serah Choi","orcid":"https://orcid.org/0000-0003-4968-2981","observed_orcids":["https://orcid.org/0000-0003-4968-2981"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Serah Choi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4968-2981","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103224908"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05025615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ataxia-telangiectasia-mutated","display_name":"ATM kinase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ku55933","display_name":"KU55933","score":0.9639999866485596},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8820000290870667},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.8600000143051147},{"id":"https://openalex.org/keywords/53bp1","display_name":"53BP1","score":0.8840000033378601},{"id":"https://openalex.org/keywords/spatial-proteomics","display_name":"spatial proteomics","score":0.8080000281333923},{"id":"https://openalex.org/keywords/sister-chromatid-exchange","display_name":"sister chromatid exchange","score":0.8709999918937683},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9509999752044678},{"id":"https://openalex.org/keywords/h460-cells","display_name":"H460 cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6434152722358704},{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.5969545841217041},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.5715211629867554},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5608547329902649},{"id":"https://openalex.org/C68748289","wikidata":"https://www.wikidata.org/wiki/Q18030783","display_name":"DNA-PKcs","level":4,"score":0.5355750322341919},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.49856019020080566},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.482567697763443},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.47461310029029846},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4572673738002777},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.43922510743141174},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.431243360042572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4308062195777893},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.41573023796081543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40578675270080566},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.38760906457901},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26756715774536133},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.23036319017410278},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22714370489120483},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.15881171822547913}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:8872","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/8872/1/ETD_Choi_2011.pdf","pdf_url":"http://d-scholarship.pitt.edu/8872/1/ETD_Choi_2011.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:1032394645","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/8872/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:8872","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/8872/1/ETD_Choi_2011.pdf","pdf_url":"http://d-scholarship.pitt.edu/8872/1/ETD_Choi_2011.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1032394645.pdf","grobid_xml":"https://content.openalex.org/works/W1032394645.grobid-xml"},"referenced_works_count":159,"referenced_works":["https://openalex.org/W143544902","https://openalex.org/W176940746","https://openalex.org/W1487477578","https://openalex.org/W1529396499","https://openalex.org/W1541806623","https://openalex.org/W1603627149","https://openalex.org/W1650797637","https://openalex.org/W1964616851","https://openalex.org/W1964951140","https://openalex.org/W1967195525","https://openalex.org/W1967630574","https://openalex.org/W1968960110","https://openalex.org/W1970227011","https://openalex.org/W1972910961","https://openalex.org/W1973063910","https://openalex.org/W1973268287","https://openalex.org/W1977088495","https://openalex.org/W1978331091","https://openalex.org/W1978754000","https://openalex.org/W1979385111","https://openalex.org/W1979568780","https://openalex.org/W1979710795","https://openalex.org/W1982061874","https://openalex.org/W1982308446","https://openalex.org/W1985623956","https://openalex.org/W1986179131","https://openalex.org/W1986947222","https://openalex.org/W1987146639","https://openalex.org/W1987577420","https://openalex.org/W1988876917","https://openalex.org/W1991494214","https://openalex.org/W1992630665","https://openalex.org/W1992783373","https://openalex.org/W1996910195","https://openalex.org/W2000285763","https://openalex.org/W2005939114","https://openalex.org/W2006379287","https://openalex.org/W2009007206","https://openalex.org/W2011159055","https://openalex.org/W2014033593","https://openalex.org/W2017297714","https://openalex.org/W2017934591","https://openalex.org/W2018614123","https://openalex.org/W2019239618","https://openalex.org/W2019405732","https://openalex.org/W2022529631","https://openalex.org/W2022811243","https://openalex.org/W2023620387","https://openalex.org/W2025246434","https://openalex.org/W2029159424","https://openalex.org/W2033172828","https://openalex.org/W2033371646","https://openalex.org/W2033651349","https://openalex.org/W2035917674","https://openalex.org/W2036490858","https://openalex.org/W2036911210","https://openalex.org/W2036933656","https://openalex.org/W2038451572","https://openalex.org/W2038762568","https://openalex.org/W2040881136","https://openalex.org/W2042480414","https://openalex.org/W2042499074","https://openalex.org/W2043972688","https://openalex.org/W2044958378","https://openalex.org/W2046083330","https://openalex.org/W2047447041","https://openalex.org/W2049262839","https://openalex.org/W2049921243","https://openalex.org/W2050293462","https://openalex.org/W2050608484","https://openalex.org/W2054689508","https://openalex.org/W2055148721","https://openalex.org/W2056461221","https://openalex.org/W2058601529","https://openalex.org/W2061060103","https://openalex.org/W2061255397","https://openalex.org/W2062284662","https://openalex.org/W2063117678","https://openalex.org/W2064377499","https://openalex.org/W2069651213","https://openalex.org/W2070632817","https://openalex.org/W2070794214","https://openalex.org/W2071411482","https://openalex.org/W2072744580","https://openalex.org/W2074177924","https://openalex.org/W2075036506","https://openalex.org/W2077436902","https://openalex.org/W2078242581","https://openalex.org/W2078328982","https://openalex.org/W2079185082","https://openalex.org/W2084745121","https://openalex.org/W2084969545","https://openalex.org/W2087041160","https://openalex.org/W2087505934","https://openalex.org/W2089218510","https://openalex.org/W2089574530","https://openalex.org/W2090242035","https://openalex.org/W2090307950","https://openalex.org/W2090438862","https://openalex.org/W2090564839","https://openalex.org/W2091884040","https://openalex.org/W2092462528","https://openalex.org/W2095934571","https://openalex.org/W2096057003","https://openalex.org/W2098577031","https://openalex.org/W2101988823","https://openalex.org/W2103867015","https://openalex.org/W2107614388","https://openalex.org/W2107943906","https://openalex.org/W2109511371","https://openalex.org/W2110817748","https://openalex.org/W2111403239","https://openalex.org/W2112651502","https://openalex.org/W2114860131","https://openalex.org/W2118726620","https://openalex.org/W2119346494","https://openalex.org/W2119999819","https://openalex.org/W2120932387","https://openalex.org/W2121070277","https://openalex.org/W2122683221","https://openalex.org/W2124036399","https://openalex.org/W2124156743","https://openalex.org/W2125673723","https://openalex.org/W2126595251","https://openalex.org/W2130728712","https://openalex.org/W2130972387","https://openalex.org/W2131660936","https://openalex.org/W2132380666","https://openalex.org/W2133853290","https://openalex.org/W2137613124","https://openalex.org/W2139777089","https://openalex.org/W2140638448","https://openalex.org/W2140886363","https://openalex.org/W2142583027","https://openalex.org/W2145200068","https://openalex.org/W2146741358","https://openalex.org/W2149468013","https://openalex.org/W2151014102","https://openalex.org/W2151411596","https://openalex.org/W2153057184","https://openalex.org/W2157690852","https://openalex.org/W2157899948","https://openalex.org/W2158696238","https://openalex.org/W2158900415","https://openalex.org/W2159099751","https://openalex.org/W2159168998","https://openalex.org/W2159675211","https://openalex.org/W2164530284","https://openalex.org/W2169741450","https://openalex.org/W2171806736","https://openalex.org/W2171840876","https://openalex.org/W2171972386","https://openalex.org/W2172192445","https://openalex.org/W2316716290","https://openalex.org/W2327887515","https://openalex.org/W2331081187","https://openalex.org/W2341209396","https://openalex.org/W2793216206","https://openalex.org/W4294184109"],"related_works":["https://openalex.org/W2056461221","https://openalex.org/W1964865859","https://openalex.org/W2101988823","https://openalex.org/W2043972688","https://openalex.org/W1972910961","https://openalex.org/W3217332990","https://openalex.org/W2005939114","https://openalex.org/W1996910195","https://openalex.org/W2097038959","https://openalex.org/W2315074483"],"abstract_inverted_index":{"Ataxia":[0],"telangiectasia-mutated":[1],"(ATM)":[2],"is":[3,41,75,159,239,247,270,278],"a":[4,186,201,209,285],"serine/threonine":[5],"protein":[6,138,292],"kinase":[7,47,73,83,96,156,243,274],"that":[8,93,120,134,151,169,232,263],"has":[9,91],"critical":[10],"functions":[11],"in":[12,35,44,102,125,220,258,294],"the":[13,46,53,66,79,121,145,163,191,228,233,242,264,273],"cellular":[14,67,122],"responses":[15,68],"to":[16,51,64,69,115,133,144,161,213,222,296],"DNA":[17,25,224,297],"damage,":[18],"including":[19],"cell":[20,165],"cycle":[21,166],"checkpoint":[22],"activation":[23],"and":[24,107,168],"repair.":[26],"Since":[27],"ataxia":[28],"telangiectasia":[29],"individuals,":[30],"who":[31],"have":[32],"homozygous":[33],"mutations":[34],"ATM,":[36],"are":[37],"exquisitely":[38],"radiosensitive":[39],"there":[40],"considerable":[42],"interest":[43],"inhibiting":[45],"activity":[48,74,157,244,275],"of":[49,55,109,154,173,190,194,227,235,245,266,276],"ATM":[50,72,82,95,130,137,155,174,196,215,246,277,289],"increase":[52],"efficacy":[54],"targeted":[56],"radiotherapy.":[57],"In":[58,147],"this":[59,182],"dissertation":[60],"work,":[61],"I":[62,113,149,199,261],"sought":[63],"understand":[65],"radiation":[70,251],"when":[71,136,241,272],"transiently":[76],"inhibited":[77,248,279],"using":[78,141],"small":[80],"molecule":[81],"inhibitor":[84],"KU55933.":[85],"During":[86],"my":[87],"PhD,":[88],"our":[89],"laboratory":[90],"shown":[92],"transient":[94,171],"inhibition":[97,172],"one":[98],"hour":[99],"post-irradiation":[100,158],"results":[101,283],"radiosensitization,":[103],"increased":[104],"chromosome":[105],"aberrations":[106],"abrogation":[108],"sister":[110],"chromatid":[111],"exchange.":[112],"contributed":[114],"these":[116],"findings":[117],"by":[118],"showing":[119],"radiosensitization":[123],"seen":[124,135],"H460":[126],"cells":[127],"with":[128,175,208],"kinase-inhibited":[129,195],"was":[131,139],"identical":[132],"disrupted":[140],"siRNA":[142],"prior":[143],"insult.":[146],"addition,":[148],"demonstrated":[150],"15":[152],"minutes":[153],"sufficient":[160],"trigger":[162],"G2/M":[164],"checkpoint,":[167],"subsequent":[170],"KU55933":[176],"does":[177],"not":[178],"affect":[179],"recovery":[180,255],"from":[181],"checkpoint.":[183],"To":[184],"gain":[185],"more":[187],"global":[188],"view":[189],"functional":[192],"consequences":[193],"following":[197,249,280],"irradiation,":[198],"utilized":[200],"SILAC-based":[202],"tandem":[203],"mass":[204],"spectrometry":[205],"approach,":[206],"combined":[207],"subcellular":[210],"fractionation":[211],"protocol,":[212],"determine":[214],"kinase-dependent":[216,290],"spatial":[217,291],"proteome":[218,230],"dynamics":[219,293],"response":[221,295],"radiation-induced":[223],"damage.":[225,298],"Analysis":[226],"chromatin-associated":[229],"revealed":[231],"retention":[234],"53BP1":[236],"at":[237],"chromatin":[238],"decreased":[240,271],"ionizing":[250],"(IR).":[252],"Using":[253],"fluorescence":[254],"after":[256],"photobleaching":[257],"live":[259],"cells,":[260],"determined":[262],"stability":[265],"IR-induced":[267],"GFP-53BP1":[268],"foci":[269],"IR.":[281],"These":[282],"provide":[284],"roadmap":[286],"for":[287],"understanding":[288]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
