{"id":"https://openalex.org/W102524327","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.533.1","title":"Measurement of vitamin K homologues in biological fluids and tissues by APCI LC/MS","display_name":"Measurement of vitamin K homologues in biological fluids and tissues by APCI LC/MS","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W102524327","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.533.1","mag":"102524327"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.533.1","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.533.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.533.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075389007","display_name":"Scott William Leonard","orcid":"https://orcid.org/0000-0001-9967-7078","observed_orcids":["https://orcid.org/0000-0001-9967-7078"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott William Leonard","raw_affiliation_strings":["Linus Pauling Institute Oregon State University Corvallis OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Linus Pauling Institute Oregon State University Corvallis OR","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112430940","display_name":"Tyler Barker","orcid":"https://orcid.org/0000-0001-7425-9582","observed_orcids":["https://orcid.org/0000-0001-7425-9582"]},"institutions":[{"id":"https://openalex.org/I2801974725","display_name":"Orthopedic Specialty Hospital","ror":"https://ror.org/04pb6gq71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I2801974725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Barker","raw_affiliation_strings":["Sport Science Department The Orthopedic Specialty Hospital Murray UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sport Science Department The Orthopedic Specialty Hospital Murray UT","institution_ids":["https://openalex.org/I2801974725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085173566","display_name":"Debbie J. Mustacich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debbie J Mustacich","raw_affiliation_strings":["Linus Pauling Institute Oregon State University Corvallis OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Linus Pauling Institute Oregon State University Corvallis OR","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069647536","display_name":"Maret G. Traber","orcid":"https://orcid.org/0000-0002-2892-4024","observed_orcids":["https://orcid.org/0000-0002-2892-4024"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maret G Traber","raw_affiliation_strings":["Linus Pauling Institute Oregon State University Corvallis OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Linus Pauling Institute Oregon State University Corvallis OR","institution_ids":["https://openalex.org/I131249849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01861147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-k","display_name":"vitamin K","score":0.8650000095367432},{"id":"https://openalex.org/keywords/vitamin-k1","display_name":"vitamin K1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/vitamin-k2","display_name":"vitamin K2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/menadione","display_name":"menadione","score":0.9150000214576721},{"id":"https://openalex.org/keywords/menaquinone-4","display_name":"menaquinone-4","score":0.7670000195503235},{"id":"https://openalex.org/keywords/menaquinone-7","display_name":"menaquinone-7","score":0.9900000095367432},{"id":"https://openalex.org/keywords/body-fluids","display_name":"biological fluids","score":0.6850000023841858},{"id":"https://openalex.org/keywords/tissues","display_name":"tissues","score":0.6570000052452087},{"id":"https://openalex.org/keywords/plasma","display_name":"plasma","score":0.7300000190734863},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.8370000123977661},{"id":"https://openalex.org/keywords/urine","display_name":"urine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/vitamin-k-deficiency","display_name":"vitamin K deficiency","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7489895224571228},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6859186291694641},{"id":"https://openalex.org/C2781095387","wikidata":"https://www.wikidata.org/wiki/Q192471","display_name":"Menadione","level":3,"score":0.659149169921875},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.5711579918861389},{"id":"https://openalex.org/C148065180","wikidata":"https://www.wikidata.org/wiki/Q900711","display_name":"Atmospheric-pressure chemical ionization","level":5,"score":0.529615044593811},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5222473740577698},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.48880597949028015},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.4851897358894348},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.47390830516815186},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.4351332187652588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1716788411140442},{"id":"https://openalex.org/C51884965","wikidata":"https://www.wikidata.org/wiki/Q471254","display_name":"Chemical ionization","level":4,"score":0.08769538998603821},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08614650368690491},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.533.1","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.533.1","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.533.1","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4417426991","https://openalex.org/W2035207536","https://openalex.org/W4409037580","https://openalex.org/W4414138996","https://openalex.org/W1977948462","https://openalex.org/W3004855296","https://openalex.org/W2046211909","https://openalex.org/W2018561584","https://openalex.org/W4223982819","https://openalex.org/W2973494578"],"abstract_inverted_index":{"Vitamin":[0],"K":[1,56,59,65,90,93,113,139,144,152,175,194,202,209,233],"(K)":[2],"is":[3,221],"a":[4,10,19,44,75,83,116,155,164,193],"family":[5],"of":[6,100,118,132,167,169,173,208,229],"molecules":[7],"that":[8],"contains":[9],"2\u2010methyl\u20101,4\u2010napthoquinone":[11],"nucleus,":[12],"including":[13],"phylloquinone":[14],"(K":[15,29,37],"1":[16,57,91,140,159,176,203],")":[17,34],"with":[18,24,163,217],"isoprenyl":[20,26],"side":[21,27],"chain,":[22],"menaquinones":[23],"unsaturated":[25],"chains":[28],"2":[30,60,94,142],";":[31,39],"MK\u2010":[32],"n":[33],"and":[35,46,64,70,134,143,223,249],"menadione":[36],"3":[38,66,114,145,195,210],"MK\u20100).":[40],"Here":[41],"we":[42],"describe":[43],"sensitive":[45,222],"specific":[47,224],"liquid":[48],"chromatography":[49],"mass":[50],"spectrometry":[51],"(LC/MS)":[52],"method":[53,98],"to":[54,82,160,226],"measure":[55,227],",":[58,115,146],"(MK\u20104":[61],"&":[62,92],"MK\u20107),":[63],"in":[67,179,213,235,242],"biological":[68,236],"fluids":[69],"tissues.":[71],"For":[72,89,112],"all":[73,228],"assays":[74],"Micromass":[76],"ZQ":[77],"2000":[78],"MS":[79],"detector":[80],"coupled":[81],"Waters":[84],"2695":[85],"HPLC":[86],"was":[87,110,128,177,184,199,204,240],"used.":[88,111,129],"analysis":[95],"an":[96,218],"isocratic":[97],"consisting":[99],"100%":[101],"methanol":[102,120],"delivered":[103,121],"at":[104,125],"1.0":[105],"mL/min":[106,127],"for":[107,138,150],"30":[108,123],"min":[109,124],"gradient":[117],"50\u201390%":[119],"over":[122],"0.2":[126,170],"Internal":[130],"standards":[131],"ubiquinone\u20104":[133],"\u20102":[135],"were":[136,211],"used":[137],"/K":[141],"respectively.":[147],"Calibration":[148],"curves":[149],"the":[151,214,230,245,247],"forms":[153],"generated":[154],"linear":[156],"response":[157],"from":[158,188],"50":[161],"nM,":[162],"lower":[165],"limit":[166],"detection":[168],"nM":[171],"(S/N":[172],"3/1).":[174],"detectable":[178,200],"human":[180],"plasma,":[181],"but":[182,201],"MK\u20104":[183,198],"not.":[185],"In":[186],"livers":[187],"male":[189],"Sprague\u2010Dawley":[190],"rats":[191],"consuming":[192],"\u2010containing":[196],"diet,":[197],"not;":[205],"large":[206],"amounts":[207],"present":[212],"urine.":[215],"LC/MS":[216],"APCI":[219],"source":[220],"enough":[225],"expected":[231],"vitamin":[232],"homologues":[234],"samples.":[237],"This":[238],"work":[239],"funded":[241],"part":[243],"by":[244],"USDA,":[246],"NIH,":[248],"USANA.":[250]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}