{"id":"https://openalex.org/W102649189","doi":null,"title":"Type II collagen peptides for measuring cartilage degradation.","display_name":"Type II collagen peptides for measuring cartilage degradation.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W102649189","mag":"102649189","pmid":"https://pubmed.ncbi.nlm.nih.gov/15299285"},"language":"en","primary_location":{"id":"pmid:15299285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15299285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biorheology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012454701","display_name":"Yves Edgard Henrotin","orcid":"https://orcid.org/0000-0003-1073-449X","observed_orcids":["https://orcid.org/0000-0003-1073-449X"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Y Henrotin","raw_affiliation_strings":["Bone and Cartilage Research Unit, Institute of Pathology, CHU Sart-Tilman, 4000 Li\u00e8ge, Belgium. yhenrotin@ulg.ac.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Cartilage Research Unit, Institute of Pathology, CHU Sart-Tilman, 4000 Li\u00e8ge, Belgium. yhenrotin@ulg.ac.be","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019232047","display_name":"Michelle A. Deberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M Deberg","raw_affiliation_strings":["Universit\u00e9 de Li\u00e8ge - ULi\u00e8ge >  > Unit\u00e9 de recherche sur l'os et le cartillage (U.R.O.C.) >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Li\u00e8ge - ULi\u00e8ge >  > Unit\u00e9 de recherche sur l'os et le cartillage (U.R.O.C.) >","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111630521","display_name":"J.-E. Dubuc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J-E Dubuc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069972661","display_name":"E Quettier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Quettier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107484196","display_name":"Stephan Christgau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Christgau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108636106","display_name":"J.-Y. Reginster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J-Y Reginster","raw_affiliation_strings":["Universit\u00e9 de Li\u00e8ge - ULi\u00e8ge > D\u00e9partement des sciences de la sant\u00e9 publique > Epid\u00e9miologie et sant\u00e9 publique > >  >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Li\u00e8ge - ULi\u00e8ge > D\u00e9partement des sciences de la sant\u00e9 publique > Epid\u00e9miologie et sant\u00e9 publique > >  >","institution_ids":["https://openalex.org/I157674565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3527,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.86930693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"41","issue":"3-4","first_page":"543","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.8859999775886536},{"id":"https://openalex.org/keywords/collagen-peptides","display_name":"collagen peptides","score":0.5649999976158142},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.7490000128746033},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5479999780654907},{"id":"https://openalex.org/keywords/joint-space-narrowing","display_name":"joint space narrowing","score":0.8479999899864197},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5120000243186951},{"id":"https://openalex.org/keywords/serum-levels","display_name":"serum concentration","score":0.4350000023841858},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.777999997138977},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7395551204681396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6531744003295898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6009378433227539},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5443862676620483},{"id":"https://openalex.org/C2781013607","wikidata":"https://www.wikidata.org/wiki/Q14877666","display_name":"Type II collagen","level":3,"score":0.4897051155567169},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4225800633430481},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40300413966178894},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4013154208660126},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2648245096206665},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.13631302118301392},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07851061224937439},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:15299285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15299285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biorheology","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:281535","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/281535","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biorheology, Vol. 41, no.3-4, p. 543-7 (2004)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/111206","doi":null,"is_oa":false,"landing_page_url":"https://orbi.uliege.be/handle/2268/111206","pdf_url":null,"source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biorheology, 41 (3-4), 543-547 (2004)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:102649189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15299285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W55232853","https://openalex.org/W569919225","https://openalex.org/W1987469947","https://openalex.org/W2003867975","https://openalex.org/W2007202300","https://openalex.org/W2081013324","https://openalex.org/W2081563776","https://openalex.org/W2087193732","https://openalex.org/W2125310185","https://openalex.org/W2153862724","https://openalex.org/W2167267852","https://openalex.org/W2239405448","https://openalex.org/W2256050350"],"related_works":["https://openalex.org/W1986671183","https://openalex.org/W2138894167","https://openalex.org/W2117049367","https://openalex.org/W2268378782","https://openalex.org/W2229564543","https://openalex.org/W2051180888","https://openalex.org/W3093635080","https://openalex.org/W2165844082","https://openalex.org/W566324342","https://openalex.org/W4253883954"],"abstract_inverted_index":{"This":[0],"paper":[1],"describes":[2],"two":[3],"new":[4],"immunoassays":[5],"for":[6],"a":[7,146],"peptide":[8],"of":[9,13,66,111,115,127,149],"the":[10,112],"triple":[11],"helix":[12],"type":[14],"II":[15],"collagen":[16],"(Coll":[17,23],"2-1)":[18],"and":[19,32,38,49],"its":[20],"nitrated":[21],"form":[22],"2-1":[24,37,40,69,87,117,120,143],"NO(2)).":[25],"In":[26,80,135],"healthy":[27,97],"subjects":[28],"aged":[29],"between":[30],"20":[31],"65":[33],"years":[34,65],"old,":[35],"Coll":[36,39,68,86,116,119,142],"NO(2)":[41,70,121],"levels":[42,54,71,114],"in":[43,46,72,78,88,132],"serum":[44,89],"were":[45,74],"means":[47],"125.13+/-3.71":[48],"0.16+/-0.08":[50],"nmol/l,":[51],"respectively.":[52],"These":[53],"did":[55],"not":[56],"significantly":[57,75],"vary":[58],"with":[59,82],"age.":[60],"However,":[61],"up":[62],"to":[63,92,96],"45":[64],"age,":[67],"women":[73],"higher":[76],"than":[77],"men.":[79],"patients":[81],"knee":[83,150],"osteoarthritis":[84],"(OA),":[85],"was":[90,125],"found":[91],"be":[93,145],"elevated":[94],"compared":[95],"controls":[98],"(267.45+/-26.42":[99],"nmol/l":[100],"vs":[101],"126.78+/-6.61":[102],"nmol/l).":[103],"Further,":[104],"we":[105],"have":[106],"demonstrated":[107],"that":[108,141],"an":[109],"increase":[110],"urinary":[113],"or":[118],"over":[122],"1":[123],"year":[124],"predictive":[126,147],"joint":[128],"space":[129],"narrowing":[130],"progression":[131],"OA":[133,151],"patients.":[134],"conclusion,":[136],"these":[137],"preliminary":[138],"results":[139],"indicate":[140],"could":[144],"marker":[148],"progression.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}