{"id":"https://openalex.org/W1031497632","doi":null,"title":"Efficacy of ASP2151, a Novel Herpes Virus Helicase-Primase Inhibitor, in the Mouse Model of Herpes Simplex Keratitis","display_name":"Efficacy of ASP2151, a Novel Herpes Virus Helicase-Primase Inhibitor, in the Mouse Model of Herpes Simplex Keratitis","publication_year":2011,"publication_date":"2011-04-22","ids":{"openalex":"https://openalex.org/W1031497632","mag":"1031497632"},"language":"en","primary_location":{"id":"mag:1031497632","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2353127","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shinichi Sasaki","orcid":"https://orcid.org/0000-0002-2257-7658","observed_orcids":["https://orcid.org/0000-0002-2257-7658"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Sasaki","raw_affiliation_strings":["Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan"],"raw_orcid":"https://orcid.org/0000-0002-2257-7658","affiliations":[{"raw_affiliation_string":"Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013012506","display_name":"Tomoko Haruki","orcid":"https://orcid.org/0000-0002-1081-0870","observed_orcids":["https://orcid.org/0000-0002-1081-0870"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Haruki","raw_affiliation_strings":["Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan"],"raw_orcid":"https://orcid.org/0000-0002-1081-0870","affiliations":[{"raw_affiliation_string":"Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074043236","display_name":"Yukimi Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukimi Yamamoto","raw_affiliation_strings":["Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070301949","display_name":"Michiko Kandori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiko Kandori","raw_affiliation_strings":["Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074846491","display_name":"Keiko Yakura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Yakura","raw_affiliation_strings":["Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037451883","display_name":"Dai Miyazaki","orcid":"https://orcid.org/0000-0002-1647-4708","observed_orcids":["https://orcid.org/0000-0002-1647-4708"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Dai Miyazaki","raw_affiliation_strings":["Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan"],"raw_orcid":"https://orcid.org/0000-0002-1647-4708","affiliations":[{"raw_affiliation_string":"Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Suzuki","orcid":"https://orcid.org/0000-0003-4682-5086","observed_orcids":["https://orcid.org/0000-0003-4682-5086"]},"institutions":[{"id":"https://openalex.org/I142395110","display_name":"Astellas Pharma (Japan)","ror":"https://ror.org/01cjash87","country_code":"JP","type":"company","lineage":["https://openalex.org/I142395110"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Suzuki","raw_affiliation_strings":["Drug Discovery Research, Astellas Pharma, Inc., Tsukuba, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4682-5086","affiliations":[{"raw_affiliation_string":"Drug Discovery Research, Astellas Pharma, Inc., Tsukuba, Japan","institution_ids":["https://openalex.org/I142395110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031522859","display_name":"Yoshitsugu Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitsugu Inoue","raw_affiliation_strings":["Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Ophthalmology and Visual Science Faculty of Medicine Tottori University Yonago Japan","institution_ids":["https://openalex.org/I4588055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14887307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":"14","first_page":"2062","last_page":"2062"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.5893999934196472,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.5893999934196472,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.40799999237060547,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.7820000052452087},{"id":"https://openalex.org/keywords/helicase-primase-inhibitors","display_name":"helicase-primase inhibitor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/herpes-simplex-keratitis","display_name":"herpes simplex keratitis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antiviral-efficacy","display_name":"antiviral efficacy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6970000267028809},{"id":"https://openalex.org/keywords/ocular-herpes","display_name":"ocular herpes","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C194830204","wikidata":"https://www.wikidata.org/wiki/Q106940703","display_name":"Primase","level":5,"score":0.7946577072143555},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7186406850814819},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.6854642033576965},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.6021344661712646},{"id":"https://openalex.org/C2992174592","wikidata":"https://www.wikidata.org/wiki/Q5743653","display_name":"Herpes virus","level":3,"score":0.5996987819671631},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.5563546419143677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33462488651275635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32639914751052856},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2707675099372864},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.12647667527198792},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0815088152885437},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.05966314673423767},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1031497632","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2353127","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2126365791","https://openalex.org/W2000281649","https://openalex.org/W758321523","https://openalex.org/W640059092","https://openalex.org/W2023754862","https://openalex.org/W2016985047","https://openalex.org/W2131218250","https://openalex.org/W2993675519","https://openalex.org/W2031155789","https://openalex.org/W2884033548"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
