{"id":"https://openalex.org/W1030535918","doi":"https://doi.org/10.1201/9781420073522.ch22","title":"Sirtuin and Resveratrol","display_name":"Sirtuin and Resveratrol","publication_year":2009,"publication_date":"2009-10-06","ids":{"openalex":"https://openalex.org/W1030535918","doi":"https://doi.org/10.1201/9781420073522.ch22","mag":"1030535918"},"language":"en","primary_location":{"id":"doi:10.1201/9781420073522.ch22","doi":"https://doi.org/10.1201/9781420073522.ch22","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781420073522.ch22","pdf_url":null,"source":{"id":"https://openalex.org/S4210184271","display_name":"Oxidative stress and disease","issn_l":"2155-0255","issn":["2155-0255","2380-9590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Stress and Disease","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2146635993","display_name":"Micronutrients and Brain Health"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10261/36726","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074978554","display_name":"Merc\u00e8 Pall\u00e0s","orcid":"https://orcid.org/0000-0003-3095-4254","observed_orcids":["https://orcid.org/0000-0003-3095-4254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pall\u00e0s","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010410200","display_name":"Coral Sanfeliu","orcid":"https://orcid.org/0000-0002-9004-1206","observed_orcids":["https://orcid.org/0000-0002-9004-1206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Coral Sanfeliu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005549219","display_name":"Carme Pelegr\u00ed","orcid":"https://orcid.org/0000-0002-7734-1546","observed_orcids":["https://orcid.org/0000-0002-7734-1546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carme Pelegr\u00ed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005517954","display_name":"Rosa M. Crist\u00f2fol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosa Crist\u00f2fol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073770071","display_name":"Antoni Camins","orcid":"https://orcid.org/0000-0002-1229-5956","observed_orcids":["https://orcid.org/0000-0002-1229-5956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antoni Camins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097931422","display_name":"Merc\u00e8","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merc\u00e8","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006814614","display_name":"Jordi Vilaplana","orcid":"https://orcid.org/0000-0003-2113-238X","observed_orcids":["https://orcid.org/0000-0003-2113-238X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordi Vilaplana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirtuins","display_name":"sirtuins","score":0.9860000014305115},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.925000011920929},{"id":"https://openalex.org/keywords/protein-acetylation","display_name":"protein acetylation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/histone-acetyltransferase","display_name":"histone acetyltransferase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/sir2p","display_name":"Sir2p","score":0.7540000081062317},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/lysine-deacetylation","display_name":"lysine deacetylation","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.8579748868942261},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.6606662273406982},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32948970794677734},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20398175716400146},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19429299235343933},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04989731311798096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1201/9781420073522.ch22","doi":"https://doi.org/10.1201/9781420073522.ch22","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781420073522.ch22","pdf_url":null,"source":{"id":"https://openalex.org/S4210184271","display_name":"Oxidative stress and disease","issn_l":"2155-0255","issn":["2155-0255","2380-9590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Stress and Disease","raw_type":"book-chapter"},{"id":"pmh:oai:digital.csic.es:10261/36726","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/36726","pdf_url":"http://hdl.handle.net/10261/36726","source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Cap\u00edtulo de libro"}],"best_oa_location":{"id":"pmh:oai:digital.csic.es:10261/36726","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/36726","pdf_url":"http://hdl.handle.net/10261/36726","source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Cap\u00edtulo de libro"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1030535918.pdf","grobid_xml":"https://content.openalex.org/works/W1030535918.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W52970530","https://openalex.org/W179756065","https://openalex.org/W1483432124","https://openalex.org/W1553938284","https://openalex.org/W1579832894","https://openalex.org/W1857137828","https://openalex.org/W1963585747","https://openalex.org/W1974431794","https://openalex.org/W1974469085","https://openalex.org/W1979501382","https://openalex.org/W1980959448","https://openalex.org/W1981968492","https://openalex.org/W1984580144","https://openalex.org/W1985308585","https://openalex.org/W1987738803","https://openalex.org/W1988531009","https://openalex.org/W1989522802","https://openalex.org/W1991124307","https://openalex.org/W1992902970","https://openalex.org/W1997145913","https://openalex.org/W1997580846","https://openalex.org/W2000282255","https://openalex.org/W2002468355","https://openalex.org/W2003894821","https://openalex.org/W2005789183","https://openalex.org/W2006510420","https://openalex.org/W2009244828","https://openalex.org/W2012539775","https://openalex.org/W2014941190","https://openalex.org/W2016436495","https://openalex.org/W2018188862","https://openalex.org/W2021645116","https://openalex.org/W2023448021","https://openalex.org/W2027943537","https://openalex.org/W2029254536","https://openalex.org/W2039451247","https://openalex.org/W2040462263","https://openalex.org/W2044578262","https://openalex.org/W2046117954","https://openalex.org/W2058768220","https://openalex.org/W2060067383","https://openalex.org/W2065446982","https://openalex.org/W2066795714","https://openalex.org/W2074569125","https://openalex.org/W2074916731","https://openalex.org/W2078023359","https://openalex.org/W2082792223","https://openalex.org/W2087797348","https://openalex.org/W2088355928","https://openalex.org/W2088381487","https://openalex.org/W2089010260","https://openalex.org/W2089714642","https://openalex.org/W2089977716","https://openalex.org/W2090381051","https://openalex.org/W2096410114","https://openalex.org/W2096796564","https://openalex.org/W2097948853","https://openalex.org/W2102646072","https://openalex.org/W2106920456","https://openalex.org/W2111092938","https://openalex.org/W2114622817","https://openalex.org/W2119898601","https://openalex.org/W2121764638","https://openalex.org/W2122073743","https://openalex.org/W2122598808","https://openalex.org/W2123700755","https://openalex.org/W2123927456","https://openalex.org/W2125121177","https://openalex.org/W2131541317","https://openalex.org/W2132682806","https://openalex.org/W2135387645","https://openalex.org/W2136830554","https://openalex.org/W2140925956","https://openalex.org/W2150494811","https://openalex.org/W2153109972","https://openalex.org/W2154587590","https://openalex.org/W2161133182","https://openalex.org/W2161678021","https://openalex.org/W2165977025","https://openalex.org/W2170498202","https://openalex.org/W7098997929","https://openalex.org/W7100891922"],"related_works":["https://openalex.org/W4240873071","https://openalex.org/W2493543206","https://openalex.org/W2492297194","https://openalex.org/W4243594320","https://openalex.org/W2480210015","https://openalex.org/W2492203076","https://openalex.org/W4243110408","https://openalex.org/W2481536138","https://openalex.org/W2491171004","https://openalex.org/W2498224135"],"abstract_inverted_index":{"Protein":[0],"acetylation":[1,24,52],"is":[2,61,75],"involved":[3],"in":[4,40],"the":[5,23,104,115],"regulation":[6],"of":[7,25,33,42,47,51,84],"several":[8],"cellular":[9,64],"functions":[10],"such":[11],"as":[12,70,124],"protein-protein":[13],"interactions,":[14],"protein":[15],"stability,":[16],"and":[17,53,97,107,120,127],"DNA":[18],"recognition":[19],"by":[20,56,133],"proteins.For":[21],"instance,":[22],"histone":[26,71,80],"proteins":[27,57,66],"alters":[28],"gene":[29,48],"transcription":[30],"[1].Thus,":[31],"removal":[32],"acetyl":[34],"groups":[35],"from":[36],"lysine":[37],"residues":[38],"results":[39],"compaction":[41],"chromatin":[43],"and,":[44],"hence,":[45],"repression":[46],"transcription.The":[49],"process":[50],"deacetylation":[54],"regulated":[55],"with":[58],"acetyltransferase":[59],"activity":[60],"important":[62],"for":[63,79],"processes.These":[65],"are":[67,101,112,121,131],"usually":[68],"known":[69],"acetyltransferases":[72],"[2].Nowadays,":[73],"there":[74],"a":[76],"growing":[77],"interest":[78],"deacetylases":[81],"(HDACs)":[82],"because":[83],"their":[85],"potential":[86],"clinical":[87],"applications":[88],"[3].HDACs":[89],"have":[90],"been":[91],"divided":[92],"into":[93],"four":[94],"groups.Class":[95],"I":[96,126],"class":[98,128],"II":[99,129],"HDACs":[100,111,130],"similar":[102,113],"to":[103,114,123],"yeast":[105,116],"Rpd3p":[106],"Hda1p":[108],"proteins.Class":[109],"III":[110],"transcriptional":[117],"repressor":[118],"Sir2p":[119],"referred":[122],"sirtuins.Class":[125],"characterized":[132],"contents":[134]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
