{"id":"https://openalex.org/W102979316","doi":"https://doi.org/10.1182/blood.v84.2.608.608","title":"Interleukin-4 receptor regulation in human monocytic cells","display_name":"Interleukin-4 receptor regulation in human monocytic cells","publication_year":1994,"publication_date":"1994-07-15","ids":{"openalex":"https://openalex.org/W102979316","doi":"https://doi.org/10.1182/blood.v84.2.608.608","mag":"102979316","pmid":"https://pubmed.ncbi.nlm.nih.gov/8025287"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v84.2.608.608","doi":"https://doi.org/10.1182/blood.v84.2.608.608","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v84.2.608.608","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103558391","display_name":"Harry de Wit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H de Wit","raw_affiliation_strings":["Department of Internal Medicine, University of Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111401988","display_name":"DW Hendriks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"DW Hendriks","raw_affiliation_strings":["Department of Internal Medicine, University of Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042903049","display_name":"MR Halie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"MR Halie","raw_affiliation_strings":["Department of Internal Medicine, University of Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050532707","display_name":"Edo Vellenga","orcid":"https://orcid.org/0000-0002-7741-8697","observed_orcids":["https://orcid.org/0000-0002-7741-8697"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E Vellenga","raw_affiliation_strings":["Department of Internal Medicine, University of Groningen, The Netherlands","Guided Treatment in Optimal Selected Cancer Patients (GUTS)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]},{"raw_affiliation_string":"Guided Treatment in Optimal Selected Cancer Patients (GUTS)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I169381384"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.7352,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.86284995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"84","issue":"2","first_page":"608","last_page":"615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-4-receptor","display_name":"interleukin-4 receptor","score":1.0},{"id":"https://openalex.org/keywords/monocytic-cells","display_name":"monocytic cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/receptor-regulation","display_name":"receptor regulation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.777999997138977},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.925000011920929},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.7850000262260437},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.9160000085830688},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6759999990463257},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cd23","display_name":"CD23","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.996999979019165},{"id":"https://openalex.org/keywords/mrna-half-life","display_name":"mRNA half-life","score":0.6480000019073486},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/common-gamma-chain","display_name":"common gamma chain","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cell-type-differences","display_name":"cell type differences","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6368848085403442},{"id":"https://openalex.org/C34814297","wikidata":"https://www.wikidata.org/wiki/Q4845302","display_name":"CD23","level":4,"score":0.5923716425895691},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5726660490036011},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.564042866230011},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5456810593605042},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.5309920310974121},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5302094221115112},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48649924993515015},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19206887483596802},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14157810807228088},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.12382715940475464},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.08848491311073303}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011975","descriptor_name":"Receptors, Mitogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011975","descriptor_name":"Receptors, Mitogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017455","descriptor_name":"Receptors, IgE","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019948","descriptor_name":"Receptors, Interleukin-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1182/blood.v84.2.608.608","doi":"https://doi.org/10.1182/blood.v84.2.608.608","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v84.2.608.608","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v84.2.608.bloodjournal842608","doi":"https://doi.org/10.1182/blood.v84.2.608.bloodjournal842608","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v84.2.608.bloodjournal842608","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:8025287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8025287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/0cc3e43c-07b9-4eb1-9328-e0dfe733c5e5","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11370/0cc3e43c-07b9-4eb1-9328-e0dfe733c5e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DEWIT, H, HENDRIKS, DW, HALIE, MR & VELLENGA, E 1994, 'INTERLEUKIN-4 RECEPTOR REGULATION IN HUMAN MONOCYTIC CELLS', Blood, vol. 84, no. 2, pp. 608-615.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/0cc3e43c-07b9-4eb1-9328-e0dfe733c5e5","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/0cc3e43c-07b9-4eb1-9328-e0dfe733c5e5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood, 84(2), 608 - 615. AMER SOC HEMATOLOGY","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W145109298","https://openalex.org/W151793644","https://openalex.org/W243049598","https://openalex.org/W1502572167","https://openalex.org/W1520796352","https://openalex.org/W1521414677","https://openalex.org/W1526431037","https://openalex.org/W1559597818","https://openalex.org/W1566008126","https://openalex.org/W1594985634","https://openalex.org/W1598422803","https://openalex.org/W1606617874","https://openalex.org/W1629406534","https://openalex.org/W1962137092","https://openalex.org/W1965858747","https://openalex.org/W1970221942","https://openalex.org/W1992796891","https://openalex.org/W1993015867","https://openalex.org/W2005388055","https://openalex.org/W2013994536","https://openalex.org/W2014669590","https://openalex.org/W2038961948","https://openalex.org/W2068626888","https://openalex.org/W2071143253","https://openalex.org/W2084228983","https://openalex.org/W2093107928","https://openalex.org/W2102464938","https://openalex.org/W2106800523","https://openalex.org/W2110260516","https://openalex.org/W2114279495","https://openalex.org/W2134521609","https://openalex.org/W2134818464","https://openalex.org/W2135757997","https://openalex.org/W2144634347","https://openalex.org/W2153011776","https://openalex.org/W2404397258","https://openalex.org/W2407740578","https://openalex.org/W2408973025","https://openalex.org/W2415613000"],"related_works":["https://openalex.org/W1502572167","https://openalex.org/W2414744586","https://openalex.org/W2134521609","https://openalex.org/W2093851140","https://openalex.org/W83913475","https://openalex.org/W145109298","https://openalex.org/W1962137092","https://openalex.org/W2405469828","https://openalex.org/W2004517076","https://openalex.org/W2408626480"],"abstract_inverted_index":{"The":[0,133,175],"regulation":[1,163],"of":[2,21,29,41,74,85,104,117,183,198],"the":[3,71,77,83,102,130,149,181,184,196,199,223],"interleukin-4":[4],"receptor":[5,144,187],"(IL-4R)":[6],"was":[7,88],"studied":[8],"at":[9,57,112],"mRNA":[10,58,87],"and":[11,26,48,59,63,82,152,172,195],"protein":[12,30,42,60],"level":[13],"in":[14,52,70,97,159,164,192,202],"monocytic":[15,203],"cells":[16,194],"on":[17,129,222],"stimulation":[18,123],"with":[19,34,46,94,120,124,161],"activators":[20],"different":[22],"intracellular":[23],"signaling":[24],"pathways":[25,33,45,119],"IL-4.":[27],"Activation":[28],"kinase":[31,43],"C-dependent":[32],"phorbol":[35],"myristate":[36],"acetate":[37],"(PMA)":[38],"or":[39,122],"activation":[40,116],"A-dependent":[44],"DBcAMP":[47,75],"prostaglandin":[49],"E2":[50],"resulted":[51],"an":[53],"augmented":[54],"IL-4R":[55,86,131,162],"expression":[56],"level.":[61,114],"Transcriptional":[62],"posttranscriptional":[64],"mechanisms":[65],"seemed":[66],"to":[67,90,110,135,141],"be":[68,108,139,178],"involved":[69],"promotive":[72],"effect":[73,103,128],"because":[76,145],"transcription":[78],"rate":[79],"increased":[80],"1.8-fold,":[81],"half-life":[84],"prolonged":[89],"150":[91],"minutes":[92,96],"compared":[93],"120":[95],"unstimulated":[98],"cells.":[99],"In":[100],"contrast,":[101],"PMA":[105],"could":[106,137],"only":[107],"ascribed":[109,140],"changes":[111],"transcriptional":[113],"However,":[115],"Ca(2+)-dependent":[118,173],"A23187":[121],"IL-4":[125,136,146],"had":[126],"no":[127],"expression.":[132,155],"unresponsiveness":[134],"not":[138],"a":[142],"nonfunctional":[143],"did":[147],"modulate":[148],"CD14,":[150],"CD23,":[151],"HLA-DR":[153],"antigen":[154],"These":[156,213],"results":[157],"are":[158,218],"contrast":[160],"T":[165,193],"cells,":[166,204],"which":[167],"is":[168],"affected":[169],"by":[170,180,209],"IL-4-":[171],"pathways.":[174],"discrepancy":[176],"might":[177],"caused":[179],"presence":[182],"common":[185],"IL-2":[186],"gamma":[188,200],"chain":[189,211],"(gamma":[190],"c)":[191],"absence":[197],"c":[201],"as":[205],"has":[206],"been":[207],"shown":[208],"polymerase":[210],"reaction.":[212],"data":[214],"indicate":[215],"that":[216],"IL-4Rs":[217],"differentially":[219],"regulated,":[220],"depending":[221],"cell":[224],"type":[225],"studied.":[226]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}